Advances in hydrogel for diagnosis and treatment for Parkinson’s disease
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 12, 2025
Currently,
few
symptomatic
and
palliative
care
options
are
available
for
patients
with
Parkinson's
disease
(PD).
Interdisciplinary
research
in
materials
engineering
regenerative
medicine
has
stimulated
the
development
of
innovative
therapeutic
strategy
PD.
Hydrogels,
which
versatile
accessible
to
modify,
have
garnered
considerable
interests.
Hydrogels
a
kind
three-dimensional
hydrophilic
network
structure
gels
that
widely
employed
biological
materials.
conspicuous
many
applications,
including
neuron
regeneration,
neuroprotection,
diagnosis.
This
review
focuses
on
advantageous
applications
hydrogel-based
biomaterials
diagnosing
treating
PD,
cell
culture,
modeling,
carriers
cells,
medications
proteins,
as
well
diagnostic
monitoring
biosensors.
Язык: Английский
Advancements in Stem Cell Therapeutics for Spinal Cord Injury: Theories and Applications
Pingping Mi,
Yanjie Zhong,
Yao Xu
и другие.
Journal of Biosciences and Medicines,
Год журнала:
2025,
Номер
13(01), С. 102 - 131
Опубликована: Янв. 1, 2025
Язык: Английский
Transformative Advances in Modeling Brain Aging and Longevity: Success, Challenges and Future Directions
Ageing Research Reviews,
Год журнала:
2025,
Номер
unknown, С. 102753 - 102753
Опубликована: Апрель 1, 2025
Язык: Английский
Nanomaterials in Regenerative Medicine: Advancing the Future of Tissue Engineering
Regenerative Engineering and Translational Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 6, 2025
Язык: Английский
In Situ Magnetoelectric Generation of miRNA Sponges and Wireless Electric Stimulus by Conductive Granular Scaffolds for Nerve Regeneration
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 29, 2025
Abstract
Electronic
signaling
and
microRNA
(miRNA)
regulation
play
pivotal
roles
in
determining
neuronal
cell
fate
promoting
brain
recovery.
Despite
this,
clinical
advancements
are
hindered
by
the
limited
availability
of
tools
for
spatiotemporal
electrical
non‐viral
gene
modulation
neurons
vivo.
In
this
study,
a
conductive
granular
scaffold
(cGRAS)
that
doubles
as
an
antenna
delivery
agent
targeted
miRNA
nerve
repair
traumatic
injury
(TBI)
is
developed.
The
inherent
features
scaffolds
reduce
inflammation
glial
scarring
TBI
mitigating
activated
microglia
stellate
cells.
Upon
irradiation
with
external
alternating
magnetic
field
(AMF),
“electromagnetic
messenger”
induces
stimulation
to
restore
function
promotes
temporal
electroporation.
This
process,
together
mechanotransduction
capability
cGRAS,
enhances
formation
sponges
both
vitro
vivo,
thereby
reducing
overexpression
miR6263,
which
significantly
upregulated
upon
injury.
whole
imaging
analysis,
suppression
inflammation,
angiogenesis
around
cavity,
infiltration
newborn
injured
area
observed
after
situ
magnetoelectric
wireless
electric
stimulus,
leading
improved
behavioral
Overall,
cGRAS
represents
potentially
innovative
versatile
tool
regeneration
engineering.
Язык: Английский
DNA Nano‐Biomaterials Based Futuristic Technologies for Tissue Engineering and Regenerative Therapeutics
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
The
ability
to
completely
repair
or
regenerate
injured
tissues
organs
and
restore
their
functionality
has
long
been
a
goal
of
humankind.
advancements
in
tissue
engineering
regenerative
medicine
have
made
this
conceivable.
With
the
precisely
manipulate
nanoscale
architectures
for
designing
biomaterials,
DNA
nanotechnology
emerged
as
groundbreaking
technique
medicine.
DNA-based
nanostructures
are
well-suited
directing
cellular
interactions,
delivering
therapeutic
drugs,
mimicking
extracellular
matrix
components
due
exceptional
biocompatibility,
programmability,
molecular
recognition
capabilities.
Recent
developments
demonstrated
that
nanodevices
can
be
used
administer
drugs
growth
factors
controlled
manner,
well
enhance
cell
adhesion,
proliferation,
differentiation.
Furthermore,
capacity
respond
biological
stimuli
enables
dynamic
adaptable
regeneration
techniques.
This
review
highlights
latest
advances
applications,
its
benefits
over
traditional
potential
future
pathways
clinical
translation.
Язык: Английский
Sympathetic chain reconstruction after failed sympathectomy for hyperhidrosis in regenerative medicine: a narrative review
Regenerative medicine reports .,
Год журнала:
2024,
Номер
1(2), С. 149 - 155
Опубликована: Дек. 1, 2024
Hyperhidrosis
is
a
pathologic
condition
characterized
by
abnormal
sweating
that
greater
than
normally
needed
for
proper
thermoregulation.
Surgical
therapy
remains
the
only
effective
treatment
definitive
cure
of
idiopathic
focal
hyperhidrosis,
although
some
controversies
still
exist
regarding
best
operation.
The
most
significant
side
effect
hyperhidrosis
surgery
compensatory
hyperhidrosis.
Although
severe
less
frequent
form,
it
results
in
detrimental
on
quality
life,
and
restoration
pre-surgical
advocated
affected
patients.
Sympathetic
chain
reconstruction
represents
surgical
option
managing
after
failed
sympathetic
surgery,
without
results.
In
this
review,
we
focus
experimental
clinical
data
use
compensated
sympathectomy
Regenerative
medicine,
particularly
tissue
engineering
stem
cell
technology,
offers
new
therapeutic
strategies
reconstruction.
These
may
improve
or
resolve
promoting
nerve
regeneration.
However,
there
are
number
problems
with
current
research,
including
inconsistency
outcomes,
lack
long-term
follow-up
data,
insufficient
in-depth
understanding
regenerative
medicine
techniques.
Nonetheless,
progress
has
been
made
studies.
For
example,
regeneration
demonstrated
animal
models,
different
methods
reconstruction,
autologous
grafts
conduits,
have
shown
studies
provide
preliminary
evidence
significance
conclusion,
development
hope
patients
primary
even
though
treatments
not
yet
achieved
desired
With
further
technological
technology
expected
to
be
means
treating
thus
significantly
improving
life
Язык: Английский