For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy
Soroush Karimi,
Roksana Bakhshali,
Soheil Bolandi
и другие.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101626 - 101626
Опубликована: Март 1, 2025
Cancer
treatment
is
challenged
by
the
tumor
microenvironment
(TME),
which
promotes
drug
resistance
and
cancer
cell
growth.
This
review
offers
a
comprehensive
innovative
perspective
on
how
nanomedicine
can
modify
TME
to
enhance
therapy.
Strategies
include
using
nanoparticles
improve
oxygenation,
adjust
acidity,
alter
extracellular
matrix,
making
treatments
more
effective.
Additionally,
immune
responses
activating
cells
reducing
suppression
within
tumors.
By
integrating
these
approaches
with
existing
therapies,
such
as
chemotherapy
radiotherapy,
show
promise
in
overcoming
traditional
barriers.
The
discusses
changes
effectiveness
of
itself,
creating
reciprocal
relationship
that
boosts
overall
efficacy.
We
also
highlight
novel
strategies
aimed
at
exploiting
TME,
leveraging
nanoparticle-based
for
targeted
therapy
through
precise
modulation.
Язык: Английский
Bioorthogonal Chemistry-Based Prodrug Strategies for Enhanced Biosafety in Tumor Treatments: Current Progress and Challenges
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(42), С. 10818 - 10834
Опубликована: Янв. 1, 2024
Prodrugs,
activated
at
the
tumor
site,
offer
targeted
treatment
but
may
still
cause
unintended
cytotoxicity.
This
review
explores
combination
of
bioorthogonal
reactions
with
prodrug
strategies
to
improve
safety
and
efficacy.
Язык: Английский
AQ4N Nanocomposites for their Hypoxia associated Tumor Combination Therapy
Biomaterials Science,
Год журнала:
2024,
Номер
12(23), С. 5883 - 5911
Опубликована: Янв. 1, 2024
Hypoxia
in
solid
tumors
increases
their
invasiveness
and
resistance
to
therapy,
presenting
a
formidable
obstacle
tumor
therapy.
The
hypoxia
prodrug
banoxantrone
(AQ4N)
undergoes
conversion
into
its
topoisomerase
II
inhibitor
form
AQ4
under
hypoxic
conditions,
which
inhibits
cells
while
leaving
normal
unharmed.
Numerous
studies
have
found
that
AQ4N
significantly
enhances
the
effect
minimizing
toxicity
tissues
when
combined
with
other
drugs
or
therapeutic
approaches.
Thus,
maximize
AQ4N's
effectiveness,
co-delivery
of
agents
site
is
paramount,
leading
development
multifunctional
multicomponent
nanocomposites
thereby
emerging
as
promising
candidates
for
combination
therapy
treatment.
However,
currently
there
lack
systematic
analysis
reviews
focusing
on
AQ4N.
Herein,
this
review
provides
comprehensive
retrospect
recent
advancements
nanocomposites.
Specifically,
we
discuss
synergistic
effects
observed
chemotherapeutic
drugs,
radiotherapy,
phototherapy,
starvation,
sonodynamic
immunotherapy
preclinical
models.
Moreover,
advantages,
limitations,
future
perspectives
different
are
highlighted,
providing
researchers
from
diverse
fields
novel
insights
Язык: Английский