Molecules,
Год журнала:
2024,
Номер
29(21), С. 5023 - 5023
Опубликована: Окт. 24, 2024
The
deposition
of
amyloid
β-protein
(Aβ)
in
the
brain
is
main
pathogenesis
Alzheimer's
disease
(AD).
development
potent
inhibitors
against
Aβ
aggregation
one
effective
strategies
to
combat
AD.
Endogenous
transthyretin
(TTR)
can
inhibit
fibrillization
via
hydrophobic
interactions,
but
its
weak
inhibitory
potency
hinders
application
AD
therapy.
Here,
different
recombinant
TTRs
were
designed
by
cationic
surface
charge
engineering.
Compared
with
TTR,
all
positively
charged
showed
enhanced
capability
inhibiting
aggregation,
especially
protein
obtained
mutating
acidic
amino
acid
TTR
arginine
(TTR-nR)
exhibited
excellent
effect.
Among
them,
TTR-7R
remarkably
increased
Aβ,
which
could
effectively
Abstract
With
the
current
spread
of
clinically
relevant
multidrug-resistant
(MDR)
pathogens,
insufficient
unearthing
new
anti-infectives,
and
high
cost
required
for
approval
antimicrobial
agents,
a
strong
need
getting
these
agents
via
more
economic
other
alternative
routes
has
emerged.
discovery
biosynthetic
pathways
various
antibiotics
pointing
out
role
each
gene/protein
in
their
antibiotic-producing
strains,
it
became
apparent
that
gene
clusters
can
be
manipulated
to
produce
modified
antibiotics.
This
approach
is
known
as
combinatorial
biosynthesis
which
employed
obtaining
novel
derivatives
valuable
using
genetically
strains
(pathway
engineering).
In
this
review
based
on
available
major
aminoglycoside
(AGAs),
possible
alterations
or
modifications
could
done
by
co-expression
certain
gene(s)
previously
involved
unique
steps
have
been
discussed.
defined
examples
AGA
were
described
information
provided
will
act
platform
researchers
get
develop
bacterial
such
Streptomyces
,
Micromonospora
,…etc.
way,
with
biological
activities
isolated
used
treatment
infectious
diseases
conferring
resistance
existing
Metabolic
syndrome
(MetS)
is
a
complex
condition
characterized
by
abdominal
obesity,
insulin
resistance,
dyslipidemia,
and
hypertension,
all
of
which
increase
the
risk
cardiovascular
disease
type
2
diabetes.
The
gut
microbiome
plays
significant
role
in
metabolic
health,
influencing
digestion,
immune
function,
energy
metabolism.
When
microbiota
becomes
imbalanced
due
to
poor
diet
antibiotic
use,
it
can
lead
systemic
inflammation,
abnormal
lipid
metabolism,
are
central
features
MetS.
This
review
explores
connection
between
microbial
imbalances
MetS,
focusing
on
impact
health.
Supplementation
therapies
targeting
microbiome,
such
as
probiotics,
prebiotics,
synbiotics,
postbiotics,
evaluated
for
their
potential
improve
parameters
MetS
patients.
These
interventions
hold
promise
enhancing
sensitivity,
reducing
improving
profiles.
However,
further
research
needed
optimize
these
approaches
managing
Understanding
how
leverage
could
innovative,
non-invasive
treatments
this
growing
global
health
concern.
Molecules,
Год журнала:
2024,
Номер
29(21), С. 5023 - 5023
Опубликована: Окт. 24, 2024
The
deposition
of
amyloid
β-protein
(Aβ)
in
the
brain
is
main
pathogenesis
Alzheimer's
disease
(AD).
development
potent
inhibitors
against
Aβ
aggregation
one
effective
strategies
to
combat
AD.
Endogenous
transthyretin
(TTR)
can
inhibit
fibrillization
via
hydrophobic
interactions,
but
its
weak
inhibitory
potency
hinders
application
AD
therapy.
Here,
different
recombinant
TTRs
were
designed
by
cationic
surface
charge
engineering.
Compared
with
TTR,
all
positively
charged
showed
enhanced
capability
inhibiting
aggregation,
especially
protein
obtained
mutating
acidic
amino
acid
TTR
arginine
(TTR-nR)
exhibited
excellent
effect.
Among
them,
TTR-7R
remarkably
increased
Aβ,
which
could
effectively
