Free Radical Biology and Medicine, Год журнала: 2021, Номер 176, С. 203 - 221
Опубликована: Сен. 28, 2021
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(12), С. 6222 - 6222
Опубликована: Июнь 9, 2021
Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They supplied various amounts a diet, mainly from vegetable oils, some oilseeds, nuts. The main forms diet α- γ-tocopherol, due to highest content food products. Nevertheless, α-tocopherol is form vitamin E with tissue concentration. both tocopherols considered as most metabolically active. Currently, research results indicate also greater antioxidant potential than tocopherols. Moreover, biological role metabolites have received increasing interest. aim this review update knowledge tocopherol tocotrienol bioactivity, particular focus on their bioavailability, distribution, metabolism determinants humans. Almost one hundred years after start α-tocopherol, its properties still under investigation. For several decades, researchers’ interest importance other has been growing. Some functions, for instance functions γ-tocopherols, confirmed humans, while others, such relationship metabolic disorders, studies, which analyzed mechanisms over past few described new even unexpected cellular molecular that will be subject future research.
Язык: Английский
Процитировано
175
Chemico-Biological Interactions, Год журнала: 2022, Номер 368, С. 110170 - 110170
Опубликована: Окт. 3, 2022
Colon cancer affects both men and women is the world's second most significant cause of cancer-related mortality. death rates have risen worldwide due to current food habit lifestyle, which include a lot meat, alcohol, not enough physical exercise. As result, novel, less harmful pharmacological treatments for colon are needed now more than ever before. Colorectal (CRC) portion population. Chemotherapy's limits, as demonstrated by side effects resistance in CRC patients, being sought after despite recent breakthroughs that improved patient care survival. Numerous chemical compounds present medicinal herbs shown anti-tumor anti-apoptotic properties against various cancers, including CRC, animal experiments. These chemicals, come from several phytochemical families, activate signaling pathways. This article discusses research on anti-CRC benefits many plants conducted vitro, well components may play role study. Researchers also looking into impact these pathways involved signaling. According this review, be generated plants. That's why we're at how natural items can help treat while lowering risk developing it.
Язык: Английский
Процитировано
149
Evidence-based Complementary and Alternative Medicine, Год журнала: 2022, Номер 2022, С. 1 - 20
Опубликована: Апрель 11, 2022
The Brassicaceae family, known as cruciferous vegetables, includes many economically important species, mainly edible oil plants, vegetable spice and feed plants. Cruciferous vegetables are foods rich in nutritive composition also a good source of dietary fiber. Besides, contain various bioactive chemicals glucosinolates S-methyl cysteine sulfoxide, including sulphur-containing cancer-protective chemicals. Numerous studies have reported that daily intake sulphurous helps prevent cancer formation reduces incidence, especially colorectal cancer, through mechanisms. potential mechanisms these compounds preventing experimental follows: protecting cells against DNA damage, inactivating carcinogenic substances, showing antiviral antibacterial effects, triggering apoptosis with disrupted structure, inhibiting tumour cell migration causing metastasis the development tumour-feeding vessels (angiogenesis). These beneficial anticancer effects generally associated their some secondary metabolites, well other phenolic compounds, seed oils, fiber literature. This review aims to examine roles metabolites prevention treatment cancer.
Язык: Английский
Процитировано
113
Applied Sciences, Год журнала: 2025, Номер 15(4), С. 2047 - 2047
Опубликована: Фев. 15, 2025
Hypericum perforatum L., commonly known as St. John’s wort, is a widely distributed herbaceous plant utilized in traditional and phytomedicinal applications, particularly for its hydrophilic bioactive compounds. It often used treating early depressive states. In this study, we focused on reporting the tocotrienols—lipophilic phytochemicals with health-promoting properties—in wort. H. flowerheads predominantly contained tocotrienols compared tocopherols (54 30 mg/100 g dry weight, respectively). The major (T3) were δ-T3 α-T3 (34.0 17.6 Tocopherols are lipophilic that cannot be present wort water extracts (tea infusions), but they can recovered from remaining residues of tea infusions by using hydroethanolic solutions. A 50.0% (v/v) solution was not effective recovery tocochromanols. greatest increase extractability tocochromanols observed 70.0–80.0% extracts, while increasing ethanol concentration 90.0% to 96.2% only slightly improved (not statistically significant). For each concentration, proportionally higher than tocopherols. Residues proposed valuable by-products rich tocotrienols.
Язык: Английский
Процитировано
3
Nature Communications, Год журнала: 2020, Номер 11(1)
Опубликована: Сен. 8, 2020
Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 and analyze blood including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies immune cell profiling, complemented gut microbiota composition routine clinical chemistry. Overall, our results show high variation between across different readouts, while intra-individual baseline low. The analyses that each individual has unique stable plasma protein profile throughout study period many also distinct regards other omics datasets, strong underlying connections proteome chemistry parameters. In conclusion, support an individual-based definition health comprehensive profiling manner path forward for medicine.
Язык: Английский
Процитировано
130
Antioxidants, Год журнала: 2020, Номер 9(11), С. 1156 - 1156
Опубликована: Ноя. 20, 2020
The benevolent and detrimental effects of antioxidants are much debated in clinical trials cancer research. Several antioxidant enzymes molecules overexpressed oxidative stress conditions that can damage cellular proteins, lipids, DNA. Natural remove excess free radical intermediates by reducing hydrogen donors or quenching singlet oxygen delaying reactions actively growing cells. These agents have the potential to hinder progression only when administered at right proportions along with chemo-/radiotherapies. Antioxidants affect signal transduction energy metabolism pathways for maintenance redox status. A decline capacity arising from genetic mutations may increase mitochondrial flux radicals resulting misfiring signalling pathways. Often, a metabolic reprogramming these leads overproduction so called ’oncometabolites’ state ‘pseudohypoxia’. This inactivate several intracellular involved epigenetic regulations, thereby increasing giving rise growth advantages cancerous Undeniably, cell-type Reactive Oxygen Species (ROS) specific, which is manifested as changes enzyme activation, differences gene expression, functions well cell death mechanisms. Photodynamic therapy (PDT) using light-activated photosensitizing regulate balance accordance endogenous ROS production solution many challenges therapy.
Язык: Английский
Процитировано
127
Antioxidants, Год журнала: 2020, Номер 9(9), С. 865 - 865
Опубликована: Сен. 14, 2020
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid 2–related 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine Nrf2/Keap1) signaling. Unlike the genetic changes affecting DNA sequence, reversible nature epigenetic alterations provides an attractive avenue for cancer interception. Thus, targeting mechanisms in corresponding signaling networks represents enticing strategy therapeutic intervention with dietary phytochemicals acting at transcriptional, post-transcriptional, post-translational levels. This regulation involves interplay histone modifications methylation states human NFE2L2/KEAP1 Nfe2l2/Keap1 genes, acetylation lysine residues NRF2 Nrf2, interaction bromodomain extraterminal domain (BET) acetyl “reader” proteins, non-coding RNAs such as microRNA (miRNA) long RNA (lncRNA). Phytochemicals documented modulate act by reversing hypermethylated CpG islands NFE2L2 or Nfe2l2, via inhibition methyltransferases (DNMTs) deacetylases (HDACs), through induction ten-eleven translocation (TET) enzymes, inducing miRNA target 3′-UTR mRNA transcripts. To date, fewer than twenty have been reported modifiers, including curcumin, sulforaphane, resveratrol, reserpine, ursolic acid. opens avenues exploring additional that regulate epigenome, potential novel strategies view beneficial interception other chronic diseases.
Язык: Английский
Процитировано
79
Antioxidants, Год журнала: 2021, Номер 10(2), С. 205 - 205
Опубликована: Янв. 31, 2021
Breast cancer is the most frequent and leading cause of death in women. Oxidative stress generation reactive oxygen species (ROS) have been related to progression. Compared their normal counterparts, tumor cells show higher ROS levels tight regulation REDOX homeostasis maintain a low degree oxidative stress. Traditionally antioxidants extensively investigated counteract breast carcinogenesis progression as chemopreventive agents; however, there growing evidence indicating potential adjuvants for treatment cancer. Aimed elucidate whether could be reality management patients, this review focuses on latest investigations regarding ambivalent role development cancer, with special attention results derived from clinical trials, well use plausible agents combination therapy power ameliorate side effects attributed standard therapeutics. Data retrieved herein suggest that play an important prevention improvement therapeutic efficacy; nevertheless, appropriate patient stratification based “redoxidomics” or subtype mandatory order define dosage future standardized personalized treatments patients.
Язык: Английский
Процитировано
77
Antioxidants, Год журнала: 2022, Номер 11(9), С. 1785 - 1785
Опубликована: Сен. 9, 2022
A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of been unraveled in both cell and animal models, including antioxidant anti-inflammatory properties, well regulatory activities on signaling gene expression. However, the bioavailability physiological considerably shown to depend lifestyle, genetic factors, individual health conditions. Another important facet that has considered less so far is endogenous interaction with other nutrients. Accumulating evidence indicates between nutrients, especially those are enriched by supplementation humans, may explain at least some discrepancies observed clinical trials. Meanwhile, increasing suggests different forms metabolites derivates also exhibit activities, which more potent mediated via pathways compared respective precursors. In this review, possible molecular mechanisms nutritional factors discussed their potential impact pathophysiological processes evaluated using published co-supplementation studies.
Язык: Английский
Процитировано
51
Molecular Cancer, Год журнала: 2022, Номер 21(1)
Опубликована: Окт. 28, 2022
Brain cancer is regarded among the deadliest forms of worldwide. The distinct tumor microenvironment and inherent characteristics brain cells virtually render them resistant to majority conventional advanced therapies. Oxidative stress (OS) a key disruptor normal homeostasis involved in carcinogenesis different cancers. Thus, antioxidants may inhibit tumorigenesis by preventing OS induced various oncogenic factors. Antioxidants are hypothesized initiation endorsing DNA repair suppressing progression creating an energy crisis for preneoplastic cells, resulting antiproliferative effects. These effects referred as chemopreventive mediated antioxidant mechanism. In addition, minimize chemotherapy-induced nonspecific organ toxicity prolong survival. also support prooxidant chemistry that demonstrate chemotherapeutic potential, particularly at high or pharmacological doses trigger promoting free radical production, which essential activating cell death pathways. A growing body evidence revealed roles exogenous adjuvants their ability reverse chemoresistance. this review, we explain influences endogenous on cancers with reference roles. role metabolic reprogramming influence downstream signaling events suppressor gene mutations critically discussed. Finally, review both pro- anticancer mechanisms molecules killing neoplastic inhibiting recurrence followed treatments. requirements treatment under conditions discussed along reasons behind conflicting outcomes reports. mention influencing factors regulate pharmacology treatment. conclusion, achieve consistent clinical treatments cancers, rigorous mechanistic studies required respect types, forms, stages tumors. concomitant regimens need adequate consideration.
Язык: Английский
Процитировано
51