Cancer
is
a
daunting
global
health
problem
with
steadily
rising
incidence.
Despite
the
wide
arsenal
of
current
anticancer
therapies,
challenges
such
as
drug
resistance,
tumor
heterogeneity,
poor
targeting,
and
severe
side
effects
often
lead
to
suboptimal
efficacy
patient
outcomes,
highlighting
need
for
innovative
therapies.
Autophagy
modulation
has
emerged
an
attractive
approach
complement
existing
The
dual
role
autophagy
in
cancer
promotion
suppression
inspired
development
new
drugs
therapeutic
strategies
focusing
on
both
inhibition
induction.
promising
results
modulators
preclinical
studies,
lack
selectivity
potency,
toxicity,
pharmacokinetics,
inadequate
targeting
continue
limit
their
successful
clinical
translation.
Many
these
could
be
overcome
using
nanomedicine.
This
review
explores
recent
advancements
nanomedicine
modulation.
Successful
combination
leveraging
nanoparticles
synergy
chemotherapy,
immunotherapy,
phototherapy,
gene
therapy,
other
modalities
are
presented.
Additionally,
nanomaterials
intrinsic
autophagy‐modulating
capabilities,
self‐assembling
inhibitors,
discussed.
Finally,
limitations
currently
trials
discussed,
future
perspectives
designing
implementation
explored.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 189 - 189
Опубликована: Март 14, 2025
Multiple
lines
of
evidence
suggest
that
multiple
pathological
conditions
and
diseases
account
for
the
majority
human
mortality
are
driven
by
molecular
aging
process.
At
cellular
level,
can
largely
be
conceptualized
to
comprise
progressive
accumulation
damage,
leading
resultant
dysfunction.
As
many
diseases,
e.g.,
cancer,
coronary
heart
disease,
Chronic
obstructive
pulmonary
Type
II
diabetes
mellitus,
or
chronic
kidney
potentially
share
a
common
etiology,
then
identification
such
mechanisms
may
represent
an
ideal
locus
develop
targeted
prophylactic
agents
mitigate
this
disease-driving
mechanism.
Here,
using
input
artificial
intelligence
systems
generate
unbiased
disease
mechanism
profiles,
we
have
aimed
identify
key
signaling
new
disease-preventing
pathways
creation
chemical
interventions.
Using
combinatorial
informatics
approach,
identified
potential
critical
involving
recently
kinase,
Dual
specificity
tyrosine-phosphorylation-regulated
kinase
3
(DYRK3)
epidermal
growth
factor
receptor
(EGFR)
function
as
regulator
transition
health
into
via
control
fate
in
response
stressful
insults.
Cancer
is
a
daunting
global
health
problem
with
steadily
rising
incidence.
Despite
the
wide
arsenal
of
current
anticancer
therapies,
challenges
such
as
drug
resistance,
tumor
heterogeneity,
poor
targeting,
and
severe
side
effects
often
lead
to
suboptimal
efficacy
patient
outcomes,
highlighting
need
for
innovative
therapies.
Autophagy
modulation
has
emerged
an
attractive
approach
complement
existing
The
dual
role
autophagy
in
cancer
promotion
suppression
inspired
development
new
drugs
therapeutic
strategies
focusing
on
both
inhibition
induction.
promising
results
modulators
preclinical
studies,
lack
selectivity
potency,
toxicity,
pharmacokinetics,
inadequate
targeting
continue
limit
their
successful
clinical
translation.
Many
these
could
be
overcome
using
nanomedicine.
This
review
explores
recent
advancements
nanomedicine
modulation.
Successful
combination
leveraging
nanoparticles
synergy
chemotherapy,
immunotherapy,
phototherapy,
gene
therapy,
other
modalities
are
presented.
Additionally,
nanomaterials
intrinsic
autophagy‐modulating
capabilities,
self‐assembling
inhibitors,
discussed.
Finally,
limitations
currently
trials
discussed,
future
perspectives
designing
implementation
explored.
