Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 13, 2024
Pyroptosis
is
a
form
of
inflammatory
programmed
cell
death,
and
activated
by
pathogen
infections
or
endogenous
danger
signals.
The
canonical
pyroptosis
process
characterized
the
inflammasome
(typically
NLRP3)-mediated
activation
caspase-1,
which
in
turn
cleaves
activates
IL-1β
IL-18,
as
well
gasdermin
D,
pore-forming
executor
protein,
leading
to
membrane
rupture,
release
proinflammatory
cytokines
damage-associated
molecular
pattern
molecules.
considered
part
innate
immune
response.
A
certain
level
can
help
eliminate
pathogenic
microorganisms,
but
excessive
lead
persistent
responses,
cause
tissue
damage.
In
recent
years,
has
emerged
crucial
contributor
development
chronic
respiratory
diseases,
such
asthma.
present
study
reviews
involvement
asthma,
terms
its
role
different
phenotypes
disease,
influence
on
various
non-immune
cells
airway.
addition,
potential
therapeutic
value
targeting
for
treatment
specific
asthma
discussed.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(16), С. 12877 - 12877
Опубликована: Авг. 17, 2023
Psychological
stress
is
widely
acknowledged
as
a
major
contributor
to
immunosuppression,
rendering
individuals
more
susceptible
various
diseases.
The
complex
interplay
between
the
nervous,
endocrine,
and
immune
systems
underlies
stress-induced
immunosuppression.
However,
underlying
mechanisms
of
psychological-stress-induced
immunosuppression
remain
unclear.
In
this
study,
we
utilized
restraint
mouse
model
known
for
its
suitability
in
investigating
physiological
regulations
during
psychological
stress.
Comparing
it
with
cold
exposure,
observed
markedly
elevated
levels
hormones
corticosterone
cortisol
plasma
mice
subjected
Furthermore,
restraint-stress-induced
differed
from
intravenous
immunoglobulin-like
leading
increased
macrophage
cell
death
spleen.
Suppression
pyroptosis
through
treatments
inflammasome
inhibitors
ameliorated
spleen
infiltration
macrophages
mice.
These
findings
suggest
that
associated
may
contribute
immunosuppressive
effects.
insights
have
implications
development
targeting
emphasizing
need
further
investigation
into
mechanisms.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(10), С. 4195 - 4227
Опубликована: Июнь 28, 2024
Cell
death
is
a
central
process
for
organismal
health.
Pyroptosis,
namely
pyroptotic
cell
death,
recognized
as
critical
type
that
disrupts
membrane
and
triggers
pro-inflammatory
cytokine
secretion
Allergy,
Год журнала:
2024,
Номер
79(9), С. 2380 - 2395
Опубликована: Июль 14, 2024
Pyroptosis
is
an
inflammatory
form
of
programmed
cell
death
that
distinct
from
necrosis
and
apoptosis.
primarily
mediated
by
the
gasdermin
family
proteins
(GSDMA-E
PVJK),
which,
when
activated
proteolytic
cleavage,
pores
in
plasma
membrane,
leading
to
death.
While
much
past
research
on
pyroptosis
has
focused
its
role
cancer,
metabolic
disorders,
infectious
diseases,
recent
experimental
observational
studies
have
begun
implicate
allergic
diseases.
These
suggest
gasdermin-mediated
contributes
development
conditions
could
offer
novel
targets
for
therapy.
Here,
we
review
our
current
understanding
with
emphasis
gasdermins
as
executioners
potential
mediators
disease.
We
highlight
new
discoveries
establish
a
mechanistic
link
between
biochemical
actions
onset
Additionally,
discuss
how
might
contribute
dysfunction
epithelial
barrier,
key
factor
believed
initiate
progression
various
Pyroptosis
may
play
an
important
role
in
the
resistance
of
ovarian
cancer
(OC)
to
chemotherapy.
However,
mechanism
by
which
pyroptosis
modulation
can
attenuate
chemotherapy
has
not
been
comprehensively
studied
OC.
Here,
we
demonstrated
that
RAS-associated
C3
botulinum
toxin
substrate
1
(RAC1)
is
highly
expressed
OC
and
negatively
correlated
with
patient
outcomes.
Through
cell
function
tests
vivo
tumor
formation
tests,
found
RAC1
promote
growth
mediating
paclitaxel
(PTX)
resistance.
mediate
progression
inhibiting
pyroptosis,
as
evidenced
high-throughput
automated
confocal
imaging,
release
lactate
dehydrogenase
(LDH),
expression
inflammatory
cytokines
IL-1β/IL-18
nucleotide
oligomerization
domain-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
inflammasome.
Mechanically,
RNA-seq,
gene
set
enrichment
analysis
(GSEA),
coimmunoprecipitation
(Co-IP),
mass
spectrometry
(MS),
ubiquitination
further
confirmed
inhibits
caspase-1/gasdermin
D
(GSDMD)-mediated
canonical
through
P21-activated
kinase
4
(PAK4)/mitogen-activated
protein
(MAPK)
pathway,
thereby
promoting
PTX
cells.
Finally,
whole
molecular
pathway
was
verified
results
drug
combination
clinical
specimen
detection
prognosis.
In
summary,
our
suggest
inhibitors
reverse
inducing
PAK4/MAPK
pathway.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 13, 2024
Pyroptosis
is
a
form
of
inflammatory
programmed
cell
death,
and
activated
by
pathogen
infections
or
endogenous
danger
signals.
The
canonical
pyroptosis
process
characterized
the
inflammasome
(typically
NLRP3)-mediated
activation
caspase-1,
which
in
turn
cleaves
activates
IL-1β
IL-18,
as
well
gasdermin
D,
pore-forming
executor
protein,
leading
to
membrane
rupture,
release
proinflammatory
cytokines
damage-associated
molecular
pattern
molecules.
considered
part
innate
immune
response.
A
certain
level
can
help
eliminate
pathogenic
microorganisms,
but
excessive
lead
persistent
responses,
cause
tissue
damage.
In
recent
years,
has
emerged
crucial
contributor
development
chronic
respiratory
diseases,
such
asthma.
present
study
reviews
involvement
asthma,
terms
its
role
different
phenotypes
disease,
influence
on
various
non-immune
cells
airway.
addition,
potential
therapeutic
value
targeting
for
treatment
specific
asthma
discussed.
