Epigenetic modifications in obesity‐associated diseases
MedComm,
Год журнала:
2024,
Номер
5(2)
Опубликована: Фев. 1, 2024
The
global
prevalence
of
obesity
has
reached
epidemic
levels,
significantly
elevating
the
susceptibility
to
various
cardiometabolic
conditions
and
certain
types
cancer.
In
addition
causing
metabolic
abnormalities
such
as
insulin
resistance
(IR),
elevated
blood
glucose
lipids,
ectopic
fat
deposition,
can
also
damage
pancreatic
islet
cells,
endothelial
cardiomyocytes
through
chronic
inflammation,
even
promote
development
a
microenvironment
conducive
cancer
initiation.
Improper
dietary
habits
lack
physical
exercise
are
important
behavioral
factors
that
increase
risk
obesity,
which
affect
gene
expression
epigenetic
modifications.
Epigenetic
alterations
occur
in
early
stage
some
reversible,
while
others
persist
over
time
lead
obesity-related
complications.
Therefore,
dynamic
adjustability
modifications
be
leveraged
reverse
obesity-associated
diseases
interventions,
drugs,
bariatric
surgery.
This
review
provides
comprehensive
summary
impact
regulation
on
initiation
cancers,
type
2
diabetes,
cardiovascular
diseases,
establishing
theoretical
basis
for
prevention,
diagnosis,
treatment
these
conditions.
Язык: Английский
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity
Nature Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Type 2 Diabetes Mellitus: A Comprehensive Review of Pathophysiology, Comorbidities, and Emerging Therapies
Comprehensive physiology,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 1, 2025
ABSTRACT
Humans
are
perhaps
evolutionarily
engineered
to
get
deeply
addicted
sugar,
as
it
not
only
provides
energy
but
also
helps
in
storing
fats,
which
survival
during
starvation.
Additionally,
sugars
(glucose
and
fructose)
stimulate
the
feel‐good
factor,
they
trigger
secretion
of
serotonin
dopamine
brain,
associated
with
reward
sensation,
uplifting
mood
general.
However,
when
consumed
excess,
contributes
imbalance,
weight
gain,
obesity,
leading
onset
a
complex
metabolic
disorder,
generally
referred
diabetes.
Type
2
diabetes
mellitus
(T2DM)
is
one
most
prevalent
forms
diabetes,
nearly
affecting
all
age
groups.
T2DM
clinically
diagnosed
cardinal
sign
chronic
hyperglycemia
(excessive
sugar
blood).
Chronic
hyperglycemia,
coupled
dysfunctions
pancreatic
β‐cells,
insulin
resistance,
immune
inflammation,
further
exacerbate
pathology
T2DM.
Uncontrolled
T2DM,
major
public
health
concern,
significantly
toward
progression
several
micro‐
macrovascular
diseases,
such
diabetic
retinopathy,
nephropathy,
neuropathy,
atherosclerosis,
cardiovascular
including
cancer.
The
current
review
discusses
epidemiology,
causative
factors,
pathophysiology,
comorbidities,
existing
emerging
therapies
related
It
future
roadmap
for
alternative
drug
discovery
management
Язык: Английский
From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections
Reviews in Endocrine and Metabolic Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Abstract
The
prostate
gland
is
an
endocrine-sensitive
organ
responding
to
multiple
stimuli.
Its
development
and
function
are
regulated
by
hormones
(i.e.
steroids
such
as
androgens,
estrogens
glucocorticoids)
but
also
other
key
hormonal
systems
those
comprised
insulin-like
growth
factor
1
insulin,
which
sourced
different
tissues
[e.g.
testicles/adrenal-gland/adipose-tissue/liver/pancreas,
etc.).
Particularly
important
for
the
endocrine
control
of
prostatic
pathophysiology
anatomy
produced
and/or
secreted
cell
types
pituitary
[growth-hormone,
luteinizing-hormone,
follicle-stimulating
hormone,
prolactin,
oxytocin,
arginine-vasopressin
melanocyte-stimulating
hormone],
affect
either
directly
or
indirectly
under
physiological
pathophysiological
conditions
metabolic
dysregulation
(e.g.
obesity),
transformations
cancer)].
This
review
summarizes
impact
all
hormone
on
these
diverse
including
in
vivo
vitro
studies.
Язык: Английский
Metabolic Memory in Obesity: Can Early-Life Interventions Reverse Lifelong Risks?
Obesity Medicine,
Год журнала:
2025,
Номер
unknown, С. 100610 - 100610
Опубликована: Апрель 1, 2025
Язык: Английский
Obesity and Cancer: Excess Body Fat as a Risk Factor in Carcinogenesis; Consequences Across Human Body Systems and Significance for Associated Medical Specialties
European Journal of Medical and Health Research,
Год журнала:
2025,
Номер
3(2), С. 122 - 135
Опубликована: Март 23, 2025
Obesity
is
a
known
risk
factor
for
various
cancers,
influencing
carcinogenesis
through
metabolic,
hormonal,
and
inflammatory
pathways.
Excess
adiposity
leads
to
insulin
resistance,
chronic
inflammation,
hormonal
imbalances,
all
of
which
contribute
tumor
development.
increases
the
cancers
in
endocrine
system
(e.g.,
thyroid,
pancreatic,
adrenal)
due
resistance
altered
hormone
levels.
In
reproductive
system,
it
raises
breast,
ovarian,
endometrial,
prostate
dysregulation
inflammation.
also
linked
digestive
including
esophageal,
liver,
colorectal
metabolic
dysfunction
The
role
obesity
lung
cancer
remains
debated,
but
changes
may
influence
progression.
contributes
hematologic
such
as
leukemia,
by
altering
immune
function
promoting
Other
systems
show
varying
associations
with
risk.
Key
mechanisms
include
dysregulation,
epigenetic
changes,
elevated
insulin/IGF-1,
promote
growth.
Early
detection
imaging
biomarkers,
along
lifestyle
diet,
exercise)
pharmacologic
treatments
metformin,
GLP-1
agonists),
can
reduce
improve
outcomes.
Personalized
treatment
obese
patients
requires
adjustments
surgery,
chemotherapy,
radiotherapy,
immunotherapy.
This
review
explores
obesity’s
association
across
body
systems,
overviews
contributing
carcinogenesis,
summarizes
clinical
public
health
implications,
screening,
prevention,
treatment,
policy
interventions.
Язык: Английский
Mitochondrial RNA methylation in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(6), С. 189213 - 189213
Опубликована: Ноя. 1, 2024
Язык: Английский
Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link
Journal of the National Cancer Center,
Год журнала:
2024,
Номер
5(1), С. 8 - 27
Опубликована: Ноя. 28, 2024
Язык: Английский
The Role of Epigenetic Modifications in Cellular Differentiation and the Development of Complex Diseases
Next frontier.,
Год журнала:
2024,
Номер
8(1), С. 199 - 199
Опубликована: Ноя. 28, 2024
Epigenetic
modifications
play
a
pivotal
role
in
cellular
differentiation
and
the
onset
of
complex
diseases
by
regulating
gene
expression
without
altering
underlying
DNA
sequence.
Mechanisms
such
as
methylation,
histone
modification,
chromatin
remodeling
orchestrate
transition
from
pluripotent
stem
cells
to
specialized
cell
types,
ensuring
tissue-specific
functionality.
This
research
delves
into
intricate
interplay
between
these
epigenetic
regulators
their
involvement
developmental
processes.
Moreover,
it
examines
how
aberrations
landscapes
contribute
pathogenesis
cancer,
neurodegenerative
disorders,
autoimmune
conditions.
By
employing
advanced
techniques
like
single-cell
epigenomics
CRISPR-based
editing,
this
study
aims
uncover
novel
biomarkers
therapeutic
targets.
The
findings
highlight
dynamic
reversible
nature
marks,
offering
promising
avenues
for
personalized
medicine.
Understanding
disease
development
is
essential
advancing
diagnostics,
therapeutics,
our
broader
understanding
human
biology.
Язык: Английский