Current clinical findings of acute neurological syndromes after SARS‐CoV‐2 infection
MedComm,
Год журнала:
2024,
Номер
5(3)
Опубликована: Март 1, 2024
Abstract
Neuro‐COVID,
a
condition
marked
by
persistent
symptoms
post‐COVID‐19
infection,
notably
affects
various
organs,
with
particular
focus
on
the
central
nervous
system
(CNS).
Despite
scant
evidence
of
SARS‐CoV‐2
invasion
in
CNS,
increasing
incidence
Neuro‐COVID
cases
indicates
onset
acute
neurological
early
infection.
The
Omicron
variant,
distinguished
heightened
neurotropism,
penetrates
CNS
via
olfactory
bulb.
This
direct
induces
inflammation
and
neuronal
damage,
emphasizing
need
for
vigilance
regarding
potential
complications.
Our
multicenter
study
represents
groundbreaking
revelation,
documenting
definite
presence
cerebrospinal
fluid
(CSF)
significant
proportion
patients.
Furthermore,
notable
differences
emerged
between
RNA‐CSF‐positive
negative
patients,
encompassing
aspects
such
as
blood–brain
barrier
integrity,
extent
activation
status
inflammation.
inherent
limitations,
this
research
provides
pivotal
insights
into
intricate
interplay
underscoring
necessity
ongoing
to
fully
comprehend
virus's
enduring
effects
CNS.
findings
underscore
urgency
continuous
investigation
unravel
complexities
relationship,
addressing
long‐term
consequences
COVID‐19
health.
Язык: Английский
Epidemiological Characteristics of Neuro‐Specific Antibodies Following Viral Infections
Journal of Medical Virology,
Год журнала:
2024,
Номер
96(11)
Опубликована: Ноя. 1, 2024
ABSTRACT
This
study
aims
to
explore
the
epidemiological
characteristics
of
neuro‐specific
antibodies
(ns‐Ab)
induced
by
different
viral
infections
within
central
nervous
system
(CNS).
Additionally,
it
seeks
compare
autoimmune
effects
following
several
typical
in
CNS.
We
conduct
a
retrospective
and
analyze
prevalence
trends
ns‐Ab
patients
with
infections.
evaluate
intensity
CNS
inflammatory
responses
postviral
infection
correlating
clinical
laboratory
findings,
briefly
demonstrate
immune
various
retrospectively
collected
data
from
1037
hospitalized
suspected
A
total
654
(63.1%)
were
included
final
analysis.
higher
proportion
pathogens
present
their
cerebrospinal
fluid
(CSF)
(114
out
332,
34.3%)
tested
positive
for
compared
those
without
(70
322,
21.7%)
(
p
=
0.0004).
Specifically,
screening
rate
(83
165,
50.3%)
(27
83,
32.5%)
significantly
than
other
pathogen
<
0.0001
0.016,
respectively).
Among
these,
human
herpesvirus
7
(HHV7)
had
highest
detection
during
disease
course
(11
26,
42.3%),
but
exhibited
distinctly
herpes
simplex
virus
1
(HSV1).
Viral
promote
development
The
production
subsequent
response
vary
across
There
is
strong
statistical
correlation
between
HHV7
presence
ns‐Ab,
suggesting
that
may
serve
as
an
early
indicator
secondary
Язык: Английский