Vidyodaya Journal of Science,
Год журнала:
2024,
Номер
27(02)
Опубликована: Дек. 30, 2024
Nanozymes,
artificial
nanomaterials
mimicking
enzyme
activity,
are
at
the
forefront
of
innovative
cancer
therapies,
particularly
in
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
and
photothermal
(PTT).
Their
capacity
to
selectively
generate
reactive
oxygen
species
under
tumor-specific
conditions,
including
low
pH
high
H₂O₂
levels,
facilitates
targeted
induction
cell
death
while
minimizing
damage
healthy
tissues.
When
integrated
with
PDT
or
PTT,
nanozymes
enhance
oxidative
stress
promote
immunogenic
death,
further
amplifying
anti-tumor
immune
responses.
Recent
advances
single-atom
intelligent
have
shown
promise
overcoming
therapeutic
limitations,
such
as
tumor
hypoxia
suppression
modulating
microenvironment
boost
treatment
efficacy.
Additionally,
ongoing
preclinical
clinical
evaluations
highlight
potential
synergistically
immunotherapy
outcomes.
advantages
over
traditional
enzymes,
stability,
tunability,
cost-effectiveness,
ability
maintain
catalytic
activity
hostile
environments,
position
transformative
agents
therapy.
However,
their
translation
faces
significant
challenges,
biocompatibility
concerns,
delivery
inefficiencies
sites,
stringent
regulatory
hurdles,
which
require
comprehensive
research
solutions
address.
Despite
these
advancements
nanozyme
design
functionalization
continue
pave
way
for
more
effective
safer
applications
will
be
discussed
detail
this
review.Keywords:
Cancer
therapy,
Nanomaterial,
ROS,
(PTT)
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Biological
carriers
have
emerged
as
significant
tools
to
deliver
radionuclides
in
nuclear
medicine,
providing
a
meaningful
perspective
for
tumor
imaging
and
treatment.
Various
radionuclide-labeled
biological
been
developed
meet
the
needs
of
biomedical
applications.
This
review
introduces
principles
radionuclide-mediated
therapy
selected
criteria
them,
well
comprehensive
description
characteristics
functions
representative
including
bacteria,
cells,
viruses,
their
derivatives,
emphasizing
labeled
strategies
combined
with
radionuclides.
Subsequently,
we
in-depth
introduce
application
treatment,
behaviors
vivo
metastasis
treatment
by
radionuclide
therapy,
plus
other
radiation-induced
photodynamic
therapy.
Finally,
challenges
prospects
are
discussed
improve
shortcomings
this
innovative
platform
promote
clinical
transformation
field
medical
imaging.
Molecules,
Год журнала:
2025,
Номер
30(4), С. 884 - 884
Опубликована: Фев. 14, 2025
Researchers
have
extensively
investigated
photosensitizer
(PS)
derivatives
for
various
applications
due
to
their
superior
photophysical
and
electrochemical
properties.
However,
inherent
problems,
such
as
instability
self-quenching
under
physiological
conditions,
limit
biological
applications.
Metal-organic
frameworks
(MOFs)
covalent
organic
(COFs)
represent
two
relatively
new
material
types.
These
materials
high
surface
areas
permanent
porosity,
they
show
a
tremendous
deal
of
potential
like
these.
This
review
summarizes
key
synthesis
processes
highlights
recent
advancements
in
integrating
PS-based
COF
MOF
nanocarriers
biomedical
while
addressing
obstacles
prospects.
Molecular Biomedicine,
Год журнала:
2024,
Номер
5(1)
Опубликована: Окт. 17, 2024
It
has
long
been
widely
acknowledged
that
ultraviolet
(UV)
light
is
an
environment
risk
factor
can
lead
to
cancer,
particularly
skin
cancer.
However,
it
worth
noting
UV
radiation
holds
potential
for
cancer
treatment
as
a
relatively
high-energy
electromagnetic
wave.
With
the
help
of
nanomaterials,
role
caught
increasing
attention
in
treatment.
In
this
review,
we
briefly
summarized
types
UV-induced
cancers,
including
malignant
melanoma,
squamous
cell
carcinoma,
basal
Merkel
carcinoma.
Importantly,
discussed
primary
mechanisms
underlying
carcinogenesis,
mutations
by
DNA
damage,
immunosuppression,
inflammation
and
epigenetic
alterations.
Historically
limited
its
shallow
penetration
depth,
introduction
nanomaterials
dramatically
transformed
utilization
The
direct
effect
itself
generally
leads
suppression
growth
initiation
apoptosis
ferroptosis.
also
be
utilized
activate
photosensitizers
reactive
oxygen
species
(ROS)
production,
sensitize
radiotherapy
achieve
controlled
drug
release.
Finally,
comprehensively
weigh
significant
risks
limitations
associated
with
therapeutic
use
radiation.
And
contradictory
exposure
promoting
inhibiting
tumor
discussed.
This
review
provides
clues
clinical
therapy
well
future
study
directions
field.
precise
delivery
control
or
wavelength
dose
effects
are
needed
thorough
understanding
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1188 - 1188
Опубликована: Сен. 8, 2024
Skin
and
soft-tissue
infections
require
significant
consideration
because
of
their
prolonged
treatment
duration
propensity
to
rapidly
progress,
resulting
in
severe
complications.
The
primary
challenge
stems
from
the
involvement
drug-resistant
microorganisms
that
can
form
impermeable
biofilms,
as
well
possibility
infection
extending
deep
into
tissues,
thereby
complicating
drug
delivery.
Dissolving
microneedle
patches
are
an
innovative
transdermal
drug-delivery
system
effectively
enhances
penetration
through
stratum
corneum
barrier,
increasing
concentration
at
site
infection.
They
offer
highly
efficient,
safe,
patient-friendly
alternatives
conventional
topical
formulations.
This
comprehensive
review
focuses
on
recent
advances
emerging
trends
dissolving-microneedle
technology
for
antimicrobial
skin-infection
therapy.
Conventional
antibiotic
microneedles
compared
with
those
based
agents,
such
quorum-sensing
inhibitors,
peptides,
antimicrobial-matrix
materials.
also
highlights
potential
incorporating
chemodynamic,
nanoenzyme
antimicrobial,
photodynamic,
photothermal
antibacterial
therapies.
explores
advantages
various
therapies
emphasizes
combined
application
improve
efficacy
microneedles.
Finally,
this
analyzes
druggability
different
discusses
possible
future
developments.
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Among
various
cancer
treatment
methods,
photodynamic
therapy
has
received
significant
attention
due
to
its
non-invasiveness
and
high
efficiency
in
inhibiting
tumour
growth.
Recently,
specific
organelle
targeting
photosensitizers
have
increasing
interest
their
precise
accumulation
ability
trigger
organelle-mediated
cell
death
signalling
pathways,
which
greatly
reduces
the
drug
dosage,
minimizes
toxicity,
avoids
multidrug
resistance,
prevents
recurrence.
In
this
review,
recent
advances
representative
used
targeted
on
organelles,
specifically
including
endoplasmic
reticulum,
Golgi
apparatus,
mitochondria,
nucleus,
lysosomes,
been
comprehensively
reviewed
with
a
focus
structure
pathways.
Furthermore,
perspective
future
research
potential
challenges
precision
presented
at
end.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Enveloped
viruses,
such
as
flaviviruses
and
coronaviruses,
are
pathogens
of
significant
medical
concern
that
cause
severe
infections
in
humans.
Some
photosensitizers
known
to
possess
virucidal
activity
against
enveloped
targeting
their
lipid
bilayer.
Here
we
report
a
series
halogenated
difluoroboron-dipyrromethene
(BODIPYs)
with
strong
virus-inactivating
activity.
Our
structure–activity
relationship
analysis
revealed
BODIPY
scaffolds
heavy
halogen
atom
demonstrate
efficacy
both
tick-borne
encephalitis
virus
(TBEV;
Flaviviridae
family)
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2;
Coronaviridae
along
high
singlet
oxygen
quantum
yields.
Moreover,
select
compounds
also
inactivated
other
herpes
simplex
type
1
monkeypox
virus.
The
nature
length
the
alkyl
side
chain
notably
influenced
molecules.
Furthermore,
molecular
dynamics
studies
highlighted
critical
importance
positioning
chromophore
moiety
within
As
membrane-targeting
photosensitizers,
BODIPYs
interact
directly
particles,
causing
damage
viral
envelope
membranes.
Thus,
TBEV
pretreated
was
completely
noninfective
for
lab
mice.
Consequently,
BODIPY-based
hold
potential
either
broad-spectrum
antivirals
variety
phylogenetically
unrelated
viruses
or
potent
inactivators
development
vaccines
preventing
life-threatening
emerging
diseases.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Polymer-based
photosensitizers
have
found
various
applications
in
photodynamic
therapy
(PDT).
However,
the
absence
of
targeting
ability
commonly
results
a
substantial
reduction
photosensitizer
accumulation
at
tumor
site,
significantly
limiting
therapeutic
efficacy
system.
In
addition,
development
biodegradable
polymeric
is
critical
importance
for
biological
applications.
this
work,
we
present
guanidine-functionalized
based
on
poly(trimethylene
carbonate)
(PTMC)
block
copolymers,
which
can
self-assemble
into
polymersomes.
The
presence
guanidine
groups
surface
polymersomes
enhance
cellular
uptake
efficiency
photosensitizers,
thereby
improving
intracellular
production
reactive
oxygen
species
(ROS).
vitro
study
demonstrates
that
guanidinylated
polymersome
promote
killing
cancer
cells
compared
to
unfunctionalized
light
irradiation.
PTMC-based
with
integration
cell-targeting
and
biodegradability,
are
anticipated
provide
novel
strategy
developing
advanced
biomedical
polymer
systems
PDT.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 741 - 770
Опубликована: Янв. 1, 2025
Different
types
of
cancers
affect
the
gastrointestinal
tract
(GIT),
starting
from
oral
cavity
and
extending
to
colon.
In
general,
most
current
research
focuses
on
systemic
delivery
therapeutic
agents,
which
leads
undesired
side
effects
a
limited
enhancement
in
outcomes.
As
result,
localized
within
(GI)
is
favorable
overcoming
these
limitations.
However,
via
administration
faces
many
challenges
related
complex
structure
GIT
(varied
pH
levels
transit
times)
as
well
harsh
environment
tumor
cells
(hypoxia,
efflux
pumps,
acidity).
To
overcome
obstacles,
nano-drug
systems
(NDDs)
have
been
designed
proved
their
potential
by
exploiting
favor
offering
specific
desired
target.
The
review
begins
with
an
overview
different
GI
impact
globally.
Then,
it
discusses
treatment
approaches
corresponding
Additionally,
associated
drug
for
are
summarized.
Finally,
detail
recent
diagnostic
applications
NDDs
that
conducted
oral,
esophageal,
gastric,
colon,
liver
cancers,
aiming
offer
valuable
insights
into
future
state
utilizing
local
cancers.
Photochemistry and Photobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Photodynamic
therapy
(PDT)
has
shown
promise
as
an
adjuvant
treatment
for
malignant
pleural
mesothelioma
when
combined
with
surgical
resection.
Accurate
light
dosimetry
is
critical
efficacy.
This
study
presents
improved
method
analyzing
fluence
distribution
in
PDT
using
a
standardized
anatomical
coordinate
system
and
advanced
computational
modeling.
We
utilized
infrared
navigation
delivery
wand
to
track
real‐time.
The
human
chest
cavity
geometry
was
reconstructed
the
pleura
mapped
system,
allowing
direct
comparisons
across
patients.
Light
calculated
both
primary
scattered
components,
novel
dual
correction
applied
match
measured
values
at
detector
locations.
approach
allowed
statistical
analysis
of
regions
cohort
11
Results
showed
acceptable
uniformity
standard
deviation
6.6%
from
prescribed
dose
comprehensive
provides
insights
optimizing
protocols
lays
groundwork
future
studies
on
singlet
oxygen
generation
its
correlation
outcomes
PDT.
