Design, synthesis, and biological evaluation of quinolinyl-ureido-phenyl-hydrazide derivatives and quinolinyl-hydrazide derivatives as anticancer agents targeting Nur77-mediated ferroptosis
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 117559 - 117559
Опубликована: Апрель 1, 2025
Язык: Английский
A transcriptomic analysis of the interplay of ferroptosis and immune filtration in endometriosis and identification of novel therapeutic targets
Computational Biology and Chemistry,
Год журнала:
2025,
Номер
115, С. 108343 - 108343
Опубликована: Янв. 7, 2025
Язык: Английский
Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 265 - 265
Опубликована: Янв. 22, 2025
Ferroptosis,
characterized
by
iron
dependency
and
lipid
peroxidation,
has
emerged
as
a
key
mechanism
underlying
neurodegeneration
in
rare
neurological
disorders.
These
conditions,
often
marked
significant
therapeutic
gaps
high
unmet
medical
needs,
present
unique
challenges
for
intervention
development.
This
review
examines
the
involvement
of
ferroptosis
disease
pathogenesis,
focusing
on
its
role
oxidative
damage
neuronal
dysfunction.
We
explore
recent
pharmacological
advancements,
including
chelators,
peroxidation
blockers,
antioxidant-based
strategies,
designed
to
target
ferroptosis.
While
these
approaches
show
promise,
such
heterogeneity,
limited
diagnostic
tools,
small
patient
cohorts
hinder
progress.
Furthermore,
we
discuss
translational
regulatory
barriers
implementing
ferroptosis-based
therapies
clinical
practice.
By
addressing
obstacles
fostering
innovative
solutions,
this
underscores
potential
ferroptosis-targeting
strategies
revolutionize
treatment
paradigms
Язык: Английский
Integrative Proteomics and Metabolomics Approach to Elucidate the Cardiotoxicity of Decabromodiphenyl Ethane in Zebrafish Larvae
Опубликована: Янв. 1, 2025
Язык: Английский
Anti-Inflammatory Effects of Curcumin-Based Nanoparticles Containing α-Linolenic Acid in a Model of Psoriasis In Vitro
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 692 - 692
Опубликована: Фев. 14, 2025
Background/Objectives.
Psoriasis
is
a
common
chronic
skin
inflammatory
disorder
pathogenetically
associated
with
genetic,
environmental,
and
immunological
factors.
The
hallmarks
of
psoriatic
lesions
include
sustained
inflammation
related
to
alterations
in
the
innate
adaptive
immune
response,
uncontrolled
keratinocyte
proliferation,
differentiation,
death,
as
well
dysregulated
crosstalk
between
cells
keratinocytes.
In
search
novel
therapeutic
strategies
based
on
use
natural
products
dietary
components
combine
available
conventional
innovative
therapeutics,
we
explored
anti-inflammatory,
antioxidant,
immunomodulatory
activities
Curcumin
(CU)-based
solid
lipid
nanoparticles
(SLNs)
carrying
omega-3
fatty
acid
linolenic
(LNA)
an
vitro
model
psoriasis
that
had
been
previously
constructed
characterized
by
us.
Methods.
This
consists
differentiated
THP-1
macrophages
(Mφs)
NCTC-2544
keratinocytes
exposed
or
not
conditioned
medium
(CM)
from
Mφs
treated
Toll-like
receptor-7
ligand
imiquimod
(IMQ).
Results.
Mφs,
treatment
CU-LNA-SLNs
inhibited
IMQ-induced
expression
proinflammatory
cytokines
(IL-23,
IL-8,
IL-6:
43%,
26.5%
73.7%
inhibition,
respectively,
vs
IMQ-treated
Mφs),
hyperproliferative
response
(12.8%
inhibition
Mφs)
increase
cell
death
observed
Mφ-derived
CM
(64.7%
inhibition).
Moreover,
same
conditions,
reverted
control
levels
increased
two
markers
ferroptosis,
form
recently
involved
pathogenesis
(TFRC
MDA:
13.4%
56.1%
respectively).
Conclusions.
These
results
suggest
could
inhibit
inflammation,
hyperproliferation
lesions,
be
considered
new
possible
strategy
for
further
evaluated
topic
vivo.
Язык: Английский
LncRNA TCONS_00067339 as a key regulatory factor inducing decreased cell viability and ferroptosis in neonatal hypoxic-ischemic brain damage
Brain Research,
Год журнала:
2025,
Номер
1854, С. 149562 - 149562
Опубликована: Март 8, 2025
Язык: Английский
Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 11, 2025
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death
driven
by
lipid
peroxidation,
plays
a
pivotal
role
in
various
physiological
and
pathological
processes.
In
this
review,
we
summarize
the
core
mechanisms
ferroptosis,
emphasizing
its
intricate
connections
to
metabolism,
including
fatty
acid
synthesis,
phospholipid
remodeling,
oxidation
dynamics.
We
further
highlight
advancements
detection
technologies,
such
as
fluorescence
imaging,
lipidomics,
vivo
PET
which
have
deepened
our
understanding
ferroptotic
regulation.
Additionally,
discuss
ferroptosis
human
diseases,
where
it
acts
double-edged
sword,
contributing
cancer
while
also
driving
ischemia-reperfusion
injury
neurodegeneration.
Finally,
explore
therapeutic
strategies
aimed
at
either
inducing
or
inhibiting
iron
chelation,
antioxidant
modulation,
lipid-targeted
interventions.
By
integrating
mechanistic
insights,
disease
relevance,
potential,
review
provides
comprehensive
perspective
on
crucial
interface
between
metabolism
oxidative
stress.
Язык: Английский
The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13334 - 13334
Опубликована: Дек. 12, 2024
Pancreatic
cancer
remains
one
of
the
most
lethal
forms
cancer.
Currently,
there
is
a
lack
effective
drug
treatments
for
pancreatic
However,
as
newly
discovered
form
non-apoptotic
cell
death,
ferroptosis
has
garnered
increasing
attention
in
relation
to
Understanding
role
tumorigenesis
and
treatment
may
enable
more
clinical
trials
minimize
side
effects
or
restrict
emergence
resistance.
In
this
review,
we
summarize
current
knowledge
regarding
process
underlying
mechanisms
ferroptosis,
well
its
dual
both
promoting
facilitating
strategies
Additionally,
how
implicated
development
pancreatitis
insulin
resistance,
indicating
that
play
an
important
risk
pancreatitis-
insulin-resistance-related
cancers,
also
addressed.
Язык: Английский
Sex and Gender Differences in Iron Chelation
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2885 - 2885
Опубликована: Дек. 18, 2024
Background/Objectives:
In
the
absence
of
physiological
mechanisms
to
excrete
excessive
iron,
administration
iron
chelation
therapy
is
necessary.
Age
and
hormones
have
an
impact
on
absorption,
distribution,
metabolism,
excretion
medications
used
treat
excess,
resulting
in
notable
sex-
gender-related
variances.
Methods:
Here,
we
aimed
review
literature
sex
gender
overload
assessment
treatment.
Results:
The
development
chelators
has
shown
be
a
successful
for
lowering
body’s
levels
averting
tissue
damage
organ
failure
that
follows.
Numerous
studies
described
how
individual
factors
can
treatment,
potentially
therapeutic
response,
and/or
result
inadequate
or
elevated
toxicity;
however,
most
these
data
not
considered
male
female
patients
as
different
groups,
particularly,
effect
hormonal
variations
women
never
been
considered.
Conclusions:
An
effective
treatment
should
take
into
account
differences.
Язык: Английский