Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

There has been abundant research on the variety of programmed cell death pathways. Apoptosis, pyroptosis, and necroptosis under action caspase family are essential for innate immune response. Caspases classified into inflammatory caspase-1/4/5/11, apoptotic caspase-3/6/7, caspase-2/8/9/10. Although is not caspase-dependent to transmit signals, it can cross-link with pyroptosis apoptosis signals regulation caspase-8. An increasing number studies have reiterated involvement in acute lung injuries caused by bacterial viral infections, blood transfusion, ventilation, which influenced noxious stimuli that activate or inhibit engagement pathways, leading subsequent injury. This article reviews role caspases implicated diverse mechanisms injury status relevant inhibitors against target proteins described mechanisms. The findings this review may help delineating novel therapeutic targets

Язык: Английский