Multi-modal data integration of dosiomics, radiomics, deep features, and clinical data for radiation-induced lung damage prediction in breast cancer patients
Journal of Radiation Research and Applied Sciences,
Год журнала:
2025,
Номер
18(2), С. 101389 - 101389
Опубликована: Март 3, 2025
Язык: Английский
A Feasibility Study of Liver Conformal Therapy Based on Minimally Invasive Steam Interventional Thermal Ablation: Design, Simulation, and Experimental Research
Опубликована: Янв. 1, 2025
Язык: Английский
Ionizing Radiation May Induce Tumors Partly Through the Alteration or Regulation of Mismatch Repair Genes
Cancers,
Год журнала:
2025,
Номер
17(4), С. 564 - 564
Опубликована: Фев. 7, 2025
Ionizing
radiation
is
mutagenic
and
carcinogenic,
it
reported
to
induce
primary
secondary
tumors
with
intestinal
being
one
of
the
most
commonly
observed.
However,
pathological
molecular
mechanism(s)
underlying
radiation-associated
tumorigenesis
remain
unclear.
A
link
between
somatic
partly
through
genetic,
epigenetic
alteration
and/or
regulation
mismatch
repair
(MMR)
genes
has
been
hypothesized
for
first
time
within
this
review.
Clinical
observations
experimental
findings
provide
significant
support
association
including
MMR
mutations
as
well
altered
RNA
protein
expressions
that
occurred
post-exposure,
although
existing
evidence
in
published
literature
sparse
niche
area.
Some
speculative
mechanisms
are
suggested
review
inform
future
research.
Further
studies
needed
understand
roles
system
response
test
possible
connection
which
could
potentially
useful
urgently
information
clinical
guidance.
Язык: Английский
A feasibility study of liver conformal therapy based on minimally invasive steam interventional thermal ablation: Design, simulation, and experimental research
International Communications in Heat and Mass Transfer,
Год журнала:
2025,
Номер
164, С. 108924 - 108924
Опубликована: Апрель 6, 2025
Язык: Английский
Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer Therapy
Radiation,
Год журнала:
2024,
Номер
4(4), С. 309 - 324
Опубликована: Окт. 24, 2024
Radiotherapy
remains
a
cornerstone
in
cancer
treatment,
leveraging
ionizing
radiation
to
eradicate
malignant
cells.
Its
efficacy,
however,
is
frequently
challenged
by
the
heterogeneous
sensitivity
of
tumors
and
surrounding
tissues
radiation.
Therefore,
understanding
molecular
mechanisms
underlying
radiosensitivity
crucial
for
improving
treatment
outcomes.
Among
myriad
players
involved,
tumor
suppressor
protein
p53
stands
out
as
central
regulator
with
significant
implications
radiosensitivity.
Known
“guardian
genome”,
plays
pivotal
role
maintaining
genomic
stability
orchestrating
cellular
responses
such
cell
cycle
arrest,
DNA
repair,
apoptosis,
senescence
response
various
stress
signals,
including
radiation-induced
damage.
Activation
triggers
transcription
target
genes
involved
repair
pathways,
p21,
MDM2,
GADD45,
facilitating
damage
or
elimination
irreparably
damaged
This,
turn,
influences
overall
tissues.
Mutations
TP53
gene,
which
encodes
p53,
are
among
most
frequent
genetic
alterations
human
cancers.
Loss
dysfunction
can
compromise
radiation,
leading
increased
resistance
therapy
poorer
clinical
Conversely,
intact
function
associated
enhanced
due
its
ability
promote
arrest
apoptosis
In
conclusion,
elucidating
essential
advancing
our
cells
developing
more
effective
therapeutic
approaches
treatment.
This
review
provides
comprehensive
overview
multifaceted
modulating
emphasizing
influence
on
Язык: Английский