Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer
Molecular Biomedicine,
Год журнала:
2025,
Номер
6(1)
Опубликована: Янв. 6, 2025
Cancer
remains
a
leading
cause
of
mortality
globally
and
major
health
burden,
with
chemotherapy
often
serving
as
the
primary
therapeutic
option
for
patients
advanced-stage
disease,
partially
compensating
limitations
non-curative
treatments.
However,
emergence
resistance
significantly
limits
its
efficacy,
posing
clinical
challenge.
Moreover,
heterogeneity
mechanisms
across
cancer
types
complicates
development
universally
effective
diagnostic
approaches.
Understanding
molecular
chemoresistance
identifying
strategies
to
overcome
it
are
current
research
focal
points.
This
review
provides
comprehensive
analysis
key
underlying
resistance,
including
drug
efflux,
enhanced
DNA
damage
repair
(DDR),
apoptosis
evasion,
epigenetic
modifications,
altered
intracellular
metabolism,
role
stem
cells
(CSCs).
We
also
examine
specific
causes
in
highlight
various
targets
involved
resistance.
Finally,
we
discuss
aiming
at
overcoming
such
combination
therapies,
targeted
treatments,
novel
delivery
systems,
while
proposing
future
directions
this
evolving
field.
By
addressing
these
barriers,
lays
foundation
more
therapies
aimed
mitigating
Язык: Английский
Genomische Instabilität als Rationale bei der Krebstherapie
Forum,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Targeting acquired resistance via promoting stemness of EGFR mutant mitigates lung adenocarcinomas progression: Intervention by harpagoside (Xuandanqingjin decoction)
Journal of Functional Foods,
Год журнала:
2025,
Номер
127, С. 106729 - 106729
Опубликована: Март 20, 2025
Язык: Английский
DNA Repair, Cancer and Cancer Therapy
InTech eBooks,
Год журнала:
2011,
Номер
unknown
Опубликована: Окт. 26, 2011
The
success
of
an
organism
to
survive
from
one
generation
the
next
is
largely
dependent
upon
fidelity
replication
its
genetic
material,
deoxyribonucleic
acid
(DNA).
Unfortunately,
DNA
in
living
cell
labile
and
subject
many
chemical
alterations,
these
if
not
corrected,
can
lead
diseases
such
as
cancer
(Fig.
1)
(Pallis
&
Karamouzis,
2010).
All
eukaryotic
cells
have
evolved
a
multifaceted
response
counteract
potentially
deleterious
effects
damage
2).
Upon
sensing
damage,
cycle
checkpoints
are
activated
arrest
progression
allow
time
for
repair
before
passed
on
cells.
Depending
type
other
cellular
mechanisms
transcriptional
program
activation,
pathways,
apoptosis
also
be
induced.
processes
coordinated
so
material
faithfully
maintained,
duplicated,
segregated
within
cell.
Important
goals
research
determine
molecular
that
involved
formation
changes
human
genes
consequence
mutations
explain
how
withstand
by
use
different
defense
ranging
free
radical
scavengers
sophisticated
mechanisms.
Язык: Английский