Spatiotemporally-specific cortical-subthalamic coupling differentiates aspects of speech performance DOI Creative Commons
Matteo Vissani, Alan Bush, Witold Lipski

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 19, 2023

Speech provides a rich context for understanding how cortical interactions with the basal ganglia contribute to unique human behaviors, but opportunities direct intracranial recordings across cortical-basal networks are rare. We recorded electrocorticographic signals in cortex synchronously single units during awake neurosurgeries where subjects spoke syllable repetitions. discovered that individual STN neurons have transient (200ms) spike-phase coupling (SPC) events multiple regions. The spike timing of was coordinated phase theta-alpha oscillations posterior supramarginal and superior temporal gyrus speech planning production. sound errors occurred when this STN-cortical interaction delayed. Our results suggest supports mechanisms auditory-sensorimotor integration production required achieve high fidelity phonological articulatory representation target phoneme. These findings establish framework other additionally indicate firing-rate based models insufficient explaining circuit behavior.

Язык: Английский

Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy DOI Creative Commons
Elena Bernasconi, Deborah Amstutz, Alberto Averna

и другие.

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 3, 2025

Abstract Sensing-based deep brain stimulation should optimally consider both the motor and neuropsychiatric domain to maximize quality of life Parkinson’s disease (PD) patients. Here we characterize neurophysiological properties subthalamic nucleus (STN) in 69 PD patients using a newly established gradient metric contextualize it with symptoms apathy. We could evidence STN power that holds most spectral information between 5 30 Hz spanning along dorsal-ventral axis. It shows elevated sub-beta range (8-12 Hz) toward ventral STN, dorsal beta (16–24 indicative for hemispheres contralateral more affected hemi-body side. The rigidity response DBS was highest dorsally on Importantly, apathetic can be related reduced alpha power. In conclusion, may inform about domain, supporting integrative closed-loop strategies.

Язык: Английский

Процитировано

1
Local Field Potentials Predict Motor Performance in Deep Brain Stimulation for Parkinson's Disease DOI Creative Commons
Johannes L. Busch,

Jonathan Kaplan,

Bahne H. Bahners

и другие.

Movement Disorders, Год журнала: 2023, Номер 38(12), С. 2185 - 2196

Опубликована: Окт. 12, 2023

Abstract Background Deep brain stimulation ( DBS ) is an effective treatment option for patients with Parkinson's disease PD ). However, clinical programming remains challenging segmented electrodes. Objective Using novel sensing‐enabled neurostimulators, we investigated local field potentials LFPs and their modulation by to assess whether electrophysiological biomarkers may facilitate in chronically implanted patients. Methods Sixteen (31 hemispheres) electrodes the subthalamic nucleus a neurostimulator were included this study. Recordings conducted 3 months after surgery following overnight withdrawal of dopaminergic medication. acquired while was turned OFF during monopolar review both directional ring contacts. Directional beta power stimulation‐induced suppression computed. Motor performance, as assessed pronation‐supination task, electrode placement correlated suppression. Results Better motor performance associated stronger at higher amplitudes. Across contacts, differences extent predicted performance. within individual hemispheres, superior selecting contact best Contacts clinically activated chronic than non‐activated Conclusions Our results suggest that β most contact. In sum, guide systems © 2023 The Authors. Movement Disorders published Wiley Periodicals LLC on behalf International Parkinson Disorder Society.

Язык: Английский

Процитировано

12
Disentangling Bradykinesia and Rigidity in Parkinson's Disease: Evidence from Short‐ and Long‐Term Subthalamic Nucleus Deep Brain Stimulation DOI Creative Commons
Alessandro Zampogna, Antonio Suppa, Francesco Bove

и другие.

Annals of Neurology, Год журнала: 2024, Номер 96(2), С. 234 - 246

Опубликована: Май 9, 2024

Objective Bradykinesia and rigidity are considered closely related motor signs in Parkinson disease (PD), but recent neurophysiological findings suggest distinct pathophysiological mechanisms. This study aims to examine compare longitudinal changes bradykinesia PD patients treated with bilateral subthalamic nucleus deep brain stimulation (STN‐DBS). Methods In this retrospective cohort study, the clinical progression of appendicular axial was assessed up 15 years after STN‐DBS best treatment conditions (ON medication ON stimulation). The severity examined using ad hoc composite scores from specific subitems Unified Parkinson's Disease Rating Scale part (UPDRS‐III). Short‐ long‐term predictors were analyzed through linear regression analysis, considering various preoperative demographic data, including duration severity, phenotype, cognitive (eg, frontal score), medication. Results A total 301 before 1 year surgery. Among them, 101 56 individuals also evaluated at 10‐year 15‐year follow‐ups, respectively. significantly worsened surgery, especially segments ( p < 0.001). Conversely, showed sustained benefit, unchanged compared assessment > 0.05). Preoperative disability UPDRS‐III) predicted short‐ outcomes for both 0.01). Executive dysfunction specifically linked not Interpretation show divergent following associated independent factors, supporting hypothesis partially pathophysiology. ANN NEUROL 2024;96:234–246

Язык: Английский

Процитировано

4
Machine learning explains response variability of deep brain stimulation on Parkinson’s disease quality of life DOI Creative Commons
Enrico Ferrea, Farzin Negahbani, Idil Cebi

и другие.

npj Digital Medicine, Год журнала: 2024, Номер 7(1)

Опубликована: Окт. 2, 2024

Abstract Improving health-related quality of life (QoL) is crucial for managing Parkinson’s disease. However, QoL outcomes after deep brain stimulation (DBS) the subthalamic nucleus (STN) vary considerably. Current approaches lack integration demographic, patient-reported, neuroimaging, and neurophysiological data to understand this variability. This study used explainable machine learning analyze multimodal factors affecting changes, measured by Disease Questionnaire (PDQ-39) in 63 patients, quantified each variable’s contribution. Results showed that preoperative PDQ-39 scores upper beta band activity (>20 Hz) left STN were key predictors changes. Lower initial burden predicted worsening, while improvement was associated with higher activity. Additionally, electrode positions along superior-inferior axis, especially relative z = −7 coordinate standard space, influenced outcomes, improved worsened above below marker. emphasizes a tailored, data-informed approach optimize DBS treatment improve patient QoL.

Язык: Английский

Процитировано

4
A deep learning-based model for automated STN localization using local field potentials in Parkinson’s disease DOI
Mohamed Hosny, M. Asif Naeem, Minwei Zhu

и другие.

Soft Computing, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain‐Sense Study DOI Creative Commons
Aaron Colombo,

Elena Bernasconi,

Laura Alva

и другие.

Movement Disorders, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Abstract Background Novel commercial brain‐sense neurostimulators enable us to contextualize brain activity with symptom and medication states in real‐life ambulatory settings Parkinson's disease (PD). Although various candidate biomarkers have been proposed for adaptive deep stimulation (DBS), a comprehensive comparison of their profiles is lacking. Objectives To systematically compare the neurophysiological dynamics clinical properties three biomarkers—low‐frequency, beta (β), finely tuned γ (FTG) activity. Methods We investigated 14 PD patients implanted Medtronic Percept PC, who underwent up two 4‐week multimodal recording periods on regular stimulation. Subthalamic nucleus local field potentials (LFPs) low‐frequency, β, FTG were recorded. Additionally, objective motor states, physical heart rate using wearables, as well medication‐intake times, sleep‐awake subjective diaries co‐registered. LFP also compared high‐resolution in‐hospital recordings under off / dopaminergic conditions. Results reliably indexed setting at group individual levels, these spectral could be anticipated by recordings. Both low‐frequency correlated wearable‐based dyskinesia scores, whereas diary‐based events only linked FTG. Importantly, indicated ‐medication regardless presence despite potential motion artifacts. The 24‐hour profile revealed large circadian power shifts that may overdrive dynamics. Conclusion Despite limitations low‐temporal resolution recordings, this work provides valuable insights into biomarkers. Specifically, it highlights utility primary reliable indicator DBS. © 2025 Author(s). Movement Disorders published Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Язык: Английский

Процитировано

0
Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy DOI Creative Commons
Matteo Vissani, Alan Bush, Witold Lipski

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 9, 2025

Speech provides a rich context for understanding how cortical interactions with the basal ganglia contribute to unique human behaviors, but opportunities direct intracranial recordings across cortical-basal networks are rare. Here we have recorded electrocorticographic signals in cortex synchronously single units during awake neurosurgeries where participants spoke syllable repetitions. We discovered that individual subthalamic nucleus (STN) neurons transient (200 ms) spike-phase coupling (SPC) events multiple regions. The spike timing of STN is locked phase theta-alpha oscillations supramarginal and posterior superior temporal gyrus speech planning production. sound errors occur when this STN-cortical interaction delayed. Our results suggest timely between perisylvian support auditory-motor coordinate transformation or phonological working memory planning. These findings establish framework other additionally indicate firing-rate based models insufficient explaining circuit behavior.

Язык: Английский

Процитировано

0
Subthalamic Beta Power and Gait in Parkinson’s Disease During Unsupervised Remote Monitoring DOI Creative Commons
Massimo Marano, Gerd Tinkhauser,

Gaia Anzini

и другие.

Parkinsonism & Related Disorders, Год журнала: 2025, Номер unknown, С. 107903 - 107903

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
Should asleep deep brain stimulation in Parkinson’s disease be preferred over the awake approach? – Pros DOI Creative Commons
Gerd Tinkhauser,

Claudio Pollo,

Ines Debove

и другие.

Schweizerische medizinische Wochenschrift, Год журнала: 2024, Номер 154(8), С. 3823 - 3823

Опубликована: Авг. 9, 2024

No abstract available.

Процитировано

1
Validation of Lead-DBS β-oscillation Localization with Directional Electrodes DOI Open Access
Colette Boëx, Abdullah Al Awadhi,

Rémi Tyrand

и другие.

Опубликована: Июнь 23, 2023

The Lead-DBS imaging toolbox reconstructs the location of &beta;-oscillations in subthalamic nucleus (STN) patients with Parkinson&rsquo;s disease. objective was to compare this probabilistic those intraoperative monopolar (Vercise Cartesia directional electrodes, Boston Scientific). Also, efficacy stimulated structures reducing motor symptoms were analysed. computed from local field potentials [0.5-3kHz] by using shielded wires for recordings an extracranial reference. For each electrode contact, power spectral densities &beta;-band [13-31Hz] compared all eight contacts. DISTAL, electrophysiological, and DBS target atlases applied reconstructed electrodes preoperative MRI postoperative CT. Thirty-six (20 patients: 7 female, 13 male; 16/20 both, 4/20 single STN) Stimulation sites dorsal and/or lateral sensorimotor STN most efficient. In 33/36 at least one contact measured stronger &beta;-oscillations, 23 or touching ventral subpart volume 10 not located but adjacent volume; 3/36 no found they distant volume. Monopolar confirmed &beta;-oscillations.

Язык: Английский

Процитировано

1