bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 19, 2023
Speech
provides
a
rich
context
for
understanding
how
cortical
interactions
with
the
basal
ganglia
contribute
to
unique
human
behaviors,
but
opportunities
direct
intracranial
recordings
across
cortical-basal
networks
are
rare.
We
recorded
electrocorticographic
signals
in
cortex
synchronously
single
units
during
awake
neurosurgeries
where
subjects
spoke
syllable
repetitions.
discovered
that
individual
STN
neurons
have
transient
(200ms)
spike-phase
coupling
(SPC)
events
multiple
regions.
The
spike
timing
of
was
coordinated
phase
theta-alpha
oscillations
posterior
supramarginal
and
superior
temporal
gyrus
speech
planning
production.
sound
errors
occurred
when
this
STN-cortical
interaction
delayed.
Our
results
suggest
supports
mechanisms
auditory-sensorimotor
integration
production
required
achieve
high
fidelity
phonological
articulatory
representation
target
phoneme.
These
findings
establish
framework
other
additionally
indicate
firing-rate
based
models
insufficient
explaining
circuit
behavior.
Neurodegenerative Disease Management,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Сен. 30, 2024
Deep
brain
stimulation
(DBS)
has
been
established
as
an
effective
neuromodulatory
treatment
for
Parkinson's
disease
(PD)
with
motor
complications
or
refractory
tremor.
Various
DBS
devices
unique
technology
platforms
are
commercially
available
and
deliver
continuous,
open-loop
stimulation.
The
Percept™
family
of
neurostimulators
use
BrainSense™
five
key
features
to
sense
local
field
potentials
while
stimulating,
enabling
integration
physiologic
data
into
the
routine
practice
programming.
newly
approved
rechargeable
RC
implantable
pulse
generator
offers
a
smaller,
thinner
design
reduced
recharge
time
prolonged
interval.
In
this
review,
we
describe
application
potential
sensing-based
programming
in
PD
highlight
future
clinical
implementation
closed-loop
using
generator.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 19, 2023
Speech
provides
a
rich
context
for
understanding
how
cortical
interactions
with
the
basal
ganglia
contribute
to
unique
human
behaviors,
but
opportunities
direct
intracranial
recordings
across
cortical-basal
networks
are
rare.
We
recorded
electrocorticographic
signals
in
cortex
synchronously
single
units
during
awake
neurosurgeries
where
subjects
spoke
syllable
repetitions.
discovered
that
individual
STN
neurons
have
transient
(200ms)
spike-phase
coupling
(SPC)
events
multiple
regions.
The
spike
timing
of
was
coordinated
phase
theta-alpha
oscillations
posterior
supramarginal
and
superior
temporal
gyrus
speech
planning
production.
sound
errors
occurred
when
this
STN-cortical
interaction
delayed.
Our
results
suggest
supports
mechanisms
auditory-sensorimotor
integration
production
required
achieve
high
fidelity
phonological
articulatory
representation
target
phoneme.
These
findings
establish
framework
other
additionally
indicate
firing-rate
based
models
insufficient
explaining
circuit
behavior.
