Journal of Clinical Neuroscience, Год журнала: 2024, Номер 133, С. 111016 - 111016
Опубликована: Дек. 28, 2024
Язык: Английский
Nature Reviews Neurology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Окт. 9, 2024
This systematic review aims to comprehensively analyze the efficacy and underlying mechanisms of vagus nerve stimulation (VNS) in enhancing cognitive functions its therapeutic potential for various impairments. The focuses on impact VNS emotional processing, executive functions, learning, memory, clinical applications conditions such as epilepsy, depression, Alzheimer's disease, other neurological disorders.
Язык: Английский
Процитировано
5
Current Opinion in Neurology, Год журнала: 2024, Номер 37(4), С. 394 - 399
Опубликована: Июнь 3, 2024
Purpose of review The primary aim this is to describe and update the pathophysiological relevant therapeutic strategies for freezing gait (FoG) in patients with Parkinson's disease (PD). Recent findings FoG presumably involves dysfunction multiple cortical subcortical components, including dopaminergic nondopaminergic circuits. In regard, levodopa physical therapy represent first-choice options PD FoG. However, relationship between not fully predictable. For those levodopa-resistant FoG, there promising but still controversial data on benefits bilateral high-frequency transcranial magnetic stimulation deep brain subthalamic nuclei, substantia nigra pars reticulata, pedunculopontine nucleus, Fields Forel. On other hand, general exercise, training a treadmill, focus attention training, conventional physiotherapy have demonstrated moderate large Summary FOG requires different treatment strategies. inclusion adequate detection prediction combined double-blind, statistically powered protocols are needed improve patients’ quality life, motor nonmotor symptoms societal burden associated
Язык: Английский
Процитировано
3
Movement Disorders Clinical Practice, Год журнала: 2024, Номер 11(8), С. 927 - 947
Опубликована: Июнь 20, 2024
Parkinson's Disease (PD) is a progressive neurological disorder that results in potentially debilitating mobility deficits. Recently, spinal cord stimulation (SCS) has been proposed as novel therapy for PD gait disorders. The highest levels of evidence remain limited SCS.
Язык: Английский
Процитировано
3
Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 16
Опубликована: Янв. 14, 2025
Transcutaneous vagus nerve stimulation (tVNS) has emerged as a novel noninvasive adjunct therapy for advanced Parkinson's disease (PD), yet no quantitative analysis had been conducted to assess its therapeutic effect. This review aimed investigate the efficacy of tVNS on motor function, other potential clinical targets and safety in various treatment conditions. We searched six databases randomized controlled trials (RCTs) that involved treating PD patients with tVNS. Primary outcome was functions, including severity signs, functional mobility balance, gait parameters. Secondary outcomes were cognition, emotion, sleep related impairments, patient reported non-motor outcomes, any adverse events. All classified analyzed according duration medication condition an included study. Risk bias evaluated by referencing Cochrane risk tool 1.0. Data Revman 5.4. 6 RCTs 176 included. Several functions measured during on-medication (severity signs -0.48 [95% CI -0.93, -0.04], -0.85, -0.1], -0.4 -0.78, -0.03]), improved significantly. However, verbal fluency, sleep-related impairment, fatigue negatively impacted condition. No distinct events reported. is relatively safe PD. It small moderate effects may impact few outcomes. Quality level evidence low further research warranted. https://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD42024503322 (PROSPERO).
Язык: Английский
Процитировано
0
npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)
Опубликована: Март 1, 2025
Our study aimed to investigate the neural mechanisms of taVNS in motor symptoms PD, focusing on topological properties cortical functional networks and excitability. Thirty-two PD patients underwent near‐infrared spectroscopy transcranial magnetic stimulation evaluation prior after two-week taVNS, which were controlled by 20 healthy controls (HCs). exhibited decreased nodal efficiency (Ne) right M1 increased Ne left pre‐motor supplementary area compared with HCs. The was negatively associated UPDRS-III scores. Interestingly, treatment improved increasing enhancing intracortical facilitation (ICF, ISI 10, 15 ms). ICF (ISI ms) correlated could improve information processing enhance disorders.
Язык: Английский
Процитировано
0
Neuromodulation Technology at the Neural Interface, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Март 28, 2025
Post-Traumatic Stress Disorder (PTSD) is a condition marked by chronic autonomic dysregulation, including heightened arousal and increased heart rate, contributing to higher risk of cardiovascular disease (CVD). tcVNS has been shown in prior work decrease reduce rate participants with PTSD during stimulation 2-3 min afterward. No studies have investigated effects on objective physiological markers such as over hour-long timescales. The purpose this study was investigate the active versus sham responses stress traumatized individuals without undergoing 3 h traumatic reminder protocol. Understanding extended periods lasting several hours crucial better assess its potential benefits inform treatment strategies for population. A total 41 participants, 22 (sex: 16 female, six male; age: 41.5 ± 12.89 years) 19 nine 10 32.79 7.10 years), participated mechanistic clinical trial that elicited trauma-incited replaying recorded scripts followed or (double-blind, randomized). Continuous electrocardiogram data were collected used measure temporal alignment resampling beat-by-beat time series performed distinctively enable timepoint averaging entire research visit. We then aggregated across same group (active/sham × PTSD/non-PTSD) multi-hour Analysis revealed accrued reductions among who received compared those (P < 0.05). These not observed non-PTSD participants. Notably, reduced approximately 5% below baseline levels end ∼3 h-long protocol, indicating cardiac function. induces PTSD, potentially suggesting temporary reduction associated PTSD.
Язык: Английский
Процитировано
0
Perspectives of the ASHA Special Interest Groups, Год журнала: 2025, Номер unknown, С. 1 - 13
Опубликована: Май 23, 2025
Purpose: Chronic dizziness and imbalance is often difficult to rehabilitate based on the complex set of systems involved. Recently, transcutaneous vagus nerve stimulation (tVNS) has been investigated as a noninvasive means reduce symptoms associated with vestibular impairment, chronic dizziness, neurological conditions affecting balance control. The purpose this integrative review examine available data describing therapeutic efficacy proposed mechanisms tVNS in adult patients imbalance. Method: PubMed, Europe PMC, Google Scholar searches were conducted using following search terms from 1987 2024: “vagal stimulat*” OR “vagus “transcutaneous “tVNS” AND “dizziness,” “vertigo.” Articles imported for screening through Rayyan. discussing use study metrics related function humans selected full-text review. Results: Eleven articles identified meeting inclusion criteria are classified according neurotological class studied level evidence provided. Available show that may benefit subjective including quality life reduction handicap. Less-controlled case suggests additional manifest changes vestibulo-ocular reflex function. Conclusion: Although exposure provided variable degrees both (e.g., life) objective gait) contexts, degree which distinct can explain these benefits unclear.
Язык: Английский
Процитировано
0
Movement Disorders, Год журнала: 2024, Номер 39(8), С. 1375 - 1385
Опубликована: Май 17, 2024
Abstract Background Transcutaneous electrostimulation of the auricular branch vagal nerve (taVNS) has propensity to reach diffuse neuromodulatory networks, which are dysfunctional in Parkinson's disease (PD). Previous studies support use taVNS as an add‐on treatment for gait PD. Objectives We assessed effect at 25 Hz (taVNS25), 100 (taVNS100), and sham earlobe stimulation (sVNS) on levodopa responsive (arm swing velocity, arm range motion, stride length, speed) non‐responsive characteristics motion asymmetry, anticipatory postural adjustment [APA] duration, APA first step motion), turns (first turn double 360° steps per turn) advanced Methods In our blind controlled within‐subject randomized trial, we included 30 PD patients (modified Hoehn Yahr stage, 2.5–4) assess taVNS25, taVNS100, sVNS measured with inertial sensors during instrumented stand walk test a turn. Separate generalized mixed models were built each characteristic. Results During taVNS100 compared velocity ( P = 0.030) length increased 0.027), duration decreased 0.050). taVNS25 0.024) speed 0.021) 0.039). Conclusions have found that frequency specific improve patients. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC behalf International Parkinson Disorder Society.
Язык: Английский
Процитировано
2