Expert Review of Medical Devices, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Magnetic resonance-guided focused ultrasound (MRgFUS) has emerged as a leading noninvasive therapy for tremor, offering precise, lesion-based alternative to deep brain stimulation (DBS) and traditional lesioning techniques. By using phased arrays focus energy at intracranial targets, MRgFUS allows real-time visualization monitoring, improving safety efficacy. Initially developed essential tremor (ET), MRgFUS-VIM-thalamotomy gained widespread acceptance is now first-line option tremor-dominant Parkinson's disease (TDPD) other syndromes. This review discusses the fundamental physics of ultrasound, key anatomical clinical application thalamotomy, pallidotomy, subthalamotomy. Skull density ratio (SDR) efficiency are highlighted crucial factors affecting treatment outcomes. The evolution bilateral treatment, along with exploration novel targets such pallidothalamic tract, examined. Additionally, we discuss advancements in FUS neuromodulation, which could complement by providing temporary or reversible symptom relief. poised further revolutionize frameless technology, staged procedures, integration neuromodulation. Future developments may allow adaptive therapies that enhance both efficacy patient experience.
Язык: Английский