Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain DOI Creative Commons
Juliana Choza, Mahek Virani,

Nathan C. Kuhn

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 22, 2024

Abstract Epigenetic mechanisms are mediators of interactions between aging, genetics, and environmental factors in sporadic Parkinson’s disease (PD). Multiple studies have explored the DNA modifications PD, but few focus on 5-hydroxymethylcytosine (5-hmC), which is important central nervous system sensitive to exposures. To date, not differentiated 5-methylcytosine (5-mC) 5-hmC or analyzed them separately. In this study, we modeled paired 5-mC data simultaneously. We identified 108 cytosines with significant PD-associated shifts these marks an enriched neuronal population from PD postmortem parietal cortex, within 83 genes 34 enhancers associated 67 genes. These potentially link epigenetic regulation related LRRK2 endolysosomal sort ( RAB32 AGAP1 ), involved neuroinflammation, inflammasome, neurodevelopment early changes suggest that there 5mC 5hmC captured by standard methods.

Язык: Английский

Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain DOI Creative Commons
Juliana Choza, Mahek Virani,

Nathan C. Kuhn

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 22, 2024

Abstract Epigenetic mechanisms are mediators of interactions between aging, genetics, and environmental factors in sporadic Parkinson’s disease (PD). Multiple studies have explored the DNA modifications PD, but few focus on 5-hydroxymethylcytosine (5-hmC), which is important central nervous system sensitive to exposures. To date, not differentiated 5-methylcytosine (5-mC) 5-hmC or analyzed them separately. In this study, we modeled paired 5-mC data simultaneously. We identified 108 cytosines with significant PD-associated shifts these marks an enriched neuronal population from PD postmortem parietal cortex, within 83 genes 34 enhancers associated 67 genes. These potentially link epigenetic regulation related LRRK2 endolysosomal sort ( RAB32 AGAP1 ), involved neuroinflammation, inflammasome, neurodevelopment early changes suggest that there 5mC 5hmC captured by standard methods.

Язык: Английский

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