International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139094 - 139094
Опубликована: Дек. 1, 2024
Язык: Английский
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189175 - 189175
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
19
Nanomaterials, Год журнала: 2024, Номер 14(7), С. 648 - 648
Опубликована: Апрель 8, 2024
Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.
Язык: Английский
Процитировано
7
Опубликована: Авг. 20, 2024
Reactive oxygen species (ROS) are produced during cellular metabolism and in response to environmental stress. While low levels of ROS play essential physiological roles, excess can damage components, leading cell death or transformation. also regulate protein interactions cancer cells, thereby affecting processes such as growth, migration, angiogenesis. Dysregulated occur via various mechanisms, including amino acid modifications, conformational changes, alterations complex stability. Understanding ROS-mediated changes is crucial for targeted therapies. In this review, we examine the role that mechanisms regulating pathways through protein-protein interactions.
Язык: Английский
Процитировано
4
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 29, 2025
Abstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies immunotherapies is commonly compromised by emergence drug resistance other factors, resulting in lack durable therapeutic benefits. Ferroptosis, distinct pattern cell death marked buildup iron-dependent lipid peroxides, has been shown to be novel potentially more effective treatment for lung carcinoma. However, mechanism regulatory network ferroptosis are exceptionally complex, many unanswered questions remain. In addition, research diagnosis cancer growing exponentially. Therefore, it necessary provide thorough summary latest advancements field ferroptosis. Here, we comprehensively analyze mechanisms underlying preconditions ferroptosis, defense system, associated molecular networks. potential strategies also highlighted. Targeting improves tumor enhances effectiveness drugs immunotherapies. These findings may shed fresh light management carcinoma, as well development related
Язык: Английский
Процитировано
0
Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116913 - 116913
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(13), С. e34046 - e34046
Опубликована: Июль 1, 2024
BackgroundThe tumor microenvironment (TME) typically experiences oxidative stress (OS), marked by a high level of reactive oxygen species (ROS) that can impact advancement and prognosis modulating the behavior cells various immune cells. Oxidative stress-related genes (OSRG) encompass range involved in ROS pathways, their specific roles breast cancer (BC) necessitate further investigation.MethodsUnivariate Cox analysis was performed on linked to OS pathway Gene Set Enrichment Analysis (GSEA) database, leading identification 29 significant OSRG BC. divided into three distinct clusters according expression score based differentially expressed (DEGs) calculated principal component (PCA). The correlation between BC clinical features, mutation characteristics, checkpoints cell infiltration analyzed. Establish multiariable regression model predict effects characteristics.ResultsSignificant differences were observed survival analysis, enriched among genes. identified through final selected 395 DEGs, revealing patterns. An constructed using demonstrating association poor prognosis. Significantly, checkpoint-related exhibited notable upregulation cohort. Additionally, positive burden (TMB) holds potential implications for immunotherapy patients, nomogram with robust predictive capability evaluating patient prognosis.ConclusionsThis study elucidated features within TME possible prognostic significance, offering valuable insights development more targeted approaches individuals
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9255 - 9255
Опубликована: Авг. 27, 2024
Reactive oxygen species (ROS) are produced during cellular metabolism and in response to environmental stress. While low levels of ROS play essential physiological roles, excess can damage components, leading cell death or transformation. also regulate protein interactions cancer cells, thereby affecting processes such as growth, migration, angiogenesis. Dysregulated occur via various mechanisms, including amino acid modifications, conformational changes, alterations complex stability. Understanding ROS-mediated changes is crucial for targeted therapies. In this review, we examine the role that mechanisms regulating pathways through protein–protein interactions.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 4, 2024
Abstract Pyroptosis, an inflammatory cell death, has attracted great attention for potentiating a strong immune response against tumor cells. However, developing powerful pyroptosis inducers and then activating specific still remains challenging. Herein, PEG‐CuP‐COF@∆St nanosystem is rationally designed, consisting of PEG‐CuP‐COF nanozyme tumor‐targeting bacteria the Salmonella Typhimurium strain VNP20009 (ΔSt), with affinity hypoxic microenvironment. The nanozymes possessed excellent sonodynamic performance multienzyme‐mimicking activities to generate reactive oxygen species (ROS) induce potent pyroptosis. superoxide dismutase‐ peroxidase‐mimicking catalytically produced hydrogen peroxide (H 2 O ) hydroxyl radicals (•OH) which have important value in triggering acute responses Moreover, showed outstanding glutathione activities, impairing antioxidant defense cells enhancing efficiency by making them more vulnerable ROS‐induced damage. During vivo studies, its self‐driven property exhibited impressive capability activated Caspase‐3/gasdermin E‐dependent inhibit growth. More importantly, it induced memory effect prevent bone metastasis. In summary, this study introduces innovative approach combinatorial sono‐catalytic immunotherapy using bacteria‐mediated delivery as inducers.
Язык: Английский
Процитировано
1
Cell Reports Physical Science, Год журнала: 2024, Номер 5(7), С. 102074 - 102074
Опубликована: Июль 1, 2024
Clinical practices have shown that Streptococcus pneumoniae (S. pn) can induce severe lung injury by secreting amounts of hydrogen peroxide (H2O2). Inspired the reactive oxygen species (ROS)-mediated host-damaging characteristics S. pn, we intended to apply pn for tumor therapy considering heightened susceptibility cells oxidative damage. However, antitumor efficacy was not ideal due constrained oxidizing capacity H2O2. To further improve anti-tumor effect, developed a biohybrid system (BHS) equip with ferroferric oxide (Fe3O4) artificial enzymes via click chemistry in situ, facilitating conversion bacteria-derived H2O2 into highly active hydroxyl radicals (⋅OH) enhanced radical even hypoxic pancreatic model. The situ-formed pn-based opens up an avenue treatment malignant tumors utilizing inherent tissue damage characteristic pathogens.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139094 - 139094
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0