International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12990 - 12990
Опубликована: Дек. 3, 2024
Head
and
neck
cancer
(HNC)
represents
a
challenging
oncological
entity
with
significant
morbidity
mortality
rates.
Despite
advances
in
conventional
therapies,
including
surgery,
chemotherapy,
radiation
therapy,
the
overall
survival
rates
for
advanced
HNC
remain
suboptimal.
In
recent
years,
emerging
field
of
oncolytic
virotherapy
has
gained
attention
as
promising
therapeutic
approach
various
malignancies,
HNC.
This
review
provides
comprehensive
overview
current
understanding
viruses
(Ovs)
context
treatment,
their
mechanisms
action,
preclinical
clinical
studies,
challenges,
future
directions.
Future
focuses
on
improving
delivery
specificity
through
nanoparticle
carriers
genetic
modifications
to
enhance
tumor
targeting
immune
response.
Combining
different
OVs
integrating
them
immunotherapies,
such
checkpoint
inhibitors,
could
overcome
resistance
improve
outcomes.
Personalized
approaches
rigorous
trials
are
key
ensuring
safety
effectiveness
treating
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 11, 2024
Abstract
As
one
of
the
significant
challenges
to
human
health,
cancer
has
long
been
a
focal
point
in
medical
treatment.
With
ongoing
advancements
field
medicine,
numerous
methodologies
for
therapy
have
emerged,
among
which
oncolytic
virus
gained
considerable
attention.
However,
viruses
still
exhibit
limitations.
Combining
them
with
various
therapies
can
further
enhance
efficacy
treatment,
offering
renewed
hope
patients.
In
recent
research,
scientists
recognized
promising
prospect
amalgamating
diverse
treatments,
potentially
surmounting
restrictions
singular
approaches.
The
central
concept
this
combined
revolves
around
leveraging
incite
localized
tumor
inflammation,
augmenting
immune
response
immunotherapeutic
efficacy.
Through
approach,
patient's
system
better
recognize
and
eliminate
cells,
simultaneously
reducing
evasion
mechanisms
against
system.
This
review
delves
deeply
into
latest
research
progress
concerning
integration
treatments
its
role
types
therapy.
We
aim
analyze
mechanisms,
advantages,
potential
challenges,
future
directions
combination
By
extensively
exploring
field,
we
instill
fight
cancer.
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 734 - 734
Опубликована: Июнь 21, 2024
Mesenchymal
stem/stromal
cells
(MSCs)
are
one
of
the
most
widely
used
cell
types
in
advanced
therapies
due
to
their
therapeutic
potential
regulation
tissue
repair
and
homeostasis,
immune
modulation.
However,
use
cancer
therapy
is
controversial:
they
can
inhibit
proliferation,
but
also
potentially
promote
tumour
growth
by
supporting
angiogenesis,
modulation
milieu
increasing
stem
invasiveness.
This
opposite
behaviour
highlights
need
for
careful
nuanced
MSCs
treatment.
To
optimize
anti-cancer
effects,
diverse
strategies
have
bioengineered
enhance
targeting
properties
or
deliver
drugs.
In
this
review,
we
highlight
uses
therapy,
particularly
as
carriers
targeted
treatments
natural
tumour-homing
capabilities.
We
discuss
MSC-derived
extracellular
vesicles
improve
efficiency
drug
molecule
delivery
cells.
Ongoing
clinical
trials
evaluating
these
setting
stage
future
advances
MSC-based
It
critical
identify
broad
potent
applications
solid
agent
position
them
effective
therapeutics
evolving
field
therapy.
Abstract
Mesenchymal
stem
cells
(MSCs)
are
recruited
by
malignant
tumor
to
the
microenvironment
(TME)
and
play
a
crucial
role
in
initiation
progression
of
tumors.
This
encompasses
immune
evasion,
promotion
angiogenesis,
stimulation
cancer
cell
proliferation,
correlation
with
cells,
multilineage
differentiation
within
TME,
development
treatment
resistance.
Simultaneously,
extensive
research
is
exploring
homing
effect
MSCs
MSC‐derived
extracellular
vesicles
(MSCs‐EVs)
tumors,
aiming
design
them
as
carriers
for
antitumor
substances.
These
substances
targeted
deliver
drugs
enhance
drug
efficacy
while
reducing
toxicity.
paper
provides
review
supportive
associated
molecular
mechanisms.
Additionally,
we
summarize
latest
therapeutic
strategies
involving
engineered
MSCs‐EVs
treatment,
including
their
utilization
gene
agents,
chemotherapeutics,
oncolytic
viruses.
We
also
discuss
distribution
clearance
upon
entry
into
body
elucidate
potential
therapies
based
on
along
challenges
they
face.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Июль 10, 2024
Oncolytic
viruses
(OVs)
have
emerged
as
a
potential
strategy
for
tumor
treatment
due
to
their
ability
selectively
replicate
in
cells,
induce
apoptosis,
and
stimulate
immune
responses.
However,
the
therapeutic
efficacy
of
single
OVs
is
limited
by
complexity
immunosuppressive
nature
microenvironment
(TME).
To
overcome
these
challenges,
engineering
has
become
an
important
research
direction.
This
review
focuses
on
methods
multi-modal
combination
therapies
aimed
at
addressing
delivery
barriers,
viral
phagocytosis,
antiviral
immunity
therapy.
The
approaches
discussed
include
enhancing
vivo
response,
improving
replication
efficiency
within
safety
profiles,
targeting
capabilities.
In
addition,
this
describes
mechanisms
combined
with
radiotherapy,
chemotherapy,
cell
therapy
checkpoint
inhibitors
(ICIs),
summarizes
data
ongoing
clinical
trials.
By
continuously
optimizing
strategies
programs,
we
can
achieve
improved
outcomes
quality
life
cancer
patients.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(11), С. 12672 - 12693
Опубликована: Ноя. 8, 2024
Mesenchymal
stem
cells
are
used
most
in
regenerative
medicine
due
to
their
capacities
differentiation
and
immune
modulation.
The
intraosseous
injection
of
MSC
into
the
bone
has
been
recommended
because
expected
outcomes
for
retention,
bioavailability,
enhanced
therapeutic
efficacy,
particularly
conditions
involving
bone,
such
as
osteoporosis
osteonecrosis.
A
review
delivery
mesenchymal
comparison
with
intravenous
intra-arterial
methods
will
be
subjected
critical
examination.
This
mode
fares
better
regarding
paracrine
signaling
immunomodulation
attributes,
which
cornerstone
tissue
regeneration
inflammation
reduction.
local
complications
technical
challenges
still
apply
this
method.
study
was
more
focused
on
further
research
soon
conducted
elucidate
long-term
safety
efficacy
cell
therapy.
Though
much
achieved
very
impressive
progress
field,
it
is
worth
noting
that
studies
need
put
place
so
technique
can
established
a
routine
approach,
especially
biomaterials,
gene
therapy,
personalized
medicine.
In
this
work,
we
reported
the
synthesis
of
honey
bee
(Apis
mellifera)
venom-derived
nanoparticles
via
a
hydrothermal
method.
This
method
not
only
ensures
preservation
venom's
bioactive
components
but
also
enhances
their
potential
stability,
thus
broadening
scope
for
applications
in
biomedicinal
field.
The
started
with
homogenization
suspension
venom,
followed
by
its
process
to
synthesize
venom
(BVNPs).
successful
BVNPs
was
characterized
using
various
characteristic
techniques
such
as
Ultraviolet-visible
(UV-Vis)
spectroscopy,
Fourier
Transforms
Infrared
(FTIR)
Spectroscopy,
Zeta
Potential
(ZP),
Liquid
Chromatography-Mass
Spectrometry
(LCMS),
and
Transmission
Electron
Microscopy
(TEM).
through
biosynthesis
is
shown
visible
violet-brown
color
development
at
347
nm
UV-Vis
spectroscopy.
FTIR
analysis
revealed
presence
several
functional
groups
BVNPs,
including
alcohols
(-OH),
phenols
(C
Stem Cells Translational Medicine,
Год журнала:
2024,
Номер
13(12), С. 1178 - 1185
Опубликована: Окт. 10, 2024
The
tumor
microenvironment
(TME)
significantly
influences
cancer
progression,
and
mesenchymal
stem
cells
(MSCs)
play
a
crucial
role
in
interacting
with
via
paracrine
signaling,
affecting
behaviors
such
as
proliferation,
migration,
epithelial-mesenchymal
transition.
While
conventional
2D
culture
models
have
provided
valuable
insights,
they
cannot
fully
replicate
the
complexity
diversity
of
TME.
Therefore,
developing
3D
systems
that
better
mimic
vivo
conditions
is
essential.
This
review
delves
into
heterogeneous
nature
TME,
spotlighting
MSC-tumor
cellular
signaling
advancements
technologies.
Utilizing
MSCs
therapy
presents
opportunities
to
enhance
treatment
effectiveness
overcome
resistance
mechanisms.
Understanding
MSC
interactions
within
TME
leveraging
can
advance
novel
therapies
improve
clinical
outcomes.
Additionally,
this
underscores
therapeutic
potential
engineered
MSCs,
emphasizing
their
targeted
anti-cancer
treatments.
