Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 309 - 340
Опубликована: Ноя. 29, 2024
Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102359 - 102359
Опубликована: Май 29, 2024
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10068 - 10068
Опубликована: Сен. 19, 2024
The emerging role of extracellular vesicles (EVs) in central nervous system (CNS) diseases is gaining significant interest, particularly their applications as diagnostic biomarkers and therapeutic agents. EVs are involved intercellular communication secreted by all cell types. They contain specific markers a diverse cargo such proteins, lipids, nucleic acids, reflecting the physiological pathological state originating cells. Their reduced immunogenicity ability to cross blood-brain barrier make them promising candidates for both In context CNS diseases, have shown promise isolable from different body fluids, providing non-invasive method diagnosing monitoring disease progression. This makes useful early detection Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, where alterations content can be detected. Additionally, derived stem cells show potential promoting tissue regeneration repairing damaged tissues. An evaluation has been conducted on current clinical trials studying focusing application, treatment protocols, obtained results. review aims explore carriers highlighting advantages ongoing evaluating efficacy.
Язык: Английский
Процитировано
6
Life, Год журнала: 2025, Номер 15(1), С. 70 - 70
Опубликована: Янв. 9, 2025
Extracellular vesicles (EVs) are nanosized, membrane-bound structures that have emerged as promising tools for drug delivery, especially in the treatment of lysosomal storage disorders (LSDs) with central nervous system (CNS) involvement. This review highlights unique properties EVs, such their biocompatibility, capacity to cross blood-brain barrier (BBB), and potential therapeutic cargo loading, including enzymes genetic material. Current therapies LSDs, like enzyme replacement therapy (ERT), often fail address neurological symptoms due inability BBB. EVs offer a viable alternative, allowing targeted delivery CNS improving outcomes. We discuss recent advancements engineering modification enhance targeting, circulation time stability, provide detailed overview application Gaucher Fabry diseases, Sanfilippo syndrome. Despite potential, challenges remain scaling production, ensuring isolation purity, meeting regulatory requirements. Future developments will focus on overcoming these barriers, paving way clinical translation EV-based LSDs other disorders.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141945 - 141945
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Март 19, 2025
Abstract Extracellular vesicles (EVs) are emerging as critical mediators of intercellular communication in the tumor microenvironment (TME), profoundly influencing cancer progression. These nano-sized vesicles, released by both and stromal cells, carry a diverse cargo proteins, nucleic acids, lipids, reflecting dynamic cellular landscape mediating intricate interactions between cells. This review provides comprehensive overview biogenesis, composition, functional roles EVs cancer, highlighting their significance basic research clinical applications. We discuss how cells manipulate EV biogenesis pathways to produce enriched with pro-tumorigenic molecules, explore specific contributions key hallmarks such angiogenesis, metastasis, immune evasion, emphasizing role shaping TME driving therapeutic resistance. Concurrently, we submit recent knowledge on can serve valuable source biomarkers for minimally invasive liquid biopsies, its potential, particularly targeted drug delivery vehicles immunomodulatory agents, showcasing promise enhancing efficacy safety treatments. By deciphering messages carried EVs, gain deeper understanding biology develop more effective strategies early detection, therapy, immunotherapy, paving way new era personalized precise medicine potential significantly improve patient outcomes.
Язык: Английский
Процитировано
0
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 203, С. 114470 - 114470
Опубликована: Авг. 26, 2024
Язык: Английский
Процитировано
1
Cancer Drug Resistance, Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements chemotherapeutic agents targeted therapies, cancers develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications delivery because of natural origin, biocompatibility, ability cross biological barriers. Using the unique properties EVs could enhance accumulation at target sites, minimize systemic toxicity, precisely specific cells. Here, we discuss characteristics functionalization EVs, mechanisms engineered overcome resistance. This review provides comprehensive overview EV-based systems overcoming We highlight revolutionize offer promising strategies more effective modalities.
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 309 - 340
Опубликована: Ноя. 29, 2024
Процитировано
0