Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics

Circulation Research, Год журнала: 2025, Номер 136(5), С. 524 - 550

Опубликована: Фев. 27, 2025

Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.

Язык: Английский

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Targeting sirtuins for cancer therapy: epigenetics modifications and beyond

Theranostics, Год журнала: 2024, Номер 14(17), С. 6726 - 6767

Опубликована: Янв. 1, 2024

Sirtuins (SIRTs) are well-known as nicotinic adenine dinucleotide

Язык: Английский

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Sirtuins and Resveratrol in Cardiorenal Diseases: A Narrative Review of Mechanisms and Therapeutic Potential

Nutrients, Год журнала: 2025, Номер 17(7), С. 1212 - 1212

Опубликована: Март 30, 2025

Aging is a very complex process, and it has been linked with Sirtuins. Sirtuin enzymes are family of deacetylases that related to caloric restriction aging by modulating energy metabolism, genomic stability, stress resistance. Up now, seven sirtuins have recognized. This narrative review aimed analyze the literature produced between January 2005 March 2025 evaluate role in chronic kidney disease and, as heart diseases strictly interrelated, explore their cardio-renal cross-talk. A reciprocal relationship CKD seems exist since may contribute premature biological different organ systems. SIRTs involved pathophysiology renal diseases; activation can delay progression several diseases. Notably, an increasing number studies CVDs. affect production mitochondrial reactive oxygen species (ROS) function. The imbalance SIRT levels increase vulnerability pathophysiological mechanisms HFpEF (heart failure preserved ejection fraction) through signaling pathways. Fibrosis linkage mechanism development Current on sirtuins, resveratrol, cardiorenal highlight potential therapeutic benefits regulating blood pressure, function, lipid profiles, inflammation, making them promising area investigation for improving cardiovascular health outcomes. However, significant gaps remain. limited availability highly selective potent sirtuin modulators hampers clinical translation, most existing compounds exhibit poor bioavailability suboptimal pharmacokinetic properties.

Язык: Английский

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Genome-wide identification and expression analysis of the SIRT gene family in Nile tilapia (Oreochromis niloticus)

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Год журнала: 2025, Номер 54, С. 101425 - 101425

Опубликована: Янв. 21, 2025

Язык: Английский

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Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment

Kidney International Reports, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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