The probiotic enhances donor microbiota stability and improves the efficacy of fecal microbiota transplantation for treating colitis
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1174 - 1174
Опубликована: Март 28, 2025
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
disease
affecting
the
colorectum,
posing
significant
global
health
burden.
Recent
studies
highlight
critical
role
of
gut
microbiota
and
its
metabolites,
particularly
bile
acids
(BAs),
in
UC's
pathogenesis.
The
relationship
between
BAs
bidirectional:
influence
BA
composition,
while
regulate
diversity
activity
through
receptors
like
Farnesoid
X
receptor
(FXR)
Takeda
G
protein-coupled
5
(TGR5).
Targeting
bile-acid
metabolism
to
reshape
presents
promising
therapeutic
strategy
for
UC.
This
review
examines
classification
synthesis
BAs,
their
interactions
with
microbiota,
potential
nutritional
microbial
interventions.
By
focusing
on
these
therapies,
we
aim
offer
innovative
approaches
effective
UC
management.
Язык: Английский
Vinegar-processed frankincense ameliorates ulcerative colitis by targeting BSH-active bacteria preference-mediated GDCA hydrolysis
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
348, С. 119845 - 119845
Опубликована: Апрель 24, 2025
Язык: Английский
Lacticaseibacillus paracasei JS-3 Isolated from “Jiangshui” Ameliorates Hyperuricemia by Regulating Gut Microbiota and iTS Metabolism
Foods,
Год журнала:
2024,
Номер
13(9), С. 1371 - 1371
Опубликована: Апрель 29, 2024
Background:
A
diet
high
in
purines
can
impair
the
function
of
gut
microbiota
and
disrupt
purine
metabolism,
which
is
closely
associated
with
onset
hyperuricemia.
Dietary
regulation
intestinal
health
maintenance
are
key
approaches
for
controlling
uric
acid
(UA)
levels.
Investigating
impacts
fermented
foods
offers
potential
dietary
interventions
managing
Methods:
In
this
study,
we
isolated
a
strain
potent
UA-degrading
capabilities
from
“Jiangshui”,
food
product
Gansu,
China.
We
performed
identification
assessed
its
probiotic
potential.
Hyperuricemic
quails,
induced
by
high-purine
diet,
were
used
to
assess
UA
degradation
capability
JS-3
measuring
levels
serum
feces.
Additionally,
pathways
elucidated
through
analyses
microbiome
fecal
metabolomics.
Results:
JS-3,
identified
as
Lacticaseibacillus
paracasei,
was
capable
eliminating
16.11%
within
72
h,
rapidly
proliferating
producing
12
surviving
gastrointestinal
tract.
Using
hyperuricemic
quail
models,
JS-3’s
capacity.
Two
weeks
after
administration
(2
×
108
cfu/d
per
quail),
(SUA)
significantly
decreased
normal
levels,
renal
damage
quails
markedly
improved.
Concurrently,
feces
group
demonstrated
significant
UA,
achieving
up
49%
24
h.
16S
rRNA
sequencing
revealed
role
restoration
augmenting
community
(Bifidobacterium,
Bacteroides
unclassified_f-Lachnospiraceae,
norank_fynorank_o-Clostridia_UCG-014)
diminishing
pathogenic
bacteria
(Macrococus
Lactococcus).
Corresponding
rise
short-chain
fatty
(SCFA)-producing
bacteria,
increased
SCFA
(p
<
0.05,
0.01).
ameliorated
metabolic
disturbances
influencing
26
abnormal
metabolites
predominantly
linked
purine,
tryptophan,
bile
thereby
enhancing
protection.
Conclusions:
For
first
time,
an
active
strain,
“Jiangshui”
treatment
It
modulates
host–microbiome
interactions,
metabolome,
enhances
degradation,
reduces
SUA
alleviates
damage,
effectively
treats
hyperuricemia
without
causing
damage.
summary,
serve
therapeutic
value
Язык: Английский
Modified Gegen Qinlian Decoction modulated the gut microbiome and bile acid metabolism and restored the function of goblet cells in a mouse model of ulcerative colitis
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 6, 2024
Modified
Gegen
Qinlian
Decoction
(MGQD)
has
been
shown
to
effectively
relieve
ulcerative
colitis
(UC)
without
a
known
pharmacological
mechanism.
In
this
study,
the
anti-colitis
efficaciousness
of
MGQD
and
its
underlying
mechanisms
in
UC
were
evaluated.
Язык: Английский
Important Role of Intestinal Microbiota in Chemotherapy-induced Diarrhea and Therapeutics
Journal of Cancer,
Год журнала:
2024,
Номер
16(2), С. 648 - 659
Опубликована: Дек. 31, 2024
Chemotherapy-induced
diarrhea
(CID)
is
a
common
and
harmful
side
effect
of
chemotherapy,
greatly
impacting
patients'
quality
life
potentially
compromising
their
chances
survival.Disruption
the
balance
in
intestinal
microbiota
compromised
integrity
barrier
are
key
factors
contributing
to
CID
caused
by
mucositis.This
paper
investigated
mechanism
through
which
activate
Toll-like
receptors
STING
pathways
mediate
mucosal
inflammation
resulting
from
immune
responses
gut,
uncovering
novel
chemotherapy-induced
diarrhea,
suggesting
innovative
approaches
for
prevention
management
CID.
Язык: Английский