Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut
Journal of Functional Foods,
Год журнала:
2024,
Номер
124, С. 106620 - 106620
Опубликована: Дек. 13, 2024
Язык: Английский
Bacterial profiles of the oral, vaginal, and rectal mucosa and colostrum of periparturient sows
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0317513 - e0317513
Опубликована: Фев. 12, 2025
The
commensal
microbiota
influences
the
health,
feeding
efficiency,
and
reproductive
performance
of
sows.
composition
in
alimentary
genitourinary
tracts
colostrum/milk
during
pregnancy
lactation
also
impacts
immune
system,
growth,
health
piglets.
Knowledge
microbial
compositions
is
important
for
evaluation
these
effects
discovering
ways
to
improve
productivity
Oral,
vaginal,
rectal
mucosa
colostrum
were
sampled
from
32
sows
variable
parity
late
pregnancy,
within
6
hours
delivery
first
piglet,
on
four
commercial
piglet-producing
farms
Finland.
Microbial
analyzed
by
16S
rRNA
gene
amplicon
sequencing.
most
abundant
genera
oral
Rothia
,
Moraxella
Streptococcus
.
was
dominated
Clostridium
sensu
stricto
1
genus
vagina
colostrum.
Moderate
differences
diversity
observed
between
farms.
relative
abundances
Neisseria
(MaAsLin
2
q
=
0.002,
ANCOMBC
0.005),
Fusobacterium
0.008,
0.04)
Bacteroides
<
0.005,
0.06)
lower
samples
Romboutsia
0.07,
0.05),
Turicibacter
0.08,
0.02)
Lachnospiraceae_UCG_007
0.1,
0.05)
higher
multiparous
compared
primiparous
In
vaginal
there
a
tendency
than
Among
differentially
taxa,
F
necrophorum
nucleatum
identified
samples,
gastrosuis
S
dysgalactiae
samples.
This
study
provides
comprehensive
overview
mucosal
periparturient
normal
production
conditions
Finnish
Язык: Английский
New insights into the cultivability of human milk bacteria from ingestion to digestion and implications for their Immunomodulatory properties
Charles Le Bras,
Alizé Mouchard,
Lucie Rault
и другие.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 31, 2025
Abstract
Human
milk
(HM)
microbiota
is
increasingly
studied
for
its
potential
health
benefits.
However,
the
physiological
state
of
HM
bacteria
and
consequently
their
effects
on
gut
homeostasis
remain
a
question.
This
study
investigated
by
characterizing
cultivable
fraction
as
it
might
be
at
point
ingestion
assessing
digestion,
in
specific
context
immature
infant
digestive
tract,
cultivability
immunomodulatory
properties
six
strains
representative
prevalent
genera
HM.
Twenty-eight
samples
were
analysed
16
S
metabarcoding
either
directly
raw
(raw
microbiota,
RM)
or
complete
obtained
from
seven
non-selective
media
(cultivable
CM).
approach
enabled
more
in-depth
investigation
CM
than
conventional
methods
based
individual
sequencing
subset
isolates
resulted
moderate
gain
diversity
within
each
sample.
It
confirmed
that
was
lower
RM,
with
~
7
versus
69
per
sample
RM
respectively,
an
under-representation
strictly
anaerobic
CM.
In
vitro
gastrointestinal
digestion
overall
good
survival
6
but
partial
loss
monocyte
THP1
cell
line,
except
Staphylococcus
epidermidis
strain
gained
potential.
These
results
highlight
to
survive
during
interact
intestinal
epithelium
immune
system,
well
importance
considering
process
when
evaluating
host-bacteria
interactions.
Язык: Английский
Uncovering the Effects of Different Formulae of Milk Powders on the Fecal Microorganisms and Metabolites of Bengal Tiger (Panthera tigris spp. tigris) Cubs
Animals,
Год журнала:
2025,
Номер
15(7), С. 1053 - 1053
Опубликована: Апрель 4, 2025
In
order
to
optimize
diets
for
Bengal
tiger
cubs
and
improve
their
health
condition
survival
rates,
we
conducted
microbiota
metabolomics
analyses
on
fecal
samples
from
fed
goat
dog
milk
replacer
formulae.
The
results
showed
that
there
were
significant
differences
in
microorganisms
metabolites
between
the
two
groups.
At
phylum
level,
major
components
of
microbial
composition
feces
Firmicutes,
Actinobacteriota,
Proteobacteria,
Bacteroidota
Fusobacteriota.
addition,
abundance
gut
varied
significantly
groups
cubs.
powder
exhibited
an
increase
probiotic
bacteria
(Anaerostipes
Clostridium_scindens)
(p
<
0.05),
community
tended
be
more
balanced.
Metabolomics
data
further
elucidated
feeding
different
formulae
affected
metabolic
pathways
group,
76
up-regulated
278
down-regulated
particularly
affecting
metabolism
vitamin
D3,
B5,
isoleucine,
valine,
phenylalanine
oleic
acid.
same
time,
19
including
amino
acid
metabolism,
lipid
nucleotide
pathways.
conclusion,
this
study
confirms
formula
affects
These
findings
may
provide
new
insights
into
how
dietary
strategies
influence
regulation
overall
Язык: Английский
Donor Human Milk Pasteurization Methods and the Effect on Milk Components as They Relate to Necrotizing Enterocolitis
Seminars in Fetal and Neonatal Medicine,
Год журнала:
2025,
Номер
unknown, С. 101638 - 101638
Опубликована: Апрель 1, 2025
Язык: Английский
Maternal co-exposure to Cd and PS-NPLs induces offspring ovarian inflammatory aging via promoting M1 macrophage polarization
Chemico-Biological Interactions,
Год журнала:
2025,
Номер
416, С. 111535 - 111535
Опубликована: Апрель 28, 2025
Язык: Английский
The Influence of Maternal Lifestyle Factors on Human Breast Milk Microbial Composition: A Narrative Review
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2423 - 2423
Опубликована: Окт. 22, 2024
Human
breast
milk
(HBM)
is
considered
the
gold
standard
for
infant
nutrition
due
to
its
optimal
nutrient
profile
and
complex
composition
of
cellular
non-cellular
components.
Breastfeeding
positively
influences
newborn's
gut
microbiota
health,
reducing
risk
conditions
like
gastrointestinal
infections
chronic
diseases
(e.g.,
allergies,
asthma,
diabetes,
obesity).
Research
has
revealed
that
HBM
contains
beneficial
microbes
aid
maturation
through
mechanisms
antimicrobial
production
pathogen
exclusion.
The
can
be
affected
by
several
factors,
including
gestational
age,
delivery
mode,
medical
treatments,
lactation
stage,
as
well
maternal
lifestyle
habits
diet,
physical
activity,
sleep
quality,
smoking,
alcohol
consumption,
stress
level).
Particularly,
factors
play
a
significant
role
in
shaping
directly
modulating
microbial
or
influencing
enteromammary
pathway.
This
narrative
review
current
findings
summarized
how
microbiota.
While
influence
diet
on
well-documented,
indicating
dietary
patterns,
especially
those
rich
plant-based
proteins
carbohydrates,
microbiota,
impact
other
poorly
investigated.
Maintaining
healthy
during
pregnancy
breastfeeding
crucial
health
both
mother
baby.
Understanding
colonization
HBM,
along
with
their
interactions
impact,
key
developing
new
strategies
support
infant's
Язык: Английский
New insights into the cultivability of human milk microbiota from ingestion to digestion and implications for its immunomodulatory properties
Charles Le Bras,
Alizé Mouchard,
Lucie Rault
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
Abstract
Human
milk
(HM)
microbiota
is
increasingly
studied
for
its
potential
health
benefits.
However,
the
physiological
state
of
HM
bacteria
and
consequently
their
effects
on
gut
homeostasis
remain
a
question.
This
study
investigated
by
characterizing
cultivable
fraction,
as
it
might
be
at
point
ingestion
assessing
digestion
cultivability
immunomodulatory
properties
six
prevalent
strains.
The
28
samples
was
analysed
16S
metabarcoding
either
directly
raw
(raw
microbiota,
RM)
or
complete
fraction
obtained
from
seven
non-selective
media
(cultivable
CM).
Diversity
lower
in
CM
than
RM,
with
32
versus
435
genera
median
7
69
per
sample
respectively.
also
showed
under-representation
strictly
anaerobic
genera.
Factors
like
parity
iron
vitamin
supplementation
affected
RM
and/or
CM.
In
vitro
gastrointestinal
moderately
impacted
strain
cultivability.
most
strains
partially
completely
lost
monocyte
THP1
cell
line
after
digestion,
except
Staphylococcus
epidermidis
that
gained
potential.
Язык: Английский