Introduction
Cancer
remains
a
significant
health
challenge,
and
nanoparticles
(NPs)
are
promising
candidates
for
cancer
treatment
due
to
their
unique
physicochemical
properties
ability
selectively
target
tumour
cells.
Two-dimensional
(2D)
nanomaterials,
such
as
MXenes,
have
attracted
interest
electronic
structures,
optical
properties,
catalytic
abilities,
exceptional
attributes.
MXenes
highly
suitable
surface
functionalization
or
modification,
make
them
various
applications
in
the
biological
field.
Silver-based
compounds
shown
remarkable
potential
biomedical
fields,
with
silver
oxide
(Ag₂O)
NPs
finding
domains.
The
fabrication
of
titanium
carbide
(Ti₃C₂)-Ag₂O
heterostructures
has
been
investigated
anti-cancer
by
conducting
cell
viability
assays
on
different
lines.
Aim
To
synthesize
characterize
Ti₃C₂-Ag₂O,
assess
its
vitro
activity.
Materials
methods
Ti₃C₂
synthesis
begins
dissolving
Ti₃AlC₂
powder
50%
v/v
hydrofluoric
(HF)
acid
solution,
allowing
aluminium
be
etched
away.
This
process
should
conducted
continuous
stirring
24
48
hours
at
ambient
temperature.
Following
this,
filter
resulting
suspension
eliminate
particles
HF,
subsequently
wash
MXene
distilled
water
until
neutral
pH
is
attained.
then
dispersed
ethanol,
sonication
deionized
(DI)
an
alternative
solvent
employed
achieve
exfoliation
into
monolayer
few-layer
MXenes.
prepare
Ag₂O
NPs,
dissolve
nitrate
(AgNO₃)
DI
create
0.1
M
concurrently
separate
sodium
hydroxide
(NaOH)
solution.
Introduce
NaOH
solution
AgNO₃
while
precipitate
observed.
mixture
filtered,
washed
water,
dried
60°C
12
hours.
fabricate
MXene-Ag₂O
composite,
disperse
nanoflakes
through
sonication,
incorporate
stir
Finally,
centrifuge
resultant
isolate
it
solvent,
dry
under
vacuum
conditions.
Results
presence
nanosheets
was
observed,
high
crystallinity
compound
confirmed
X-ray
diffraction
(XRD),
energy-dispersive
spectroscopy
(EDS),
scanning
electron
microscopy
(SEM)
analyses.
These
tests
verified
that
free
impurities
exhibited
properties.
Conclusion
achieved
structural
characterization
methods,
including
SEM,
XRD,
EDS.
SEM
provided
detailed
insights
morphology
distribution
nanostructures,
XRD
EDS
phase
purity
elemental
composition.
Functionalization
strategies
were
enhance
stability
bioactivity
nanocomposites.
In
evaluations
demonstrated
activity,
indicating
Ti₃C₂-Ag₂O
composites
effectively
inhibit
growth.
Life Sciences,
Год журнала:
2024,
Номер
352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 26, 2025
Extracellular
vesicles
(EVs),
as
cell-derived
small
vesicles,
facilitate
intercellular
communication
within
the
tumor
microenvironment
(TME)
by
transporting
biomolecules.
EVs
from
different
sources
have
varied
contents,
demonstrating
differentiated
functions
that
can
either
promote
or
inhibit
cancer
progression.
Thus,
regulating
formation,
secretion,
and
intake
of
becomes
a
new
strategy
for
intervention.
Advancements
in
EV
isolation
techniques
spurred
interest
EV-based
therapies,
particularly
immunotherapy.
This
review
explores
multifaceted
various
immunotherapy,
highlighting
their
potential
vaccines
adoptive
cell
therapy.
Furthermore,
we
explore
nanoparticle
delivery
systems
Finally,
discuss
current
state
clinical
settings
future
directions,
aiming
to
provide
crucial
information
advance
development
application
treatment.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Ноя. 30, 2024
Abstract
Ferroptosis
is
a
type
of
regulated
cell
death
characterized
by
its
non-apoptotic,
iron-dependent
and
oxidative
nature.
Since
discovery
in
2012,
extensive
research
has
demonstrated
pivotal
roles
tumorigenesis,
metastasis
cancer
therapy.
The
tumor
microenvironment
(TME)
complex
ecosystem
comprising
cells,
non-cancer
extracellular
matrix,
metabolites
cytokines.
Recent
studies
have
underscored
new
paradigm
which
cells
the
TME,
such
as
immune
stromal
also
play
significant
regulating
progression
therapeutic
resistance
typically
through
complicated
crosstalk
with
cells.
Notably,
this
TME
were
partially
mediated
ferrotopsis-related
mechanisms.
This
review
provides
comprehensive
systematic
summary
current
findings
concerning
ferroptosis
how
ferroptosis-mediated
reprogramming
impacts
progression.
Additionally,
outlines
various
ferroptosis-related
strategies
aimed
at
targeting
TME.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 5 - 5
Опубликована: Фев. 4, 2025
This
research
describes
the
development
and
thorough
characterization
of
a
novel,
versatile,
biocompatible
hybrid
nanocarrier
NO-releasing
agent
NOC-18,
with
specific
focus
on
optimizing
purification
process.
In
this
study,
we
focused
sustained
release
NO
using
diagnostic
magnetic
nanoparticles
(hMNPs)
containing
cerium-doped
maghemite
(CM)
NPs,
embedded
within
human
serum
albumin
(HSA)
protein.
A
comprehensive
study
was
conducted
electron
paramagnetic
resonance
(EPR)
alongside
Griess
assay
to
evaluate
from
chosen
donor,
assess
limitations
molecule
under
various
reaction
conditions,
identifying
optimal
conditions
for
binding
NOC-18
minimal
loss.
Two
types
particles
were
designed:
In-hMNPs,
where
is
encapsulated
particles,
Out-hMNPs,
attached
onto
surface.
Our
results
demonstrated
that
In-hMNPs
provided
prolonged
(half-life,
50
h)
compared
rapid
likely
due
strong
bonds
formed
cerium,
which
helped
stabilize
molecules.
These
represent
promising
approach
designing
dual-function
combines
contrast
properties
tumor
MRI
possibility
increasing
permeability
vasculature.
The
employment
in
combination
nanotherapeutics
could
improve
latter’s
efficacy
by
facilitating
their
access
tumor.
RSC Advances,
Год журнала:
2025,
Номер
15(7), С. 5558 - 5570
Опубликована: Янв. 1, 2025
Background:
H.
pylori
is
recognized
as
one
of
the
main
causes
gastric
cancer,
and
this
type
cancer
considered
leading
diseases
causing
deaths
all
over
world.
