Introduction
Cancer
remains
a
significant
health
challenge,
and
nanoparticles
(NPs)
are
promising
candidates
for
cancer
treatment
due
to
their
unique
physicochemical
properties
ability
selectively
target
tumour
cells.
Two-dimensional
(2D)
nanomaterials,
such
as
MXenes,
have
attracted
interest
electronic
structures,
optical
properties,
catalytic
abilities,
exceptional
attributes.
MXenes
highly
suitable
surface
functionalization
or
modification,
make
them
various
applications
in
the
biological
field.
Silver-based
compounds
shown
remarkable
potential
biomedical
fields,
with
silver
oxide
(Ag₂O)
NPs
finding
domains.
The
fabrication
of
titanium
carbide
(Ti₃C₂)-Ag₂O
heterostructures
has
been
investigated
anti-cancer
by
conducting
cell
viability
assays
on
different
lines.
Aim
To
synthesize
characterize
Ti₃C₂-Ag₂O,
assess
its
vitro
activity.
Materials
methods
Ti₃C₂
synthesis
begins
dissolving
Ti₃AlC₂
powder
50%
v/v
hydrofluoric
(HF)
acid
solution,
allowing
aluminium
be
etched
away.
This
process
should
conducted
continuous
stirring
24
48
hours
at
ambient
temperature.
Following
this,
filter
resulting
suspension
eliminate
particles
HF,
subsequently
wash
MXene
distilled
water
until
neutral
pH
is
attained.
then
dispersed
ethanol,
sonication
deionized
(DI)
an
alternative
solvent
employed
achieve
exfoliation
into
monolayer
few-layer
MXenes.
prepare
Ag₂O
NPs,
dissolve
nitrate
(AgNO₃)
DI
create
0.1
M
concurrently
separate
sodium
hydroxide
(NaOH)
solution.
Introduce
NaOH
solution
AgNO₃
while
precipitate
observed.
mixture
filtered,
washed
water,
dried
60°C
12
hours.
fabricate
MXene-Ag₂O
composite,
disperse
nanoflakes
through
sonication,
incorporate
stir
Finally,
centrifuge
resultant
isolate
it
solvent,
dry
under
vacuum
conditions.
Results
presence
nanosheets
was
observed,
high
crystallinity
compound
confirmed
X-ray
diffraction
(XRD),
energy-dispersive
spectroscopy
(EDS),
scanning
electron
microscopy
(SEM)
analyses.
These
tests
verified
that
free
impurities
exhibited
properties.
Conclusion
achieved
structural
characterization
methods,
including
SEM,
XRD,
EDS.
SEM
provided
detailed
insights
morphology
distribution
nanostructures,
XRD
EDS
phase
purity
elemental
composition.
Functionalization
strategies
were
enhance
stability
bioactivity
nanocomposites.
In
evaluations
demonstrated
activity,
indicating
Ti₃C₂-Ag₂O
composites
effectively
inhibit
growth.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 296 - 296
Опубликована: Фев. 24, 2025
Melanoma,
a
highly
aggressive
form
of
skin
cancer,
poses
major
therapeutic
challenge
due
to
its
metastatic
potential,
resistance
conventional
therapies,
and
the
complexity
tumor
microenvironment
(TME).
Materials
science
nanotechnology
advances
have
led
using
nanocarriers
such
as
liposomes,
dendrimers,
polymeric
nanoparticles,
metallic
nanoparticles
transformative
solutions
for
precision
melanoma
therapy.
This
review
summarizes
findings
from
Web
Science,
PubMed,
EMBASE,
Scopus,
Google
Scholar
highlights
role
in
overcoming
treatment
barriers.
Nanoparticles
facilitate
passive
active
targeting
through
mechanisms
enhanced
permeability
retention
(EPR)
effect
functionalization
with
tumor-specific
ligands,
thereby
improving
accuracy
drug
delivery
reducing
systemic
toxicity.
Stimuli-responsive
systems
multi-stage
further
improve
overcome
challenges
poor
penetration
resistance.
Emerging
platforms
combine
diagnostic
imaging
delivery,
paving
way
personalized
medicine.
However,
there
are
still
issues
scalability,
biocompatibility,
regulatory
compliance.
comprehensive
potential
integrating
genetics
proteomics,
scalable,
patient-specific
therapies.
These
interdisciplinary
innovations
promise
redefine
provide
safer,
more
effective,
accessible
treatments.
Continued
research
is
essential
bridge
gap
between
evidence-based
scientific
clinical
applications.
Nanoenergy Advances,
Год журнала:
2025,
Номер
5(2), С. 4 - 4
Опубликована: Март 31, 2025
Nowadays,
due
to
improvements
in
living
standards,
more
attention
is
reserved
all-around
disease
prevention
and
health
care.
In
particular,
research
efforts
have
been
made
for
developing
novel
methods
treatments
anti-cancer
therapy.
Self-powered
nanogenerators
emerged
recent
years
as
an
attractive
cost-effective
technology
harvest
energy
or
biosensing
applications.
Bioelectronic
can
be
used
inducing
tissue
recovery
treating
human
illness
through
electrical
stimulation.
However,
there
still
a
lack
of
comprehensive
cognitive
assessment
these
devices
platforms,
especially
regarding
which
requirements
must
satisfied
working
principles
transduction
adopted
effectively
the
body.
This
review
covers
most
advances
bioelectronic
therapy,
based
on
different
transducing
strategies
(photodynamic
drug
delivery,
stimulation,
atomic
nanogenerators,
etc.),
potential
mechanisms
repair
promotion
are
discussed.
The
prospective
challenges
finally
summarized
with
indication
future
outlook.
Advanced Electronic Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Biophotonics
has
gained
significant
interest
in
recent
years
due
to
its
potential
medical
theranostic
applications,
with
nano‐materials
emerging
as
key
enablers
for
advancing
optical
and
electronic
functionalities
biological
environments.
In
this
study,
conjugated
polymer
nanoparticles
(CP‐NPs),
namely
regio‐regular
poly(3‐hexylthiophene)
(P3HT),
[6,6]‐phenyl
C61‐butyric
acid
methyl
ester
(PCBM),
their
blend
(P3HT:PCBM),
are
exploited
biophotonic
applications.
The
CP‐NPs,
obtained
via
a
nanoprecipitation
method,
showed
an
average
size
of
ca.
180
nm.
Their
optoelectrical
properties
indicate
visible
absorbance
(350–600
nm)
red/near
infra‐red
(NIR,
650–900
emission,
demonstrating
suitability
particular
biohybrid
interfaces
where
effective
light
absorption
emission
environments
crucial.
Interestingly,
under
stimulation,
the
photocurrent
response
CP‐NPs
electrolyte
solution
(phosphate‐buffered
saline,
PBS)
stable
reproducible
signal
(current
density
ranging
from
0.18
7
nA
cm
−2
)
thereby
enhancing
bio‐sensing/stimulation.
Simulations
interactions
fluids
(i.e.,
stimulation
distinct
carrier
generation
transport
behaviors,
P3HT‐NPs
exhibiting
consistent
charge
(up
3
×
10
20
−3
).
These
findings
demonstrate
that
promising
such
photothermal
therapy,
efficient
transport,
UV‐vis
absorption,
NIR
controlled
Journal of Drug Delivery and Therapeutics,
Год журнала:
2025,
Номер
15(4), С. 133 - 143
Опубликована: Апрель 15, 2025
Nanoparticles
(NPs)-based
drug
delivery
systems
(DDs)
have
emerged
as
a
promising
strategy
for
cancer
therapy,
offering
targeted,
controlled,
and
efficient
while
minimizing
systemic
toxicity.
Their
unique
physicochemical
properties,
including
high
surface
area,
tunable
size,
enhanced
permeability,
enable
precise
tumor
targeting
through
passive,
active,
stimuli-responsive
mechanisms.
The
various
nanocarriers
such
liposomes,
polymeric
NPs,
dendrimers,
metallic
NPs
been
extensively
explored
chemotherapy,
gene
immunotherapy,
theranostic
applications.
ability
of
to
overcome
multidrug
resistance
(MDR),
enhance
bioavailability,
facilitate
combination
therapies
has
significantly
improved
treatment
outcomes.
Despite
the
remarkable
advancements,
challenges
biocompatibility,
large-scale
production,
regulatory
approval
remain
critical
hurdles.
Future
research
will
focus
on
personalized
nanomedicine,
smart
multifunctional
nanocarriers,
gene-editing
nanoparticle
systems,
green
nanotechnology
safer
more
effective
treatments.
continuous
evolution
in
therapy
holds
immense
potential
transform
oncology,
paving
way
patient-specific,
minimally
invasive,
highly
modalities.
This
review
article
focuses
lipid-based,
polymeric,
inorganic
nanoparticles
system
their
applications
therapy.
current
limitations
future
perspectives
nanoparticle-based
DDS
are
also
discussed.
Keywords:
Drug
delivery,
Nanocarriers,
NDDS,
Sustained,
Targeted
