Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157288 - 157288
Опубликована: Ноя. 1, 2024
Язык: Английский
Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 659 - 677
Опубликована: Окт. 28, 2024
Язык: Английский
Процитировано
7
Experimental Cell Research, Год журнала: 2024, Номер 442(1), С. 114198 - 114198
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
6
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177309 - 177309
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 43
Опубликована: Фев. 19, 2025
In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113606 - 113606
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2025, Номер 12(4), С. 341 - 341
Опубликована: Март 26, 2025
Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, negative impacts healthy tissues. In addressing challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical biological to specifically target tumor cells while reducing damage normal This review examines several strategies, such high-intensity focused energy beams, nanosecond pulsed electric fields, photothermal therapy well the use of inorganic nanoparticles promote selective apoptosis. We also investigate significance targeting microenvironment, precision medicine, immunotherapy in progression personalized therapies. Although approaches demonstrate significant promise, challenges scalability, safety, regulatory obstacles must be resolved for clinical application. paper presents an overview current research therapies, emphasizing recent advancements, underlying scientific principles, steps required implementation.
Язык: Английский
Процитировано
0
Journal of the National Cancer Center, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 12, 2024
The tumor microenvironment (TME) plays a crucial role in cancer development and metastasis. This review summarizes the current research on how TME promotes metastasis through molecular pathways, focusing key components, such as cancer-associated fibroblasts, immune cells, endothelial cytokines, extracellular matrix. Significant findings have highlighted that alterations cellular communication within enable cells to evade surveillance, survive, invade other tissues. highlights roles of TGF-β VEGF signaling promoting angiogenesis matrix remodeling, which facilitate Additionally, we explored metabolic reprogramming stromal influenced by nutrient availability TME, drives progression. study also evaluated therapeutic strategies targeting these interactions disrupt By providing multidisciplinary perspective, this suggests understanding basis can lead more effective therapies identify potential avenues for future research. Future should prioritize unraveling complex environment, could novel personalized treatments. Moreover, advancements technologies single-cell analysis, spatial transcriptomics, epigenetic profiling offer promising identifying new targets improving efficacy immunotherapies, particularly context
Язык: Английский
Процитировано
3
Frontiers in Genome Editing, Год журнала: 2024, Номер 6
Опубликована: Дек. 12, 2024
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged a potent gene-editing tool after the successful engineering of synthetic guide RNA (sgRNA) toward targeting specific DNA sequences with high accuracy. Besides editing ability, further-developed Cas variants can also edit epigenome, rendering versatile for genome epigenome manipulation pioneering force precision medicine. This review explores latest technology therapeutic biomedical applications, highlighting transformative impact on Moreover, current status CRISPR therapeutics clinical trials is discussed. Finally, we address persisting challenges prospects technology.
Язык: Английский
Процитировано
2