The pathobiology of neurovascular aging
Neuron,
Год журнала:
2025,
Номер
113(1), С. 49 - 70
Опубликована: Янв. 1, 2025
Язык: Английский
A proposed role for lymphatic supermicrosurgery in the management of Alzheimer’s disease: A primer for reconstructive microsurgeons
Archives of Plastic Surgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
The
relatively
recent
discovery
of
a
novel
lymphatic
system
within
the
brain
meninges
has
spurred
interest
in
how
waste
products
generated
by
neurons
and
glial
cells—including
proteins
associated
with
Alzheimer's
disease
(AD)
pathology
such
as
amyloid
beta
(Aβ)
tau—are
disposed
of.
Evidence
is
building
that
suggests
progression
AD
other
cognitive
impairments
could
be
explained
dysfunction
brain's
or
obstruction
drainage.
An
interesting
implication
this
hypothesis
that,
relieving
flow,
reconstruction
along
drainage
pathway
serve
potential
treatment.
Should
concept
prove
true,
it
represent
surgical
solution
to
problem
for
which
only
medical
solutions
have
thus
far
been
considered.
This
study
meant
primer
reconstructive
microsurgeons,
introducing
topic
current
hypotheses
about
role
AD.
A
preview
research
evaluating
feasibility
approach
improving
Aβ
clearance
provided,
aim
inspiring
others
design
robust
preclinical
clinical
investigations
into
intriguing
hypothesis.
Язык: Английский
Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis
The Journal of Experimental Medicine,
Год журнала:
2024,
Номер
222(2)
Опубликована: Дек. 24, 2024
Dysfunctional
lymphatic
drainage
from
the
central
nervous
system
(CNS)
has
been
linked
to
neuroinflammatory
and
neurodegenerative
disorders,
but
our
understanding
of
contribution
CNS
fluid
autoregulation
remains
limited.
Here,
we
studied
forces
that
drive
outflow
cerebrospinal
(CSF)
into
deep
superficial
cervical
lymph
nodes
(dcLN
scLN)
tested
how
blockade
networks
affects
homeostasis.
Outflow
dcLN
occurred
spontaneously
in
absence
pumping
was
coupled
intracranial
pressure
(ICP),
whereas
scLN
driven
by
pumping.
Impaired
led
elevated
CSF
resistance
delayed
CSF-to-blood
efflux
despite
recruitment
nasal-to-scLN
pathway.
Fluid
regulation
better
compensated
after
obstruction.
The
pathway
exhibited
steady,
consistent
across
conditions,
while
dynamically
activated
mitigate
perturbances.
These
findings
highlight
complex
physiology
homeostasis
lay
groundwork
for
future
studies
aimed
at
assessing
modulating
function.
Язык: Английский