Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent DOI Creative Commons
Jieyu Chen,

Jianzhun Chen,

Chunyu Liang

и другие.

Neuroprotection/Neuroprotection (Chichester, England. Print), Год журнала: 2024, Номер 2(4), С. 310 - 317

Опубликована: Дек. 1, 2024

Abstract Background Observational studies have indicated a link between liver enzymes and dementia, but the causal relationship remains uncertain. We conducted two‐sample Mendelian randomization (MR) study to investigate potential links function markers (alanine aminotransferase [ALT], aspartate [AST], alkaline phosphatase [ALP], γ‐glutamyltransferase [GGT]) various forms of dementia (all‐cause Alzheimer's disease [AD], vascular [VaD], frontotemporal [FTD]). Methods Genome‐wide association (GWAS) data enzyme levels with 517 single nucleotide polymorphisms from 315,572 individuals European descent were considered as exposures. Additional GWAS on FinnGen consortium UK Biobank used outcomes. The was evaluated using univariable MR (UVMR) multivariable (MVMR) methods. UVMR approaches such inverse variance weighting (IVW), MR‐Egger, weighted median, simple mode, mode used, IVW primary. MVMR techniques, extended versions IVW, Q‐minimization methods, assess effects. robustness analysis findings verified through heterogeneity, horizontal pleiotropy, leave‐one‐out analyses. Results demonstrated that genetically determined one standard deviation rise in blood GGT associated an increased risk VaD (IVW: odds ratio = 1.007, 95% confidence interval 1.002–1.011, p 0.010). These remained consistent after adjusting for confounding variables analysis. Sensitivity analyses further supported relationship. However, no significant observed ALT, AST, ALP, all‐cause VaD, AD, or FTD. Conclusions Our suggests clinical implications, demonstrating high concentrations are factors populations. Further research is needed uncover underlying biological mechanisms validate relevance early prevention intervention strategies.

Язык: Английский

Spatial metabolic modulation in vascular dementia by Erigeron breviscapus injection using ambient mass spectrometry imaging DOI
Shuohan Cheng, Wenbin Zhou, Yang Ren

и другие.

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156412 - 156412

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Unraveling the role of brain renin angiotensin system in vascular dementia: mechanisms and therapeutic perspectives DOI

Kuldeep Kumar,

Sonal Aggarwal,

Ayush Kandpal

и другие.

Experimental Brain Research, Год журнала: 2025, Номер 243(5)

Опубликована: Апрель 26, 2025

Язык: Английский

Процитировано

0
Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients DOI Creative Commons
Yachen Shi, Min Xu,

Feng Wang

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(11)

Опубликована: Ноя. 1, 2024

ABSTRACT Aims The study attempted to determine the underlying role and regulation mechanism of 3β‐hydroxysterol‐Δ24 reductase (DHCR24) in pathophysiology cerebral small vessel disease‐associated cognitive impairment (CSVD‐CI). An RNA high‐throughput sequencing independent verification were conducted identify potential circRNAs becoming upstream regulator. Methods was performed whole‐blood samples cohort 1 (10 CSVD‐CI 8 CSVD with cognitively normal [CSVD‐CN] patients). DHCR24 candidate verified an 2 (45 participants 37 CSVD‐CN ones). also analyzed comprehensive assessments, plasma molecular index, brain structure imaging. Results expression has_circ_0015335 patients significantly reduced compared verification. Furthermore, levels related global patients. Meanwhile, could regulate correlation between alterations cortex surface area, thickness, volume Additionally, hsa_circ_0015335 interacted for 24(S)‐hydroxycholesterol among Conclusion Interaction impaired by affecting cholesterol metabolism structural changes.

Язык: Английский

Процитировано

1
Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent DOI Creative Commons
Jieyu Chen,

Jianzhun Chen,

Chunyu Liang

и другие.

Neuroprotection/Neuroprotection (Chichester, England. Print), Год журнала: 2024, Номер 2(4), С. 310 - 317

Опубликована: Дек. 1, 2024

Abstract Background Observational studies have indicated a link between liver enzymes and dementia, but the causal relationship remains uncertain. We conducted two‐sample Mendelian randomization (MR) study to investigate potential links function markers (alanine aminotransferase [ALT], aspartate [AST], alkaline phosphatase [ALP], γ‐glutamyltransferase [GGT]) various forms of dementia (all‐cause Alzheimer's disease [AD], vascular [VaD], frontotemporal [FTD]). Methods Genome‐wide association (GWAS) data enzyme levels with 517 single nucleotide polymorphisms from 315,572 individuals European descent were considered as exposures. Additional GWAS on FinnGen consortium UK Biobank used outcomes. The was evaluated using univariable MR (UVMR) multivariable (MVMR) methods. UVMR approaches such inverse variance weighting (IVW), MR‐Egger, weighted median, simple mode, mode used, IVW primary. MVMR techniques, extended versions IVW, Q‐minimization methods, assess effects. robustness analysis findings verified through heterogeneity, horizontal pleiotropy, leave‐one‐out analyses. Results demonstrated that genetically determined one standard deviation rise in blood GGT associated an increased risk VaD (IVW: odds ratio = 1.007, 95% confidence interval 1.002–1.011, p 0.010). These remained consistent after adjusting for confounding variables analysis. Sensitivity analyses further supported relationship. However, no significant observed ALT, AST, ALP, all‐cause VaD, AD, or FTD. Conclusions Our suggests clinical implications, demonstrating high concentrations are factors populations. Further research is needed uncover underlying biological mechanisms validate relevance early prevention intervention strategies.

Язык: Английский

Процитировано

0