Molecular mechanisms of GDNF/GFRA1/RET and PI3K/AKT/ERK signaling interplay in neuroprotection: Therapeutic strategies for treating neurological disorders
Neuropeptides,
Год журнала:
2025,
Номер
111, С. 102516 - 102516
Опубликована: Март 12, 2025
Язык: Английский
Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease
Metabolites,
Год журнала:
2025,
Номер
15(3), С. 210 - 210
Опубликована: Март 20, 2025
Tryptophan
is
an
essential
amino
acid
critical
for
human
health.
It
plays
a
pivotal
role
in
numerous
physiological
and
biochemical
processes
through
its
metabolism.
The
kynurenine
(KYN)
pathway
serves
as
the
principal
metabolic
route
tryptophan,
producing
bioactive
metabolites,
including
KYN,
quinolinic
acid,
3-hydroxykynurenine.
Numerous
studies
are
actively
investigating
relationship
between
tryptophan
metabolism
functions.
These
highlighting
interactions
among
metabolites
that
may
exert
synergistic
or
antagonistic
effects,
such
neuroprotective
neurotoxic,
pro-oxidative
antioxidant
activities.
Minor
disruptions
homeostasis
of
these
can
result
immune
dysregulation,
contributing
to
spectrum
diseases.
diseases
include
neurological
disorders,
mental
illnesses,
cardiovascular
conditions,
autoimmune
diseases,
chronic
kidney
disease.
Therefore,
understanding
roles
KYN
elucidating
contribution
health
regulation.
present
review
emphasizes
their
mechanisms
disease
development,
aiming
establish
theoretical
basis
leveraging
dietary
nutrients
enhance
Язык: Английский
Lamin A/C regulates cerebellar granule cell maturation
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Апрель 5, 2025
Abstract
Lamin
A/C
is
a
nuclear
type
V
intermediate
filament
protein
part
of
the
meshwork
structure
underlying
inner
membrane
(nuclear
lamina),
which
plays
numerous
roles,
including
maintenance
shape,
heterochromatin
organization,
and
transcriptional
regulation.
Our
group
has
demonstrated
role
in
different
pathophysiological
conditions.
Here,
we
investigated
for
first
time
how
affects
neuronal
maturation
rat
cerebellar
granule
cells
(GCs).
Primary
GCs
where
silenced
Lmna
gene
constituted
our
key
model;
this
provided
rather
homogeneous
cellular
system
showing
population
vitro.
We
then
validated
findings
another
vivo
murine
model
with
knock-out
an
vitro
human
silencing
LMNA
gene.
observed
across
three
models
that
down-regulation
neurons
by
protecting
from
glutamate-evoked
excitotoxicity
correlates
inhibition
calcium
influxes
pro-inflammatory
cytokine
pathways.
Consistent
previous
group,
study
corroborates
neural
development
opens
new
significant
implications
better
comprehension
mechanisms
involved
neurodegenerative
diseases,
changes
envelope
are
linked
to
neuroinflammatory
processes
damage.
Язык: Английский
Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Mitochondrial
dysfunction
plays
a
pivotal
role
in
the
development
of
age-related
diseases,
particularly
neurodegenerative
disorders.
The
etiology
mitochondrial
involves
multitude
factors
that
remain
elusive.
This
review
centers
on
elucidating
role(s)
excitotoxicity,
oxytosis/ferroptosis
and
neurodegeneration
within
context
bioenergetics,
biogenesis,
mitophagy
oxidative
stress
explores
their
intricate
interplay
pathogenesis
diseases.
effective
coordination
turnover
processes,
notably
is
assumed
to
be
critically
important
for
cellular
resilience
longevity.
However,
age-associated
decrease
impedes
elimination
dysfunctional
mitochondria,
consequently
impairing
biogenesis.
deleterious
cascade
results
accumulation
damaged
mitochondria
deterioration
functions.
Both
excitotoxicity
have
been
demonstrated
contribute
significantly
pathophysiology
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
Disease
(HD),
Amyotrophic
Lateral
Sclerosis
(ALS)
Multiple
(MS).
Excitotoxicity,
characterized
by
excessive
glutamate
signaling,
initiates
events
involving
calcium
dysregulation,
energy
depletion,
intricately
linked
dysfunction.
Furthermore,
emerging
concepts
surrounding
underscore
importance
iron-dependent
lipid
peroxidation
engagement
neurodegeneration.
not
only
discusses
individual
contributions
ferroptosis
but
also
emphasizes
convergence
with
dysfunction,
key
driver
Understanding
crosstalk
between
oxytosis/ferroptosis,
holds
potential
pave
way
mitochondrion-targeted
therapeutic
strategies.
Such
strategies,
focus
mitophagy,
stress,
emerge
as
promising
avenues
intervention.
Язык: Английский
Bridging the Gap: Prenatal Nutrition, Myelination, and Schizophrenia Etiopathogenesis
Neuroscience,
Год журнала:
2024,
Номер
558, С. 58 - 69
Опубликована: Авг. 17, 2024
Язык: Английский
Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target
Molecules,
Год журнала:
2024,
Номер
29(23), С. 5744 - 5744
Опубликована: Дек. 5, 2024
Gamma-glutamate
is
an
important
excitatory
neurotransmitter
in
the
central
nervous
system
(CNS),
which
plays
role
transmitting
synapses,
plasticity,
and
other
brain
activities.
Nevertheless,
alterations
glutamatergic
signaling
pathway
are
now
accepted
as
a
element
Alzheimer's
disease
(AD)
pathophysiology.
One
of
most
prevalent
types
dementia
older
adults
AD,
progressive
neurodegenerative
illness
brought
on
by
persistent
decline
cognitive
function.
Since
AD
has
been
shown
to
be
multifactorial,
variety
pharmaceutical
targets
may
used
treat
condition.
N-methyl-D-aspartic
acid
receptor
(NMDAR)
antagonists
acetylcholinesterase
inhibitors
(AChEIs)
two
drug
classes
that
Food
Drug
Administration
authorized
for
treatment
AD.
The
AChEIs
approved
galantamine,
donepezil,
rivastigmine.
However,
memantine
only
non-competitive
NMDAR
antagonist
This
review
aims
outline
involvement
glutamate
(GLU)
at
molecular
level
pathways
associated
with
demonstrate
target
therapeutic
potential
its
receptor.
We
will
also
consider
opinion
leading
authorities
working
this
area,
drawback
existing
strategies,
direction
further
investigation.
Язык: Английский