Effects of early, late and self-selected time-restricted eating on visceral adipose tissue and cardiometabolic health in participants with overweight or obesity: a randomized controlled trial
Nature Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Effects of a 12‐Week Mediterranean‐Type Time‐Restricted Feeding Protocol in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial—The ‘CHRONO‐NAFLD Project’
Alimentary Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
ABSTRACT
Background
The
Mediterranean
diet
(MD)
is
considered
the
best
dietary
approach
for
patients
with
metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD).
Recently,
time‐restricted
feeding
(TRF)
has
gained
attention
its
lifestyle
compatibility
and
health
benefits.
Aims
This
study
aimed
to
compare
effects
of
a
hypocaloric
MD
10‐h
TRF
protocol
an
unrestricted
in
MASLD
overweight/obesity
evaluate
differences
between
early
late
TRF.
Methods
12‐week
randomised
controlled
trial
consisted
three
groups,
all
following
Mediterranean‐type
diet.
control
group
had
no
eating
time
restrictions.
(eTRF)
(lTRF)
groups
window,
from
8
AM
6
PM
12
10
PM,
respectively.
Various
parameters
were
measured.
Compliance
was
tracked
via
food
diaries,
8‐week
follow‐up
occurred
post‐intervention.
Results
Fifty‐nine
individuals
(27
males;
52.9
years;
body
mass
index
32.1
kg/m
2
)
completed
(control,
n
=
19;
eTRF,
20;
lTRF,
20).
All
showed
significant
reductions
weight,
anthropometry
blood
pressure.
Glycated
haemoglobin
A
1c
insulin
resistance,
as
measured
by
Matsuda
index,
homeostatic
model
assessment
resistance
fasting
glucose‐to‐insulin
ratio,
improved
eTRF
at
weeks.
Conclusions
corroborates
efficacy
ameliorating
cardiometabolic
risk
factors
such
weight
pressure
patients.
combination
may
improve
glycaemic
(NCT05866744).
Trial
Registration
registered
clinicaltrials.gov
(NCT05866744)
Язык: Английский
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?
Current Obesity Reports,
Год журнала:
2025,
Номер
14(1)
Опубликована: Фев. 3, 2025
Язык: Английский
Efficacy of intermittent fasting on improving liver function in individuals with metabolic disorders: a systematic review and meta-analysis
Nutrition & Metabolism,
Год журнала:
2025,
Номер
22(1)
Опубликована: Янв. 6, 2025
Intermittent
fasting
(IF)
can
be
an
effective
dietary
therapy
for
weight
loss
and
improving
cardiometabolic
health.
However,
there
is
scant
evidence
regarding
the
role
of
IF
on
indicators
liver
function,
particularly
in
adults
with
metabolic
disorders.
Therefore,
we
performed
a
systematic
review
meta-analysis
to
investigate
effects
function
Three
primary
electronic
databases
including
PubMed,
Web
Science,
Scopus,
were
searched
from
inception
September
2024
identify
original
studies
that
used
interventions
or
without
control
groups
Inclusion
criteria
(1)
human
participants
diseases,
(2)
evaluated
IF,
(3)
group,
(4)
measured
fat,
steatosis,
fibrosis,
enzymes,
alanine
aminotransferase
(ALT)
aspartate
(AST)
as
outcomes.
Standardized
mean
differences
(SMD)
95%
confidence
intervals
calculated
using
random
models.
Heterogeneity
was
assessed
Cochran's
Q
statistic
I-squared
(I2).
Publication
bias
visual
inspection
funnel
plots
Egger's
tests.
The
risk
PEDro
scale
NIH
quality
assessment
tool.
A
total
21
involving
1,226
disorders
included
meta-analysis.
Overall,
effectively
decreased
fat
large
effect
size
[SMD:
-1.22
(95%
CI:
-1.63
-0.80),
p
=
0.001],
steatosis
medium
-0.73
-1.12
-0.35),
ALT
small
-0.44
-0.58
-0.30),
AST
-0.30
-0.49
-0.11),
but
not
fibrosis
-0.28
-0.59
0.02),
0.07].
Subgroup
analyses
showed
significantly,
independent
mode,
participant
age,
health
status,
intervention
duration.
significantly
those
obesity;
following
5:2
diets,
middle-aged
adults,
obesity,
regardless
status
seems
disorders,
many
function-related
benefits
occur
duration,
status.
Significant
heterogeneity,
numbers
inclusion
non-randomized
trials
single-group
pre-post
main
limitation
our
Further
randomized
clinical
are
needed
elucidate
Язык: Английский
Intermittent fasting is good for losing (some) weight
Nature Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Counting hours or calories? Metabolic regulatory role of time-restricted eating in adults with overweight and obesity: a systematic review and meta-analysis
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Июль 28, 2024
Time-restricted
eating
(TRE)
effectively
improves
healthspan,
including
controlling
obesity
and
improving
metabolic
health.
To
date,
few
meta-analyses
have
been
conducted
to
explore
the
effects
of
various
protocols
TRE
in
participants
with
overweight/obesity.
PubMed,
Embase
Cochrane
Central
Register
Controlled
Trials
were
searched
up
until
October
15,
2022.
Randomized
non-randomized
clinical
trials
that
investigated
effect
on
body
weight,
composition
cardiometabolic
parameters
overweight/obesity
included.
Mean
differences
changes
from
baseline
used
for
all
analyses
between
two
groups.
Prespecified
subgroup
based
different
performed.
Twenty-three
studies
included
meta-analysis
1867
participants.
interventions
led
significant
weight.
When
energy
restriction
strategies
both
control
groups,
weight-loss
remained
significant.
4
∼
8h
feeding
window,
morning
or
late
strategies,
reduction
weight
fat
mass
at
least
8
wk.
Hence
is
a
potential
effective
approach
loss
An
8h-TRE
intervention
strategy
eight
weeks
might
be
optimum
mode.
Язык: Английский