Diabetology, Год журнала: 2025, Номер 6(5), С. 43 - 43
Опубликована: Май 19, 2025
The global prevalence of obesity and type 2 diabetes has increased considerably in recent decades, primarily due to behavioral changes associated with societal progress, such as consumption high-calorie foods sedentary lifestyles. Obesity is a disease the energy homeostasis system, not merely passive accumulation fat. hypothalamus serves regulatory center for balance, together peripheral organs, liver, pancreas, muscle adipose tissue, controls food intake, expenditure, whole-body metabolism. Adenosine, product ATP catabolism, exerts its effects through various G-protein-coupled receptors: A1R, A2AR, A2BR, A3R. It plays key role regulating metabolism, including glucose homeostasis, insulin sensitivity, fat beta-oxidation, lipolysis tissue. Beyond roles CNS, adenosine receptors are also crucial metabolic tissues, where they regulate lipid contribute overall function. Several studies have been analyzing specifically regulation importance context diseases obesity. In this review, we provide an overview signaling highlighting well pathophysiological mechanisms underlying diabetes.
Язык: Английский