Abstract
Multicomponent
reactions
are
crucial
for
operating
organic
synthesis.
In
today's
world,
chemists
concentrate
on
greener
methodologies
that
cater
to
rising
environmental
concerns.
Most
conventional
solvents
harsh
the
environment,
which
can
be
addressed
by
environmentally
and
pocket‐friendly
Deep
eutectic
(DES).
Organic
synthesis
via
MCR
in
presence
of
DES
has
resulted
blend
green
methodology
solvent
transformations.
Forasmuch
as
addressing
concerns
developing
higher
heterocycles,
our
review
focuses
literature
published
DES‐mediated
N
‐Heterocyclic
compounds.
Molecules,
Год журнала:
2024,
Номер
29(13), С. 3089 - 3089
Опубликована: Июнь 28, 2024
Deep
eutectic
solvents
(DESs)
have
emerged
as
a
greener
alternative
to
other
more
polluting
traditional
and
attracted
lot
of
interest
in
the
last
two
decades.
The
DESs
are
less
toxic
dissolvents
lower
environmental
footprint.
This
paper
presents
an
synthesis
method
classical
heating–stirring
method.
ultrasound
is
one
most
promising
methods
for
terms
yield
energy
efficiency.
Therefore,
was
studied
obtain
hydrophobic
(Aliquat
336:L-Menthol
(3:7);
Lidocaine:Decanoic
acid
(1:2))
hydrophilic
based
on
choline
chloride,
urea,
ethylene
glycol
oxalic
acid.
physical
characterization
via
comparison
Fourier
transform
infrared
(FTIR)
spectra
showed
no
difference
between
obtained
by
methods.
study
all
prepared
were
carried
out
nuclear
magnetic
resonance
spectroscopy
(NMR).
density
viscosity
properties
evaluated.
values
similar
both
However,
differences
detected
due
presence
some
water
hygroscopic
DESs.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 3, 2025
A
novel
deep
eutectic
solvent
(ChCl/HGA-DES)
was
prepared
by
a
mixture
of
two
moles
choline
chloride
(ChCl)
and
one
mole
2,3-dihydroxybenzoic
acid
(hypogallic
acid,
HGA).
The
point
phase
diagram
showed
that
the
ChCl
HGA
is
best
molar
ratio
for
synthesizing
DES.
Then,
ChCl/HGA-DES
characterized
FT-IR,
TGA/DTA,
densitometer,
points,
1HNMR
techniques
used
as
capable
catalyst
green
synthesis
six
new
benzo[4,5]thiazolo[3,2-a]-
chromeno[4,3-d]pyrimidin-6-ones
5(a-f)
five
(2-(2-hydroxyphenyl)-8-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-3-yl)(morpholino)methanones
6(a-e)
through
one-pot
condensation
reactions.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2022,
Номер
10(37), С. 12165 - 12176
Опубликована: Сен. 6, 2022
Biobased
2,5-bis(hydroxymethyl)furan
is
a
versatile
building
block
for
the
production
of
drugs,
polymers,
crown
ethers,
bioactive
compounds,
and
value-added
intermediates.
To
explore
more
efficient
route
to
synthesize
2,5-bis(hydroxymethyl)furan,
tandem
transformation
by
quick
dehydration
with
deep
eutectic
solvent
betaine:benzenesulfonic
acid
(Bet:BSA)
mild
bioreduction
recombinant
Escherichia
coli
(E.
coli)
DCF
was
developed
converting
d-fructose
into
2,5-bis(hydroxymethyl)furan.
The
5-hydroxymethylfurfural
yield
reached
62.3
±
1.6%
(based
on
d-fructose)
in
Bet:BSA
at
120
°C
after
short
time
(2
min).
d-Fructose-valorized
biologically
transformed
newly
constructed
E.
containing
reductase
formate
dehydrogenase
40
pH
7.5
48
h,
99.6
0.1%
5-hydroxymethylfurfural)
Bet:BSA-water
cosubstrate
HCOONa
(5-HMF-to-HCOONa
molar
ratio,
1:2.5).
Meanwhile,
150
mM
commercial
94.4
0.9%.
An
hybrid
process
valorize
Bet:BSA-water,
which
has
good
industrial
application
potential.
RSC Sustainability,
Год журнала:
2024,
Номер
2(3), С. 578 - 607
Опубликована: Янв. 1, 2024
Journeying
towards
inherently
sustainable
and
green
synthetic
chemistry.
Commitment
to
change
(re)design
of
practices,
processes
goals,
through
reflection,
awareness
education.
Green Chemistry,
Год журнала:
2022,
Номер
24(9), С. 3629 - 3633
Опубликована: Янв. 1, 2022
A
NADES,
choline
chloride/water,
allows
a
high
yielding
preparation
of
pure
quinoxalines
embedding
acid
sensitive
and
other
functional
groups
at
room
temperature
in
very
short
reaction
time.
