Green Synthesis of Diphenyl‐Substituted Alcohols Via Radical Coupling of Aromatic Alcohols Under Transition‐Metal‐Free Conditions DOI Creative Commons
Ha V. Le, Vy T. Nguyen, Huy X. Le

и другие.

ChemistryOpen, Год журнала: 2024, Номер 13(12)

Опубликована: Авг. 22, 2024

Alcohols are common alkylating agents and starting materials alternative to harmful alkyl halides. In this study, a simple, benign efficient pathway was developed synthesize 1,3-diphenylpropan-1-ols via the β-alkylation of 1-phenylethanol with benzyl alcohols. Unlike conventional borrowing hydrogen processes in which alcohols were activated by transition-metal catalyzed dehydrogenation, work, t-BuONa suggested be dual-role reagent, namely, both base radical initiator, for coupling aromatic The cross-coupling reaction readily proceeded under transition metal-free conditions an inert atmosphere, affording 1,3-diphenylpropan-1-ol excellent yield. A good functional group tolerance observed, leading production various phenyl-substituted propan-1-ol derivatives moderate-to-good yields. mechanistic studies proposed that could involve formation reactive anions base-mediated deprotonation single electron transfer.

Язык: Английский

Green Synthesis of Diphenyl‐Substituted Alcohols Via Radical Coupling of Aromatic Alcohols Under Transition‐Metal‐Free Conditions DOI Creative Commons
Ha V. Le, Vy T. Nguyen, Huy X. Le

и другие.

ChemistryOpen, Год журнала: 2024, Номер 13(12)

Опубликована: Авг. 22, 2024

Alcohols are common alkylating agents and starting materials alternative to harmful alkyl halides. In this study, a simple, benign efficient pathway was developed synthesize 1,3-diphenylpropan-1-ols via the β-alkylation of 1-phenylethanol with benzyl alcohols. Unlike conventional borrowing hydrogen processes in which alcohols were activated by transition-metal catalyzed dehydrogenation, work, t-BuONa suggested be dual-role reagent, namely, both base radical initiator, for coupling aromatic The cross-coupling reaction readily proceeded under transition metal-free conditions an inert atmosphere, affording 1,3-diphenylpropan-1-ol excellent yield. A good functional group tolerance observed, leading production various phenyl-substituted propan-1-ol derivatives moderate-to-good yields. mechanistic studies proposed that could involve formation reactive anions base-mediated deprotonation single electron transfer.

Язык: Английский

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