Proceedings of the National Academy of Sciences,
Год журнала:
2020,
Номер
117(41), С. 25560 - 25570
Опубликована: Сен. 28, 2020
Significance
Deregulated
global
mRNA
translation
is
a
feature
of
various
cancers
and
considered
important
in
oncogenic
transformation.
In
colorectal
cancer
(CRC),
the
role
most
common
driver
mutations
APC
,
KRAS
SMAD4
TP53
on
translational
capacity
are
incompletely
understood.
Here,
using
mouse
human
intestinal
organoids,
we
found
that
each
mutation
governs
epithelial
cell.
Global
linked
to
known
hallmarks,
including
cell
proliferation
growth
upon
accumulation
these
mutations,
posing
apparatus
as
potential
therapeutic
target
CRC.
Colorectal
cancer
(CRC)
leads
to
significant
morbidity/mortality
worldwide.
Defining
critical
research
gaps
(RG),
their
prioritisation
and
resolution,
could
improve
patient
outcomes.
Frontiers in Cell and Developmental Biology,
Год журнала:
2018,
Номер
6
Опубликована: Июнь 12, 2018
Historically,
the
link
between
chronic
inflammation
and
cancer
has
long
been
speculated.
Only
more
recently,
pre-clinical
epidemiologic
data
as
well
clinical
evidence
all
point
to
role
of
tumor
microenvironment
inextricably
connected
neoplastic
process.
The
(TME),
a
complex
mix
vasculature,
inflammatory
cells,
stromal
cells
is
essential
"soil"
helping
modulate
potential.
Increasingly,
suggests
that
modifies
microenvironment,
via
host
mechanisms,
including
production
cytokines,
pro-inflammatory
mediators,
angiogenesis,
tissue
remodeling.
Inflammation
can
be
triggered
by
variety
different
pressures,
such
carcinogen
exposure,
immune
dysfunction,
dietary
habits
obesity,
genetic
alterations
leading
oncogene
activation
or
loss
suppressors.
In
this
review,
we
examine
concept
related
both
extrinsic
intrinsic
stimuli
promote
in
turn
tumorigenesis.
Understanding
common
pathways
inherent
an
response
may
shed
light
on
new
therapies
for
primary
metastatic
disease.
personalized
medicine
pushed
field
oncology
drill
down
changes
cancer,
hopes
identifying
individually
targeted
agents.
Given
complexities
it
clear
effective
oncologic
will
necessitate
targeting
not
only
but
their
dynamic
relationship
well.
WIREs Mechanisms of Disease,
Год журнала:
2020,
Номер
13(3)
Опубликована: Окт. 21, 2020
Abstract
β‐catenin‐mediated
Wnt
signaling
is
an
ancient
cell‐communication
pathway
in
which
β‐catenin
drives
the
expression
of
certain
genes
as
a
consequence
trigger
given
by
extracellular
WNT
molecules.
The
events
occurring
from
signal
to
transcription
are
evolutionarily
conserved,
and
their
final
output
orchestrates
countless
processes
during
embryonic
development
tissue
homeostasis.
Importantly,
dysfunctional
Wnt/β‐catenin
causes
developmental
malformations,
its
aberrant
activation
root
several
types
cancer.
A
rich
literature
describes
multitude
nuclear
players
that
cooperate
with
generate
transcriptional
program.
However,
unified
theory
how
target
gene
still
missing.
We
will
discuss
two
interactors:
factors
allow
localize
at
regions
on
DNA,
co‐factors
ultimately
activate
expression.
In
contrast
presumed
universality
β‐catenin's
action,
ensemble
available
evidence
suggests
view
complex
system
responses
different
cells
tissues.
malleable
armamentarium
might
interact
order
right
“canonical”
targets
each
tissue,
stage,
or
disease
context.
Discovering
mechanism
tissue‐specific
response
executed
be
crucial
comprehend
seemingly
universal
fosters
wide
spectrum
Perhaps
more
importantly,
this
could
inform
us
about
tumor‐specific
components
need
targeted
dampen
activity
oncogenic
β‐catenin.
This
article
categorized
under:
Cancer
>
Molecular
Cellular
Physiology
Genetics/Genomics/Epigenetics
Stem
Cells
Development
Journal of Cellular and Molecular Medicine,
Год журнала:
2020,
Номер
24(4), С. 2648 - 2662
Опубликована: Янв. 19, 2020
Abstract
High‐fat
diet
(HFD)
is
a
well‐known
risk
factor
for
gut
microbiota
dysbiosis
and
colorectal
cancer
(CRC).
However,
evidence
relating
HFD,
carcinogenesis
limited.
Our
study
aimed
to
demonstrate
that
HFD‐induced
promoted
intestinal
adenoma‐adenocarcinoma
sequence.
In
clinical
study,
we
found
HFD
increased
the
incidence
of
advanced
neoplasia
(AN).
The
expression
monocyte
chemoattractant
protein
1
(MCP‐1),
CC
chemokine
receptor
2
(CCR2)
CD163
in
CRC
patients
with
was
significantly
higher
than
normal
diet.
When
it
comes
Apc
min/+
mice,
consumption
could
induce
promote
carcinogenesis,
accompanying
activation
MCP‐1/CCR2
axis
recruited
polarized
M2
tumour‐associated
macrophages.
Interestingly,
transfer
faecal
from
HFD‐fed
mice
another
batch
absence
also
enhance
without
significant
body
weight
gain
induced
activation.
be
transmitted.
Meanwhile,
antibiotics
cocktail
treatment
sufficient
inhibit
indicating
vital
role
development.
Conclusively,
these
data
indicated
accelerated
sequence
through
axis,
which
would
provide
new
insight
into
better
understanding
mechanisms
prevention
HFD‐related
CRC.
Proceedings of the National Academy of Sciences,
Год журнала:
2020,
Номер
117(41), С. 25560 - 25570
Опубликована: Сен. 28, 2020
Significance
Deregulated
global
mRNA
translation
is
a
feature
of
various
cancers
and
considered
important
in
oncogenic
transformation.
In
colorectal
cancer
(CRC),
the
role
most
common
driver
mutations
APC
,
KRAS
SMAD4
TP53
on
translational
capacity
are
incompletely
understood.
Here,
using
mouse
human
intestinal
organoids,
we
found
that
each
mutation
governs
epithelial
cell.
Global
linked
to
known
hallmarks,
including
cell
proliferation
growth
upon
accumulation
these
mutations,
posing
apparatus
as
potential
therapeutic
target
CRC.
