Health-Related Quality of Life and Functional Status of Post-COVID-19 Patients DOI Open Access
Miriã Cândida Oliveira,

Larissa R. Alves,

Juliana Soares

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(3), С. 338 - 338

Опубликована: Фев. 25, 2025

COVID-19 mainly affects the respiratory system, although its manifestations are multisystemic. We increasingly recognizing complications that present after acute phase, which associated with impaired functional status and health-related quality of life (HRQoL). The objective was to assess HRQoL patients post-COVID-19. This a cross-sectional study involving individuals affected by who had persistent symptoms for one month phase disease. Functional measured six-minute walk test (6MWT), Fatigue Severity Scale (FSS), Medical Research Council (MRC) Dyspnea Scale, Post-COVID-19 Status (PCFS). confirmed Short-Form Health Survey 36 (SF-36). included 123 patients; 73 (59.35%) were male, mean age 49.17 ± 13.48 years body mass index 31.02 6.56 stratified into three groups: not-recovered group (NRG = 23), ward-recovered (WHG 60), intensive-care-unit (ICUG 40). main muscle weakness (74.17%) dyspnea (68.33%). predicted distances 6MWT missed 12.83% GNR group, 20.21% 28.82% UGCI group. MRC scale value less than 3, FSS over 4, indicating considerable fatigue. In PCFS scale, significant difference observed (p < 0.0005), while in SF-36, all domains compromised. involved this showed decline an impairment HRQoL.

Язык: Английский

“Post Coronavirus Disease (COVID-19) Reactivation of a Quiescent Unilateral Anterior Uveitis” DOI Creative Commons
Srinivasan Sanjay,

Deepashri Mutalik,

Sunil Gowda

и другие.

SN Comprehensive Clinical Medicine, Год журнала: 2021, Номер 3(9), С. 1843 - 1847

Опубликована: Июнь 7, 2021

Язык: Английский

Процитировано

29
Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2 DOI Creative Commons
Yen‐Chung Lai, Yuwei Cheng, Chiao-Hsuan Chao

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Май 4, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus responsible for the ongoing COVID-19 pandemic. SARS-CoV-2 binds to human cell receptor angiotensin-converting enzyme (ACE2) through its receptor-binding domain in S1 subunit of spike protein (S1-RBD). The serum levels autoantibodies against ACE2 are significantly higher patients with than controls and associated disease severity. However, mechanisms which these anti-ACE2 antibodies induced during infection unclear. In this study, we confirmed increase found a positive correlation between amounts S1-RBD. Moreover, antibody binding was decreased sera some after preadsorption S1-RBD, indicated that S1-RBD can cross-react ACE2. To confirm possibility, two monoclonal (mAbs 127 150) could bind both were isolated from S1-RBD-immunized mice. Measurement affinities by Biacore showed mAbs much weaker Epitope mapping using synthetic overlapping peptides hydrogen deuterium exchange mass spectrometry (HDX-MS) revealed amino acid residues P463, F464, E465, R466, D467 E471 critical recognition 150. addition, Western blotting analysis recognize only native but not denatured form, indicating epitopes recognized conformation-dependent. protein-protein interaction affinity mAb analyzed HDX-MS visualized negative-stain transmission electron microscopy imaging combined antigen-antibody docking. Together, our results suggest ACE2-cross-reactive anti-S1-RBD be due potential antigenic cross-reactivity

Язык: Английский

Процитировано

21
COVID-19 reduces cardiorespiratory fitness even months after a mild to moderate acute phase: a retrospective cohort study DOI
Ladislav Štěpánek, Marie Nakládalová, Eliška Sovová

и другие.

Infectious Diseases, Год журнала: 2023, Номер 55(10), С. 684 - 693

Опубликована: Июль 3, 2023

Background COVID-19 survivors may experience long-term health problems, including deterioration of cardiorespiratory fitness (CRF), as demonstrated by several cross-sectional studies that compared the results cardiopulmonary exercise tests (CPET) performed only after with predicted values. This study aimed to analyze a change in CRF between repeated CPETs response suffered COVID-19.Methods A total 127 healthcare workers (HCWs; mean age 55.7 years) underwent two interval 762 days. Forty HCWs from (mild moderate severity) interim (321 days before second CPET), and 87 formed control group. Mixed-effects regression multiple adjustment interaction terms was used for variables – maximum oxygen uptake (VO2 max) power output.Results Between both CPETs, VO2 max decreased statistically significantly subgroup (by 3.12 mL/kg/min, p = .034) insignificantly controls 0.56 .412). The proportion achieving 75.9% 59.5% (p .161) survivors, while it increased 73.8% 81% .274) controls. (β −0.66, .014) body mass index −0.49, < .001) were independent negative predictors change. not associated output.Conclusions On basis significantly, albeit rather modestly, reduces almost one year infection. reduction persists even acute phase mild or severity.

Язык: Английский

Процитировано

12
The Coming of Age of the P2X7 Receptor in Diagnostic Medicine DOI Open Access
Francesco Di Virgilio, Valentina Vultaggio-Poma, Simonetta Falzoni

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(11), С. 9465 - 9465

Опубликована: Май 30, 2023

The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its cloning, and identification role a multiplicity immune-mediated diseases raised great hopes for development novel more potent anti-inflammatory medicaments. Unfortunately, such were partially deluded by unsatisfactory results most early clinical trials. This failure substantially reduced interest pharmaceutical biotech industries P2X7R-targeted therapies. However, recent findings ushered second life P2X7R diagnostic medicine. New radioligands proved to be very reliable tools diagnosis neuroinflammation preclinical studies, detection measurement free (or subunit) human blood suggested potential use as circulating marker inflammation. Here we provide brief review these developments.

Язык: Английский

Процитировано

11
Health-Related Quality of Life and Functional Status of Post-COVID-19 Patients DOI Open Access
Miriã Cândida Oliveira,

Larissa R. Alves,

Juliana Soares

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(3), С. 338 - 338

Опубликована: Фев. 25, 2025

COVID-19 mainly affects the respiratory system, although its manifestations are multisystemic. We increasingly recognizing complications that present after acute phase, which associated with impaired functional status and health-related quality of life (HRQoL). The objective was to assess HRQoL patients post-COVID-19. This a cross-sectional study involving individuals affected by who had persistent symptoms for one month phase disease. Functional measured six-minute walk test (6MWT), Fatigue Severity Scale (FSS), Medical Research Council (MRC) Dyspnea Scale, Post-COVID-19 Status (PCFS). confirmed Short-Form Health Survey 36 (SF-36). included 123 patients; 73 (59.35%) were male, mean age 49.17 ± 13.48 years body mass index 31.02 6.56 stratified into three groups: not-recovered group (NRG = 23), ward-recovered (WHG 60), intensive-care-unit (ICUG 40). main muscle weakness (74.17%) dyspnea (68.33%). predicted distances 6MWT missed 12.83% GNR group, 20.21% 28.82% UGCI group. MRC scale value less than 3, FSS over 4, indicating considerable fatigue. In PCFS scale, significant difference observed (p < 0.0005), while in SF-36, all domains compromised. involved this showed decline an impairment HRQoL.

Язык: Английский

Процитировано

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