Russian Journal of Organic Chemistry, Год журнала: 2024, Номер 60(11), С. 2266 - 2275
Опубликована: Ноя. 1, 2024
Язык: Английский
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
3
Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(2)
Опубликована: Март 1, 2025
The global obesity epidemic has heightened interest in natural solutions, with anti-obesity peptides emerging as promising candidates. Derived from food sources such plants, algae, marine organisms, and products like milk eggs, these combat through various mechanisms but face challenges production scalability. aim of this review is to explore their sources, mechanisms, measurement, synthesis methods, including innovative approaches de novo synthesis, proteomics, bioinformatics. Its unique contribution lies critically analyzing the current state research while highlighting novel techniques practical relevance addressing commercialization challenges, offering valuable insights for advancing peptide development. Diverse methods assessing properties are discussed, encompassing both vitro vivo experimental approaches, well alternatives. also explores integration cutting-edge technologies potential revolutionize scalability cost-effectiveness. Key findings assert that despite great fight against advances identification analysis, scalability, regulatory hurdles, bioavailability issues, high costs, consumer appeal persist. Future should use bioinformatics tools advanced screening identify design enhanced efficacy bioavailability, efficient cost-effective extraction purification sustainable practices utilizing byproducts industry, containing isolated versus whole materials clinical settings.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 397 - 397
Опубликована: Март 21, 2025
Peptide and protein (PP) therapeutics are highly specific potent biomolecules that treat chronic complex diseases. However, their oral delivery is significantly hindered by enzymatic degradation, instability, poor permeability through the gastrointestinal (GI) epithelium, resulting in low bioavailability. Various strategies have emerged as transformative solutions to address existing challenges, offering enhanced protection, stabilization, absorption of PPs. These primarily focus on two major challenges: protecting PP against harsh conditions enhancing permeation across intestinal membrane. Innovative approaches such pH modulation incorporation enzyme inhibitors usually used mitigate proteolytic degradation during transit GI tract. In a similar vein, enhancers prodrug facilitate epithelial transport, while targeted systems areas tract enhance absorption. Likewise, mucus-penetrating mucoadhesive retention interaction with cells, effectively overcoming barriers like mucus layer tight junctions. Furthermore, structural modifications lipidation, peptide cyclization, polyethylene glycosylation promising alternatives render stability, prolong circulation time, membrane permeability. particular, functional biomaterials, active targeting, lymphatic transport provided new platforms for delivery. Advancing materials science, nanotechnology, disruption medical devices holds frontiers overcome barriers. Despite substantial advancements, limited success clinical translation underscores urgency innovative strategies. This review presents PPs platform, highlighting key transform therapeutic landscapes.
Язык: Английский
Процитировано
0
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117534 - 117534
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111783 - 111783
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
RSC Advances, Год журнала: 2024, Номер 14(54), С. 39968 - 39976
Опубликована: Янв. 1, 2024
Synthesis of small peptides using DCC and HOBt in H 2 O–THF.
Язык: Английский
Процитировано
1
Organic Process Research & Development, Год журнала: 2024, Номер 28(8), С. 3347 - 3367
Опубликована: Июль 25, 2024
While numerous studies aimed at producing peptides in a sustainable manner have recently been reported, the impact of quality starting materials on sustainability peptide synthesis has less investigated. Here we report that NBP, greener dipolar aprotic solvent suitable for use SPPS, readily undergoes air oxidation to corresponding hydroperoxide (NBP-OOH), which adversely affects oxidation-sensitive amino acids and peptides. Air, light, elevated temperatures, common reagents such as DIC accelerated rate NBP oxidation. LC-HRMS analyses revealed air-induced degradation proceeds via different mechanism than previously elucidated closely related NMP while GC–MS containing NBP-OOH showed standard GC-based analytical methods are unsuitable detection, warranting implementation improved analyses. Assessment NBP-OOH-induced Met, Trp, Cys, Tyr breakdown not only degrades all these oxidation-prone substrates, but it was also discovered DITU, reported suppress N-oxyl radical-induced breakdown, constitutes an efficient suppressant hydroperoxide-induced degradation. Studies aerial additional solvents DMSO DMPU former is stable does cause oxidation, latter oxidized extensively upon exposure substrates significant extent. On other hand, bubbling DMSO, proved unexpected positive effect stability α-amino-bound Fmoc group, finding may be leveraged minimize premature loss during synthesis. Overall, our understanding mitigating formation illustrate importance thorough assessment development synthetic methods.
Язык: Английский
Процитировано
0
Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2024, Номер 3(4), С. 54 - 68
Опубликована: Авг. 25, 2024
Current advances in knowledge about peptides as drugs are of great significance; They have planning potentialities different sections medicinal practice. This review will summarize the progress synthesis and biological activities peptide-based drug, along with some uses. We start historical aspect key points development corresponding field. In general, part describes approaches synthesis, design strategies, screening methods, optimization for stability bioavailability. then describe action such mechanisms respect to receptors, enzymes, that can penetrate cells. It has also expanded assessment description peptide treatment cancer, cardiovascular diseases, metabolic neurological infectious immunotherapy. cover both problems formation like stability, delivery, regulatory issues opportunities nanotechnology, bioprinting, CRISPR. Last, we discuss outlook therapeutics features, which promising new trends perspectives application. The present is intended give an up-to-date easy grasp information regarding status peptide-associated medicines contemporary pharmacology.
Язык: Английский
Процитировано
0
Russian Journal of Organic Chemistry, Год журнала: 2024, Номер 60(11), С. 2266 - 2275
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0