Safety and Toxicology of Cannabinoids DOI Creative Commons

Jane Sachs,

Erin McGlade, Deborah Yurgelun‐Todd

и другие.

Neurotherapeutics, Год журнала: 2015, Номер 12(4), С. 735 - 746

Опубликована: Авг. 12, 2015

There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate medical recreational cannabis policies at state federal levels. This review will include a brief description cannabinoids endocannabinoid system; summary acute long-term effects cannabis; discussion The conclusions about safety efficacy then be compared with current social political climate to suggest future policy directions general guidelines.

Язык: Английский

Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling DOI
G Grabner, Robert Zimmermann, Rudolf Schicho

и другие.

Pharmacology & Therapeutics, Год журнала: 2017, Номер 175, С. 35 - 46

Опубликована: Фев. 15, 2017

Язык: Английский

Процитировано

123

Terpenes and derivatives as a new perspective for pain treatment: a patent review DOI
Adriana Gibara Guimarães, Mairim Russo Serafini, Lucindo José Quintans‐Júnior

и другие.

Expert Opinion on Therapeutic Patents, Год журнала: 2014, Номер 24(3), С. 243 - 265

Опубликована: Янв. 6, 2014

Introduction: Terpenes are natural compounds found in several organisms belonging to the animal and plant kingdoms. They constitute largest class of products with > 55,000 known structurally diversified. Several studies have attributed this big family a range pharmacological properties, such as anticancer, antimicrobial, antifungal, antiviral, antihyperglycemic, analgesic, anti-inflammatory antiparasitic. Areas covered: In review, authors summarize therapeutic patent applications concerning employment terpenes for pain relief, focusing on perspective these become candidates new drugs intended control painful syndromes. Expert opinion: Over years tremendous academic industrial investment characterization analgesic action terpenes, there was development successful product that has been well-accepted clinically. Furthermore, is still hope options syndromes will be developed from which shown great purpose because mechanisms important target sites.

Язык: Английский

Процитировано

122

Characterizing the Followers and Tweets of a Marijuana-Focused Twitter Handle DOI Creative Commons
Patricia Cavazos‐Rehg, Melissa J. Krauss, Richard A. Grucza

и другие.

Journal of Medical Internet Research, Год журнала: 2014, Номер 16(6), С. e157 - e157

Опубликована: Июнь 27, 2014

Background: Twitter is a popular social media forum for sharing personal experiences, interests, and opinions. An improved understanding of the discourse on that encourages marijuana use can be helpful tailoring targeting online offline prevention messages. Objectives: The intent study was to assess content "tweets" demographics followers pro-marijuana handle (@stillblazingtho). Methods: We assessed sentiment tweets (sent from May 1 December 31, 2013), as well consumers follow (approximately 1,000,000 followers) using analytics Demographics Pro. This company estimates demographic characteristics based behavior/usage, relying multiple data signals networks, consumption, language requires confidence 95% or above make an estimate single characteristic. Results: A total 2590 were sent @stillblazingtho during 8-month period 305 (11.78%) replies another user excluded qualitative analysis. Of remaining 2285 tweets, 1875 (82.06%) positive about marijuana, 403 (17.64%) neutral, 7 (0.31%) appeared negative marijuana. Approximately 1101 (58.72%) perceived jokes humorous, 340 (18.13%) implied helps you feel good relax, 294 (15.68%) mentioned routine, frequent, heavy use, 193 (10.29%) blunts, edibles, paraphernalia (eg, bongs, vaporizers), 186 (9.92%) other risky health behaviors tobacco, alcohol, drugs, sex). majority (699,103/959,143; 72.89%) 19 years old younger. Among people ages 17 years, in top 10% all handles followed. More United States African American (323,107/759,407; 42.55%) Hispanic (90,732/759,407; 11.95%) than median average (African 22.4%, inter-quartile ratio [IQR] 5.1-62.5%; 5.4%, IQR 3.0-10.8%) among Hispanics, 30% Conclusions: Young are especially responsive influences often establish substance patterns this phase development. Our findings underscore need surveillance efforts monitor reaching young Twitter.

Язык: Английский

Процитировано

118

The effects of cannabinoid administration on sleep: a systematic review of human studies DOI
Peter Gates, Lucy Albertella, Jan Copeland

и другие.

Sleep Medicine Reviews, Год журнала: 2014, Номер 18(6), С. 477 - 487

Опубликована: Март 9, 2014

Язык: Английский

Процитировано

117

Safety and Toxicology of Cannabinoids DOI Creative Commons

Jane Sachs,

Erin McGlade, Deborah Yurgelun‐Todd

и другие.

Neurotherapeutics, Год журнала: 2015, Номер 12(4), С. 735 - 746

Опубликована: Авг. 12, 2015

There is extensive research on the safety, toxicology, potency, and therapeutic potential of cannabis. However, uncertainty remains facilitating continued debate medical recreational cannabis policies at state federal levels. This review will include a brief description cannabinoids endocannabinoid system; summary acute long-term effects cannabis; discussion The conclusions about safety efficacy then be compared with current social political climate to suggest future policy directions general guidelines.

Язык: Английский

Процитировано

116