Behind the Curtain of Abnormal Placentation in Pre-Eclampsia: From Molecular Mechanisms to Histological Hallmarks

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7886 - 7886

Опубликована: Июль 18, 2024

Successful human pregnancy needs several highly controlled steps to guarantee an oocyte’s fertilization, the embryo’s pre-implantation development, and its subsequent implantation into uterine wall. The placenta development ensures adequate fetal nutrition oxygenation, with trophoblast being first cell lineage differentiate during this process. sustains growth of fetus by providing it oxygen nutrients removing waste products. It is not surprising that issues early can lead common disorders, such as recurrent miscarriage, restriction, pre-eclampsia, stillbirth. Understanding normal essential for recognizing contextualizing any pathological aberrations may occur. effects these become apparent until later in pregnancy, mid or advanced stages. This review discusses process embryo phase, molecular mechanisms involved, abnormalities those are thought contribute pre-eclampsia. also covers histological hallmarks pre-eclampsia found examination placental tissue from patients.

Язык: Английский

Extracellular vesicles—An omics view

PROTEOMICS, Год журнала: 2024, Номер 24(11)

Опубликована: Апрель 26, 2024