Briefings in Bioinformatics,
Год журнала:
2024,
Номер
25(2)
Опубликована: Янв. 22, 2024
Abstract
Lysine
lactylation
(Kla)
is
a
newly
discovered
posttranslational
modification
that
involved
in
important
life
activities,
such
as
glycolysis-related
cell
function,
macrophage
polarization
and
nervous
system
regulation,
has
received
widespread
attention
due
to
the
Warburg
effect
tumor
cells.
In
this
work,
we
first
design
natural
language
processing
method
automatically
extract
3D
structural
features
of
Kla
sites,
avoiding
potential
biases
caused
by
manually
designed
features.
Then,
establish
two
prediction
frameworks,
Attention-based
feature
fusion
model
(ABFF-Kla)
EBFF-Kla,
integrate
sequence
structure
based
on
layer
embedding
layer,
respectively.
The
results
indicate
ABFF-Kla
Embedding-based
(EBFF-Kla),
which
fuse
from
protein
sequences
spatial
structures,
have
better
predictive
performance
than
models
use
only
Our
work
provides
an
approach
for
automatic
extraction
features,
well
flexible
framework
prediction.
source
code
training
data
EBFF-Kla
are
publicly
deposited
at:
https://github.com/ispotato/Lactylation_model.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Фев. 5, 2024
Abstract
For
decades,
lactate
has
been
considered
a
byproduct
of
glycolysis.
The
shuttle
hypothesis
shifted
the
paradigm,
demonstrating
that
not
only
plays
important
roles
in
cellular
metabolism
but
also
communications,
which
can
transcend
compartment
barriers
and
occur
within
among
different
cells,
tissues
organs.
Recently,
discovery
induce
novel
post-translational
modification,
named
lysine
lactylation
(Kla),
brings
forth
new
avenue
to
study
nonmetabolic
functions
for
lactate,
inspired
‘gold
rush’
academic
commercial
interest.
Zhang
et
al.
first
showed
Kla
is
manifested
histones
as
epigenetic
marks,
then
mounting
evidences
demonstrated
occurs
diverse
non-histone
proteins.
widespread
faithfully
orchestrates
numerous
biological
processes,
such
transcription,
inflammatory
responses.
Notably,
dysregulation
touches
myriad
pathological
processes.
In
this
review,
we
comprehensively
reviewed
curated
existing
literature
retrieve
identified
sites
on
both
proteins
summarized
recent
major
advances
toward
its
regulatory
mechanism.
We
thoroughly
investigated
function
underlying
signaling
pathway
summarize
how
regulates
various
processes
normal
physiological
states.
addition,
further
highlight
effects
development
human
diseases
including
inflammation
response,
tumorigenesis,
cardiovascular
nervous
system
other
complex
diseases,
might
potentially
contribute
deeply
understanding
interpreting
mechanism
pathogenicity.
Graphical
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Сен. 16, 2024
Abstract
Histone
post-translational
modifications
(HPTMs),
as
one
of
the
core
mechanisms
epigenetic
regulation,
are
garnering
increasing
attention
due
to
their
close
association
with
onset
and
progression
diseases
potential
targeted
therapeutic
agents.
Advances
in
high-throughput
molecular
tools
abundance
bioinformatics
data
have
led
discovery
novel
HPTMs
which
similarly
affect
gene
expression,
metabolism,
chromatin
structure.
Furthermore,
a
growing
body
research
has
demonstrated
that
histone
also
play
crucial
roles
development
various
diseases,
including
cancers,
cardiovascular
infectious
psychiatric
disorders,
reproductive
system
diseases.
This
review
defines
nine
modifications:
lactylation,
citrullination,
crotonylation,
succinylation,
SUMOylation,
propionylation,
butyrylation,
2-hydroxyisobutyrylation,
2-hydroxybutyrylation.
It
comprehensively
introduces
modification
processes
these
HPTMs,
transcription,
replication,
DNA
repair
recombination,
structure,
well
involvement
promoting
occurrence
clinical
applications
targets
biomarkers.
Moreover,
this
provides
detailed
overview
HPTM
inhibitors
targeting
emerging
strategies
treatment
multiple
while
offering
insights
into
future
prospects
challenges.
Additionally,
we
briefly
introduce
techniques
field
research.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 27, 2023
As
a
major
product
of
glycolysis
and
vital
signaling
molecule,
many
studies
have
reported
the
key
role
lactate
in
tumor
progression
cell
fate
determination.
Lactylation
is
newly
discovered
post-translational
modification
induced
by
lactate.
On
one
hand,
lactylation
introduced
new
era
metabolism
microenvironment
(TME),
on
other
it
provided
breakthrough
point
for
elucidation
interaction
between
metabolic
reprogramming
epigenetic
modification.
Studies
shown
that
cells,
stem
cells
tumor-infiltrating
immune
TME
can
participate
development
cancer
through
downstream
transcriptional
regulation,
potential
promising
treatment
target.
This
review
summarized
discovery
effects
lactylation,
as
well
recent
research
histone
regulating
reshaping
TME.
We
also
focused
strategies
to
enhance
anti-tumor
via
targeting
lactylation.
Finally,
we
discussed
limitations
existing
proposed
perspectives
future
order
further
explore
targets.
It
may
provide
way
direction
improve
prognosis.
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
ABSTRACT
In
recent
years,
a
significant
breakthrough
has
emerged
in
biology,
the
identification
of
lactylation,
novel
post‐translational
process.
This
intriguing
modification
is
not
limited
to
specific
class
proteins
but
occurs
across
diverse
range,
including
histones,
signalling
molecules,
enzymes,
and
substrates.
It
can
exert
broad
regulatory
role
various
diseases,
ranging
from
developmental
anomalies
neurodegenerative
disorders
inflammation
cancer.
Thus,
it
presents
exciting
opportunities
for
exploring
innovative
treatment
approaches.
As
result,
there
been
surge
research
interest,
leading
deeper
understanding
molecular
mechanisms
functions
underlying
lactylation
within
physiological
pathological
processes.
Here,
we
review
detection
biological
disease
effects,
providing
systematic
overview
this
modification.
Life Sciences,
Год журнала:
2024,
Номер
342, С. 122540 - 122540
Опубликована: Фев. 29, 2024
Transcatheter
arterial
chemoembolisation
(TACE)
is
the
standard
of
care
for
intermediate-stage
hepatocellular
carcinoma
and
selected
patients
with
advanced
carcinoma.
However,
TACE
does
not
achieve
a
satisfactory
objective
response
rate,
concept
refractoriness
has
been
proposed
to
identify
who
do
fully
benefit
from
TACE.
Moreover,
repeated
necessary
obtain
an
optimal
sustained
anti-tumour
response,
which
may
damage
patient's
liver
function.
Therefore,
studies
have
recently
performed
improve
effectiveness
In
this
review,
we
summarise
detailed
molecular
mechanisms
associated
responsiveness
relapse
after
treatment
provide
more
effective
targets
adjuvant
therapy
while
helping
regimens.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 4, 2024
Lactylation
is
a
process
where
lactate,
cellular
metabolism
byproduct,
added
to
proteins,
altering
their
functions.
In
the
realm
of
macrophage
activation,
lactylation
impacts
inflammatory
response
and
immune
regulation.
Understanding
effects
on
activation
vital
in
lung
diseases,
as
abnormal
function
are
pivotal
conditions
like
pneumonia,
pulmonary
fibrosis,
COPD,
cancer.
This
review
explores
concept
lactylation,
its
regulation
recent
research
progress
diseases.
It
offers
new
insights
into
disease
pathogenesis
potential
therapeutic
targets.
Lactylation,
a
post-translational
modification,
is
increasingly
recognized
for
its
role
in
cancer
progression.
This
study
investigates
prevalence
and
impact
oral
squamous
cell
carcinoma
(OSCC).
