Three-Dimensional Printable Magnetic Hydrogels with Adjustable Stiffness and Adhesion for Magnetic Actuation and Magnetic Hyperthermia Applications
Xueting Xuan,
Yi Li,
Xing Xu
и другие.
Gels,
Год журнала:
2025,
Номер
11(1), С. 67 - 67
Опубликована: Янв. 15, 2025
Stimuli-responsive
hydrogels
hold
immense
promise
for
biomedical
applications,
but
conventional
gelation
processes
often
struggle
to
achieve
the
precision
and
complexity
required
advanced
functionalities
such
as
soft
robotics,
targeted
drug
delivery,
tissue
engineering.
This
study
introduces
a
class
of
3D-printable
magnetic
with
tunable
stiffness,
adhesion,
responsiveness,
prepared
through
simple
efficient
“one-pot”
method.
approach
enables
precise
control
over
hydrogel’s
mechanical
properties,
an
elastic
modulus
ranging
from
43
kPa
277
kPa,
tensile
strength
93
421
toughness
243
kJ/m3
1400
kJ/m3,
achieved
by
modulating
concentrations
acrylamide
(AM)
Fe3O4
nanoparticles.
These
exhibit
rapid
heating
under
alternating
field,
reaching
44.4
°C
within
600
s
at
15
wt%,
demonstrating
potential
use
in
mild
hyperthermia.
Furthermore,
integration
nanoparticles
nanoclay
into
AM
precursor
optimizes
rheological
properties
ensures
high
printability,
enabling
fabrication
complex,
high-fidelity
structures
extrusion-based
3D
printing.
Compared
existing
hydrogels,
our
platform
uniquely
combines
adjustable
strong
multifunctionality,
offering
enhanced
capabilities
actuation
hyperthermia
applications.
advancement
marks
significant
step
toward
scalable
production
next-generation
intelligent
medicine
bioengineering.
Язык: Английский
Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
Abstract
Inflammatory
bowel
disease
(IBD)
is
a
complex
chronic
inflammatory
disorder
of
the
gastrointestinal
(GI)
tract
with
an
uncertain
etiology.
Currently,
IBD
therapy
relies
on
induction
clinical
remission
followed
by
maintenance
using
anti‐inflammatory
drugs
and
immunosuppressants;
however,
definite
cure
still
out
scope.
Established
approaches
are
characterized
adverse
drug‐related
side
effects
that
can
even
be
potentially
life‐threatening.
In
contrast,
increased
interest
remarkable
scientific
progress
in
targeted
drug
delivery
systems
offer
promising
approach
to
reduce
systemic
events,
delivering
therapeutic
substances
only
inflamed
tissue.
All
alteration
barrier
integrity,
especially
disturbed
epithelial
barrier,
unique
pattern
receptors
cell
surface
and/or
oxidative
stress
milieu
areas
used
as
effective
for
controlled
delivery.
Hence,
this
review
focuses
pathophysiology
GI
potential
strategy
polymeric
nanoparticles
treatment.
Interdisciplinary
efforts
between
chemistry
gastroenterology/immunology
promise
create
novel
synergies
improve
development
nanoparticle
significant
impact.
regard,
current
challenges
translation
nanomedicine
also
discussed.
Язык: Английский
Transdermal anti-inflammatory effects and mechanisms of hydrogel patches containing seco-iridoids from Gentiana macrophylla Pall
Fitoterapia,
Год журнала:
2025,
Номер
183, С. 106544 - 106544
Опубликована: Апрель 15, 2025
Язык: Английский
Mussel‐inspired stretchable, anti‐fatigue, self‐healing and biocompatible hydrogel adhesives
Journal of Applied Polymer Science,
Год журнала:
2024,
Номер
141(39)
Опубликована: Июль 22, 2024
Abstract
Hydrogels
can
form
physically
or
chemically
interactions
with
tissues
and
are
widely
used
in
the
design
of
bioadhesive
material.
Polydopamine
(PDA)/polyacrylamide
(PAM)‐based
adhesion
hydrogels
have
emerged
as
one
hydrogel
adhesive
materials
great
potential
for
development.
However,
this
type
has
low
mechanical
properties,
which
certain
limitations
practical
applications.
Herein,
inspired
by
mussel
mechanism,
we
introduced
PDA
into
PAM/3‐aminophenylboronic
acid
grafted
sodium
alginate
(SA‐PBA)
double
network
system
prepared
a
series
hydrogels,
was
crosslinked
dynamic
boronic
ester
bonds
SA‐PBA.
The
experimental
results
established
that
favorable
adhesive,
anti‐fatigue,
stretchable,
self‐healing
properties.
Cytocompatibility
assay
vitro
hemolysis
also
indicated
multifunctional
excellent
cytocompatibility
hemocompatibility.
Язык: Английский