Novel modified probiotic gold nanoparticles loaded with ginsenoside CK exerts an anti-inflammation effect via NF-κB/MAPK signaling pathways

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(4), С. 105650 - 105650

Опубликована: Янв. 24, 2024

Gold nanoparticles (AuNPs) exhibit promising potential as medical materials due to their high biocompatibility, tunable size and shape, excellent drug delivery capabilities, among other unique physicochemical properties. Previous studies have indicated the remarkable anti-inflammatory activity of ginsenoside compound K (CK). However, relatively low bioavailability CK restricts its effective action within biological system. Hence, exploring novel methods based on gold emerges a strategy overcome these challenges in application, thereby enhancing therapeutic effectiveness CK. Probiotic-mediated AuNPs were synthesized using salt lysates Bifidobacterium animalis subsp. lactis. Then, was loaded with form (Bifi-CKAuNPs). The Bifi-CKAuNPs evaluated vitro RAW 264.7 cells vivo mice. NF-κB/ mitogen-activated protein kinases (MAPK) pathway investigated mechanism action. In experiments showed that inhibited activation reactive oxygen species reduced expression iNOS, COX-2, pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) cells. significantly inflammation lung, kidney, liver tissues mice without toxicity. mediated through inhibition NF-κB/MAPK signal transduction, which is well-known critical pathogenesis inflammation. We successfully characterized Bifi-AuNPs, demonstrating potent both vivo. Our results might play key role Bifi-CKAuNPs. These findings underscored significant platform for therapy. observed efficacy cellular animal models, along insights into underlying molecular pathways, positions valuable candidate advancing strategies realm management.

Язык: Английский

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Plasma Assisted Surface Decoration of PLA Nonwoven Materials With Selenium Nanoparticles for Improvement of Antibacterial and Biocompatible Properties

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

ABSTRACT This study aimed to enhance the antibacterial and biocompatible properties of PLA nonwoven materials by plasma‐assisted surface decoration with selenium nanoparticles. were pretreated plasma modification technology for varying durations. Subsequently, Se nanoparticles obtained from redox reaction sodium selenite loaded onto surfaces through impregnation. SEM images demonstrated that pretreatment enhances uniformity as well contents materials. Based on EDS analysis, relative concentration elements increased longer durations, reaching 6.38% after 6 min treatment. XPS analysis confirmed presence elemental Furthermore, results wettability showed Se/PLA composites changed hydrophobic super hydrophilic combined Moreover, bacterial inhibition substantially improved increasing time. The best performance biocompatibility, rates against Staphylococcus aureus Escherichia coli 95.75% 75.54%, respectively, cell viability was over 99% L929 cells. These functionalized exhibit tremendous potential applications in novel

Язык: Английский

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Selenium Nanoparticles for Antioxidant Activity and Selenium Enrichment in Plants

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(11), С. 12881 - 12890

Опубликована: Июнь 5, 2024

Selenium nanoparticles (SeNPs) exhibit great potential across a spectrum of applications, yet the development effective methods for their large-scale preparation remains an emerging field. Herein, we propose method to produce SeNPs using nontoxic bulk selenium powder. By dissolving powder in ethylenediamine (EDA) create homogeneous Se–EDA solution, can be easily formed by adding this solution water. The obtained small and uniform size, fine water dispersibility, low cytotoxicity, also exceptional antioxidant activities. Furthermore, conducted comprehensive examination cultivation selenium-enriched bean sprouts. Our findings indicate that exert minimal effect on growth sprouts while substantially boosting levels seleno-amino acids within them. At SeNP concentration 20 mg/L, increase as much 0.182 μg/g. This study not only provides viable approach producing SeNPs, but opens up opportunity selenium-rich foods meet requirements human health.

Язык: Английский

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Biometabolically Derived Selenium Nanoparticles Armed with Protein Protective Suit toward High‐Performance Li‐Se Batteries

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 16, 2024

Abstract Selenium (Se) serves as a burgeoning high‐energy‐density cathode material in lithium‐ion batteries. However, the development of Se is strictly limited by low utilization and inferior cycling stability arising from intrinsic volume expansion notorious shuttle effect. Herein, microbial metabolism strategy developed to prepare “functional vesicle‐like” globules via Bacillus subtilis subsp . selenite sewage, which nanoparticles are armed with natural biological protein membrane rich nitrogen phosphorus, achieving eco‐efficient conversion trash into treasure (selenite, SeO 3 2− → Selenium, Se). The appealing‐design beneficial accommodate changes electrochemical reactions, confining polyselenides chemisorption, enhancing mechanical strength electrode associated bacteria debris, realizing comprehensive microorganism. By conceptualizing globules, rather than artificial Se‐host composites, for lithium–selenium batteries, it exhibits outstanding improved rate performance. This opens door design smart materials unattainable structure that cannot be achieved traditional approaches, pollutants energy‐storage nanomaterials, will promising research field interdisciplinary energy, biology, environment.

Язык: Английский

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Plant Extracts for Production of Functionalized Selenium Nanoparticles

Materials, Год журнала: 2024, Номер 17(15), С. 3748 - 3748

Опубликована: Июль 29, 2024

In recent years, selenium nanoparticles (SeNPs) have attracted expanding consideration, particularly in the nanotechnology field. This element participates important biological processes, such as antioxidant defense, immune function, and thyroid hormone regulation, protecting cells from oxidative damage. Selenium form of nanoscale particles has drawn attention for its biocompatibility, bioavailability, low toxicity; thus, it found several biomedical applications diagnosis, treatment, monitoring. Green methods SeNP synthesis using plant extracts are considered to be single-step, inexpensive, eco-friendly processes. Besides acting natural reductants, compounds can also serve capping agents, stabilizing size contributing enhanced properties SeNPs. brief overview presents developments this area, focusing on conditions characteristics obtained

Язык: Английский

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In Situ Generation of Poly(3,4‐ethylenedioxythiophene)/Ag₂SeO₃ Nanohybrids at Hexane/Water Interface for Photodegradation of Organic Dyes

Macromolecular Materials and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract Liquid/liquid interfacial synthesis offers a more energy‐efficient alternative to traditional solid‐state reactions, primarily due its adaptability low‐temperature and pressure conditions. In the present work, this innovative approach is explored generate silver selenites within conducting polymer matrix in an situ manner. Therefore, hexane/water interface employed for of Ag 2 SeO 3 on PEDOT support under ambient temperature Furthermore, influence con. H SO 4 polymerization 3,4 – ethylenedioxythiophene regeneration during strategically investigated by ranging compositions precursors. The X‐ray diffraction patterns proved highly crystalline nature nanohybrids with intense peaks attributed attached PEDOT. successful formation PEDOT/Ag also confirmed through Raman spectroscopy, FT‐IR, photoelectron spectroscopic techniques. Additionally, SEM images elemental composition studies verified morphology uniform distribution nanoparticles matrix. efficiency liquid/liquid tuning optical properties, including band gap using UV–vis absorbance photoluminescence characterizations. optimized nanohybrid demonstrated enhanced photocatalytic activity degradation rhodamine B (RhB) methylene Blue (MB), indicating their potential real‐life applications.

Язык: Английский

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Synthesis and Characterization of Se4+@TiO2/PET Composite Photocatalysts with Enhanced Photocatalytic Activity by Simulated Solar Irradiation and Antibacterial Properties

Molecules, Год журнала: 2025, Номер 30(6), С. 1306 - 1306

Опубликована: Март 14, 2025

To fabricate recyclable catalytic materials with high activity, Se4+@TiO2 photocatalytic were synthesized by the sol–gel method. By introducing free radicals on surface of polyester (PET) fabrics through plasma technology, Se4+@TiO2/PET composite activity prepared. The morphology, crystal structure, chemical composition, and performance characterized scanning electron microscopy (SEM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS), ultraviolet–visible absorption (UV–Vis), photoluminescence (PL), respectively. degradation was determined assessing azo dye methyl orange under simulated solar irradiation. results demonstrated that exhibited a superior rate orange, reaching up to 81% sunlight. PL spectra indicated electron–hole pair separation higher than TiO2/PET. Furthermore, UV–Vis relative forbidden band gap be 2.9 eV. narrower, threshold shifted toward visible region, indicating possible increase in its In addition, antibacterial properties subsequently investigated, achieving 99.99% 98.47% inhibition against S. aureus E. coli,

Язык: Английский

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Synthesis, characterizations, properties, modifications and applications of zero-dimensional monoelemental selenium nanomaterials

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216626 - 216626

Опубликована: Март 22, 2025

Язык: Английский

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Synthesis, characterization, and bioactivity of selenium nanoparticles stabilized by regenerated chitin nanofibers

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142791 - 142791

Опубликована: Апрель 1, 2025

Язык: Английский

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Selenium‐Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti‐Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36

Advanced Healthcare Materials, Год журнала: 2025, Номер 14(13)

Опубликована: Апрель 15, 2025

Abstract Wounds repairing after skin damage or diabetes remain a vast medical challenge, which often faces infection, inflammation, oxidative stress, and scarring. Herein, multifunctional selenium‐albumin nanoaccelerator hydrogel (H‐Se NPs‐Gel) is constructed based on the self‐assembly of human serum albumin (HSA) with selenium nanoparticles (Se NPs) using carbomer as carrier, it has remarkable antibacterial, anti‐inflammatory, antioxidant inhibits scarring properties than Se NPs for wound healing. Compared NPs, H‐Se exhibit smaller particle sizes, exceptional stability, better antibacterial activity against common bacteria MRSA, superior anti‐inflammatory capabilities in vitro without toxicity cells. Importantly, exhibits efficacy to NPs‐Gel accelerating healing full‐thickness defects diabetic wounds mice. Interestingly, hypertrophic scar (HTS) model, more effective inhibiting collagen formation suppress scarring, mediated by inhibition CD36. The antagonistic effect CD36 also proved overexpression model. Furthermore, demonstrates excellent safety mice systemic toxicity. an safe therapy strategy promoting reducing clinic.

Язык: Английский

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