Detection of Vkorc1 single nucleotide polymorphisms indicates the presence of anticoagulant rodenticide resistance in Australia's introduced rats† DOI Creative Commons
Alicia F Gorbould, Quinton Burnham, Michael T. Lohr

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Abstract BACKGROUND Anticoagulant rodenticides (ARs) are used globally to manage pest rodent populations. However, resistance ARs in target populations challenges control efforts and can increase risks nontarget species. Resistance is frequently associated with nonsynonymous single nucleotide polymorphisms (nsSNPs) the Vkorc1 gene, this study carried out first survey of introduced rats on Australian mainland. RESULTS We identified three species rat using cytochrome b gene across Brisbane, Melbourne, Perth Sydney: Rattus rattus (Linnaeus 1758) (Lineage I); norvegicus (Berkenhout 1769); tanezumi (Temminck 1844) II). Three nsSNPs were detected gene: Tyr25Phe , Trp59Arg Phe55Ile . The mutation which ARs, was 58 108 R. (53.7%) one 31 (3.2%). It has been suggested that (detected two ) susceptibility haemorrhage, whereas (identified only not reported previously. No CONCLUSION This update status mainland since 1970s employ genetic screening. widespread occurrence urbanized areas Australia suggests potential common practical conferred by needs further investigation as does role hybridization transfer from nuclear genome. © 2025 Author(s). Pest Management Science published John Wiley & Sons Ltd behalf Society Chemical Industry.

Язык: Английский

Detection of Vkorc1 single nucleotide polymorphisms indicates the presence of anticoagulant rodenticide resistance in Australia's introduced rats† DOI Creative Commons
Alicia F Gorbould, Quinton Burnham, Michael T. Lohr

и другие.

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Abstract BACKGROUND Anticoagulant rodenticides (ARs) are used globally to manage pest rodent populations. However, resistance ARs in target populations challenges control efforts and can increase risks nontarget species. Resistance is frequently associated with nonsynonymous single nucleotide polymorphisms (nsSNPs) the Vkorc1 gene, this study carried out first survey of introduced rats on Australian mainland. RESULTS We identified three species rat using cytochrome b gene across Brisbane, Melbourne, Perth Sydney: Rattus rattus (Linnaeus 1758) (Lineage I); norvegicus (Berkenhout 1769); tanezumi (Temminck 1844) II). Three nsSNPs were detected gene: Tyr25Phe , Trp59Arg Phe55Ile . The mutation which ARs, was 58 108 R. (53.7%) one 31 (3.2%). It has been suggested that (detected two ) susceptibility haemorrhage, whereas (identified only not reported previously. No CONCLUSION This update status mainland since 1970s employ genetic screening. widespread occurrence urbanized areas Australia suggests potential common practical conferred by needs further investigation as does role hybridization transfer from nuclear genome. © 2025 Author(s). Pest Management Science published John Wiley & Sons Ltd behalf Society Chemical Industry.

Язык: Английский

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