Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Март 5, 2025
The
successful
approval
of
peptide-based
drugs
can
be
attributed
to
a
collaborative
effort
across
multiple
disciplines.
integration
novel
drug
design
and
synthesis
techniques,
display
library
technology,
delivery
systems,
bioengineering
advancements,
artificial
intelligence
have
significantly
expedited
the
development
groundbreaking
drugs,
effectively
addressing
obstacles
associated
with
their
character,
such
as
rapid
clearance
degradation,
necessitating
subcutaneous
injection
leading
increasing
patient
discomfort,
ultimately
advancing
translational
research
efforts.
Peptides
are
presently
employed
in
management
diagnosis
diverse
array
medical
conditions,
diabetes
mellitus,
weight
loss,
oncology,
rare
diseases,
additionally
garnering
interest
facilitating
targeted
platforms
advancement
vaccines.
This
paper
provides
an
overview
present
market
clinical
trial
progress
therapeutics,
platforms,
It
examines
key
areas
through
literature
analysis
emphasizes
structural
modification
principles
well
recent
advancements
screening,
design,
technologies.
accelerated
including
peptide-drug
complexes,
new
vaccines,
innovative
diagnostic
reagents,
has
potential
promote
era
precise
customization
disease
therapeutic
schedule.
Язык: Английский
Tumor-Homing Peptides as Crucial Component of Magnetic-Based Delivery Systems: Recent Developments and Pharmacoeconomical Perspective
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6219 - 6219
Опубликована: Июнь 5, 2024
According
to
data
from
the
World
Health
Organization
(WHO),
cancer
is
considered
be
one
of
leading
causes
death
worldwide,
and
new
therapeutic
approaches,
especially
improved
novel
treatment
regimens,
are
in
high
demand.
Considering
that
many
chemotherapeutic
drugs
tend
have
poor
pharmacokinetic
profiles,
including
rapid
clearance
limited
on-site
accumulation,
a
combined
approach
with
tumor-homing
peptide
(THP)-functionalized
magnetic
nanoparticles
could
lead
remarkable
improvements.
This
confirmed
by
an
increasing
number
papers
this
field,
showing
on-target
functionalization
improves
their
penetration
properties
ensures
tumor-specific
binding,
which
results
increased
clinical
response.
review
aims
highlight
potential
applications
THPs
combination
carriers
across
various
fields,
pharmacoeconomic
perspective.
Язык: Английский
Innovative design concepts in tumor-targeting peptide-drug conjugates: Insights into emerging applications
Chinese Medical Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Peptide-drug
conjugates
(PDCs)
have
emerged
as
a
promising
strategy
in
cancer
therapy,
offering
improved
therapeutic
efficacy
and
reduced
toxicity.
Compared
to
antibody-drug
(ADCs)
small
molecule-drug
(SMDCs),
PDCs
possess
distinct
advantages,
such
lower
immunogenicity,
tumor
penetration,
simpler
synthesis.
This
review
discusses
the
latest
advancements
PDC
design,
including
novel
peptide
targeting
mechanisms,
linker
selection,
formulation
improvements
for
increased
stability.
Additionally,
it
explores
expanding
clinical
applications
of
examines
their
limitations.
The
aim
this
is
provide
comprehensive
overview
current
progress
outline
future
directions
role
treatment.
Язык: Английский
Unlocking the Potential: Receptor-Mediated Targeted Drug Delivery in Cancer Therapy
Pathology - Research and Practice,
Год журнала:
2025,
Номер
unknown, С. 155955 - 155955
Опубликована: Апрель 1, 2025
Язык: Английский
Development of a blue innovative antioxidant, biodegradable packaging material with Clitoria ternatea L. flos
Food Bioscience,
Год журнала:
2024,
Номер
62, С. 105047 - 105047
Опубликована: Сен. 3, 2024
Today,
the
packaging
industry,
and
in
particular
plastic
are
going
to
experience
a
number
of
challenges
as
result
provisions
included
directive
on
reducing
environmental
impact
materials.
Therefore,
much
attention
is
being
paid
bio-based
based
natural
biodegradable
polymers.
Focus
placed
additives
with
antioxidant
properties
materials,
eliminating
risks
associated
migration
chemical,
often
harmful
substances
into
food.
present
study,
we
obtained
blue
material
flowers
Clitoria
ternatea
L.,
which
additionally
safe
against
selected
plants
invertebrates.
Furthermore,
observed
that
addition
matcha
improved
barrier
tested
films.
Samples
CM
(cellulose/matcha)
CZM
(cellulose/gelatin/matcha)
showed
WVTR
values
14.44
[g/m2ˑd]
9.34
[g/m2ˑd],
respectively.
Antioxidant
activity
testing
by
both
DPPH
radical
FRAP
methods
film
containing
extract.
The
extract
alone
had
highest
(DPPH
IC50
=
1.44
mg/ml;
IT0.5
0.64
mg/ml).
stronger
than
film.
samples
without
were
characterised
TS
13.54
[MPa]
22.24
[MPa],
In
contrast,
their
elongation
at
break
was
74.87
[%]
41.04
[%].
weakest
mechanical
properties:
CZM.
cellulose/matcha
(CM)
EAB
5.11
5.05
[%],
Whereas
cellulose/gelatin/matcha
(CZM)
6.45
1.54
Application
high
concentration
resulted
separation
phase
leading
weakening
change
optical
performance
matcha-containing
films
this
study
due
colour
matcha,
an
effect
presence
dried
flowers.
has
marketing
role
it
can
make
product
'stand
out'
shop
shelf.
Язык: Английский
Method for Screening Sodium Cyanoborohydride for Free Cyanide Content and Its Impact on Bioconjugation Chemistry
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Sodium
cyanoborohydride
(CBH)
is
commonly
used
as
a
mild
reducing
agent
in
the
reductive
amination
of
aldehydes
and
free
amines.
Within
pharmaceutical
industry,
this
reaction
employed
bioconjugation
proteins
peptides.
Free
cyanide
species
such
HCN
NaCN
are
known
residual
impurities
CBH
that
can
contribute
to
formation
undesired
side
products
including
cyanoamines
cyanohydrins.
In
commercial
processes,
potential
for
bound
cyanated
requires
an
analytical
control
strategy
monitor
mitigate
any
risk
human
health.
Given
these
concerns,
minimization
utmost
priority
be
achieved
through
robust
quantitative
screening
starting
materials
cyanide.
Alternative
mitigation
strategies
purification
containing
pure
less
effective
due
minor
chemical
differences
between
expected
product
species.
Herein,
we
present
simple
chromatographic
assay
quantitation
raw
material
sodium
cyanoborohydride.
Method
development,
robustness
evaluation,
scientific
soundness
assessment
reported
with
excellent
linearity,
accuracy,
precision,
specificity.
Additionally,
method
was
applied
evaluation
supplied
from
10
sources,
none
which
report
specification
within
their
certificate
analysis.
The
measured
vendors
ranged
8
80
mM
concentration,
thereby
confirming
value
materials.
Finally,
demonstrate
impact
on
model
ornithine
glyceraldehyde.
Язык: Английский