Recent advances in de novo designed metallopeptides as tailored enzyme mimics
Current Opinion in Chemical Biology,
Год журнала:
2025,
Номер
86, С. 102586 - 102586
Опубликована: Март 21, 2025
Язык: Английский
Electrocatalytic CO2 reduction by a cobalt porphyrin mini-enzyme
Chemical Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Cobalt-mimochrome
VI*a
(CoMC6*a),
a
synthetic
mini-enzyme
with
cobalt
porphyrin
active
site,
is
developed
as
biomolecular
catalyst
for
electrocatalytic
CO2
reduction
in
water.
The
catalytic
turnover
number
reaches
∼14
000
CO
production
selectivity
of
86
:
5
over
H2
under
the
same
conditions.
Varying
applied
potential
and
pK
proton
donor
was
used
to
gain
insight
into
basis
selectivity.
protected
site
CoMC6*a
proposed
enhance
conditions
that
typically
favor
by
related
catalysts.
activity
change
only
marginally
air,
indicating
excellent
oxygen
tolerance.
Язык: Английский
Cu-Albumin Artificial Enzymes with Peroxidase and Oxidase Activity for Stereoselective Oxidations
ACS Catalysis,
Год журнала:
2024,
Номер
14(21), С. 16344 - 16352
Опубликована: Окт. 22, 2024
We
herein
report
a
design
of
artificial
enzymes
by
incorporating
synthetic
copper
complex
into
noncatalytic
bovine
serum
albumin
(Cu-BSA)
to
carry
out
stereoselective
oxidation.
This
Cu-BSA
catalyst
with
stably
bound
Cu
as
cofactor
shows
peroxidase-like
activity
catalyze
epoxidation
styrene
high
chiral
selectivity
(>99%)
R-styrene
epoxide.
With
the
electrochemical
conversion
Cu2+
Cu+,
also
exhibits
oxidase-like
selectively
reduce
oxygen
hydrogen
peroxide
(H2O2),
which
can
be
combined
its
peroxidase
function
drive
oxidation
C═C
bonds
using
air.
enzymatic
system
holds
promise
for
chiral-selective
transformations
non-natural
substances
and
highlights
versatility
proteins
in
enzymes.
Язык: Английский
Hybrid Metal Catalysts as Valuable Tools in Organic Synthesis: An Overview of the Recent Advances in Asymmetric C─C Bond Formation Reactions
Molecules,
Год журнала:
2024,
Номер
29(21), С. 5090 - 5090
Опубликована: Окт. 28, 2024
Carbon–carbon
bond
formation
represents
a
key
reaction
in
organic
synthesis,
resulting
paramount
importance
for
constructing
the
carbon
backbone
of
molecules.
However,
traditional
metal-based
catalysis,
despite
its
advantages,
often
struggles
with
issues
related
to
efficiency,
selectivity,
and
sustainability.
On
other
hand,
while
biocatalysis
offers
superior
selectivity
due
an
extraordinary
recognition
process
substrate,
scope
applicable
reactions
remains
somewhat
limited.
In
this
context,
Artificial
Metalloenzymes
(ArMs)
Metallo
Peptides
(MPs)
offer
promising
not
fully
explored
solution,
merging
two
fields
transition
metal
catalysis
biotransformations,
by
inserting
catalytically
active
cofactor
into
customizable
protein
scaffold
or
coordinating
ion
directly
short
tunable
amino
acid
(Aa)
sequence,
respectively.
As
result,
these
hybrid
catalysts
have
gained
attention
as
valuable
tools
challenging
catalytic
transformations,
providing
systems
new-to-nature
properties
synthesis.
This
review
overview
recent
advances
development
ArMs
MPs,
focusing
on
their
application
asymmetric
carbon–carbon
bond-forming
reactions,
such
carbene
insertion,
Michael
additions,
Friedel–Crafts
cross-coupling
cyclopropanation,
underscoring
versatility
synthesizing
biologically
relevant
compounds.
Язык: Английский
Structure Determination of Zinc and Cadmium Dication Complexes with Intact and Deprotonated Histidyl Glycine and Glycyl Histidine Dipeptides
The Journal of Physical Chemistry B,
Год журнала:
2024,
Номер
128(45), С. 11134 - 11143
Опубликована: Ноя. 1, 2024
Metalated
intact
and
deprotonated
histidyl
glycine
glycyl
histidine
dipeptides
were
investigated
in
the
gas
phase
by
using
infrared
multiple
photon
dissociation
(IRMPD)
spectroscopy
with
light
from
a
free-electron
laser
(FEL).
The
M2+(GlyHis),
M2+(HisGly),
[M(GlyHis-H)]+,
[M(HisGly-H)]+,
where
M
=
Zn
Cd,
probed
to
elucidate
how
His
position
along
peptide
chain
ligand
charge
state
might
influence
structures
observed
phase.
Simulated
annealing
calculations
performed
determine
energetically
low-lying
conformers
isomers
of
these
structures.
Quantum
chemical
used
optimize
at
B3LYP
level
theory
6-311+G(d,p)
def2-TZVP
basis
sets
for
zinc
cadmium
complexes,
respectively.
IRMPD
calculated
linear
absorption
spectra
compared
evaluate
which
are
present.
Relative
energies
various
species
evaluated
single-point
energy
B3LYP,
B3LYP-GD3BJ,
ωB97XD,
MP2(full)
levels
6-311+G(2d,2p)
def2-TZVPP
sets.
For
all
species,
both
metals
mirror
each
other,
those
that
reproduce
experimental
spectrum
determined
be
iminol
ligands
or
iminol-like
ligands.
Additionally,
when
dipeptides,
change
is
correlated
group
deprotonated.
Язык: Английский