Polyphenols: A concise overview on the chemistry, occurrence, and human health

Phytotherapy Research, Год журнала: 2019, Номер 33(9), С. 2221 - 2243

Опубликована: Июль 29, 2019

This review gives an updated picture of each class phenolic compounds and their properties. The most common classification implies the subdivision phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, isoflavones) non‐flavonoids acids, xanthones, stilbens, lignans, tannins) polyphenols. great interest polyphenols is associated with high potential application for food preservation therapeutic beneficial use. relationship between polyphenol intake human health has been exploited special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, cancer. use current existing databases bioactive including described as key tools research.

Язык: Английский

---

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Critical Reviews in Food Science and Nutrition, Год журнала: 2019, Номер 60(6), С. 887 - 939

Опубликована: Янв. 11, 2019

Curcumin is a naturally occurring polyphenolic compound present in rhizome of Curcuma longa belonging to the family zingiberaceae. Growing experimental evidence revealed that curcumin exhibit multitarget biological implications signifying its crucial role health and disease. The current review highlights recent progress mechanisms underlying wide range pharmacological effects against numerous diseases like neuronal, cardiovascular, metabolic, kidney, endocrine, skin, respiratory, infectious, gastrointestinal cancer. ability modulate functions multiple signal transductions are linked with attenuation acute chronic diseases. Numerous preclinical clinical studies have modulates several molecules cell transduction pathway including PI3K, Akt, mTOR, ERK5, AP-1, TGF-β, Wnt, β-catenin, Shh, PAK1, Rac1, STAT3, PPARγ, EBPα, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 MyD-88. has potential prevent and/or manage various due anti-inflammatory, anti-oxidant anti-apoptotic properties an excellent safety profile. In contrast, anti-cancer reflected induction growth arrest apoptosis premalignant malignant cells. This also carefully emphasized pharmacokinetics interaction other drugs. Clinical shown safe at doses 12 g/day but exhibits poor systemic bioavailability. use adjuvant piperine, liposomal curcumin, nanoparticles phospholipid complex enhanced bioavailability therapeutic potential. Further warranted prove ailments.

Язык: Английский

---

Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment

Nutrients, Год журнала: 2019, Номер 11(8), С. 1837 - 1837

Опубликована: Авг. 8, 2019

Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. The multifactorial nature pathology makes patient management, which includes lifelong drug therapy and lifestyle modification, extremely challenging. It well known T2DM a preventable disease, therefore lowering incidence new cases could be key strategy to reduce global impact diabetes. Currently, there growing evidence on efficacy use medicinal plants supplements for prevention management. Among these plants, curcumin gaining interest in scientific community. Curcumin bioactive molecule present rhizome Curcuma longa plant, also as turmeric. different pharmacological biological effects have been described by both vitro vivo studies, include antioxidant, cardio-protective, anti-inflammatory, anti-microbial, nephro-protective, anti-neoplastic, hepato-protective, immunomodulatory, hypoglycaemic anti-rheumatic effects. In animal models, extract delays development, improves β-cell functions, prevents death, decreases insulin resistance. review focuses pre-clinical clinical trials supplementation discusses peculiar mechanisms might ameliorate

Язык: Английский

---

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Март 25, 2022

Linn. (

Язык: Английский

---

Curcumin: Biological Activities and Modern Pharmaceutical Forms

Antibiotics, Год журнала: 2022, Номер 11(2), С. 135 - 135

Опубликована: Янв. 20, 2022

Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and vivo through various mechanisms of action. Numerous studies have identified characterised the pharmacokinetic, pharmacodynamic, clinical properties curcumin. has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, it used as wound-healing agent. However, poor curcumin absorption small intestine, fast metabolism, systemic elimination cause bioavailability human beings. In order to overcome these problems, number formulations been developed. The aim this paper provide overview recent research biological pharmaceutical aspects curcumin, methods sample preparation for its isolation (Soxhlet extraction, ultrasound pressurised fluid microwave enzyme-assisted aided extraction), analytical (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) identification quantification different matrices, techniques developing formulations. optimal use appropriate method will significantly improve evaluation activity

Язык: Английский

---

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(7), С. 2364 - 2364

Опубликована: Март 29, 2020

Curcumin diffuses through cell membranes into the endoplasmic reticulum, mitochondria, and nucleus, where it exerts actions, as an antioxidant property. Therefore, its use has been advocated for chemopreventive, antimetastatic, anti-angiogenic purposes. We conducted a literature review to summarize studies investigating relationship between curcumin colorectal cancer (CRC). In vitro studies, performed on human colon lines, showed that inhibited cellular growth cycle arrest at G2/M G1 phases, well stimulated apoptosis by interacting with multiple molecular targets. vivo have in inflammatory genetic CRC animal models chemopreventive effect. To improve bioavailability, associated small particles increase absorption when orally administered excellent results both inflammation carcinogenesis. used, moreover, component of dietetic formulations chemoprevention. These combinations anticarcinogenetic properties inflammation-related CRC. A synergic effect was suggested using individual constituent dosage, which lower than experimentally used “in vivo” single components. conclusion, falls within category plant origin substances able prevent animals. This property offers promising expectations humans.

Язык: Английский

---

Potential of Curcumin in Skin Disorders

Nutrients, Год журнала: 2019, Номер 11(9), С. 2169 - 2169

Опубликована: Сен. 10, 2019

Curcumin is a compound isolated from turmeric, plant known for its medicinal use. Recently, there growing interest in the medical community identifying novel, low-cost, safe molecules that may be used treatment of inflammatory and neoplastic diseases. An increasing amount evidence suggests curcumin represent an effective agent several skin conditions. We examined most relevant vitro vivo studies published to date regarding use inflammatory, neoplastic, infectious diseases, providing information on bioavailability safety profile. Moreover, we performed computational analysis about curcumin's interaction towards major enzymatic targets identified literature. Our results suggest well-tolerated, However, bypass limitations (low oral bioavailability, metabolism) essential order conduct larger clinical trials could confirm these observations. The possible combination with traditional drugs formulations novel delivery systems very promising field future applicative research.

Язык: Английский

---

Therapeutic potential of curcumin in diabetic complications

Pharmacological Research, Год журнала: 2018, Номер 136, С. 181 - 193

Опубликована: Сен. 13, 2018

Язык: Английский

---

Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies

Phytotherapy Research, Год журнала: 2020, Номер 35(2), С. 864 - 876

Опубликована: Сен. 27, 2020

Recently, the novel life-threatening coronavirus infection (COVID-19) was reported at end of 2019 in Wuhan, China, and spread throughout world little time. The effective antiviral activities natural products have been proved different studies. In this review, regarding herbal treatments on other infections, promising for COVID-19 treatment are suggested. An extensive search Google Scholar, Science Direct, PubMed, ISI, Scopus done with words include coronavirus, COVID-19, SARS, MERS, product, herb, plant, extract. consumption medicine such as Allium sativum, Camellia sinensis, Zingiber officinale, Nigella sativa, Echinacea spp. Hypericum perforatum, Glycyrrhiza glabra, Scutellaria baicalensis can improve immune response. It seems that types terpenoids effects viral replication inhibition could be introduced future Additionally, some alkaloid structures homoharringtonine, lycorine, emetine strong anti-coronavirus effects. Natural inhibit targets S protein (emodin, baicalin) enzymes 3CLpro (Iguesterin), PLpro (Cryptotanshinone), helicase (Silvestrol), RdRp (Sotetsuflavone). Based previous studies, preventive therapeutic agents fight against coronavirus.

Язык: Английский

---

Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 141, С. 111888 - 111888

Опубликована: Июль 5, 2021

Curcumin, isolated from Curcuma longa L., is a fat-soluble natural compound that can be obtained ginger plant tuber roots, which accumulative evidences have demonstrated it resist viral and microbial infection has anti-tumor, reduction of blood lipid glucose, antioxidant removal free radicals, active against numerous disorders various chronic diseases including cardiovascular, pulmonary, neurological autoimmune diseases. In this article highlighted the recent evidence curcuminoids applied in sevral aspects medical problem particular COVID-19 pandemics. We searched several literature databases MEDLINE (PubMed), EMBASE, Web Science, Cochrane Library, Google Scholar, ClinicalTrials.gov website via using curcumin medicinal properties as keyword. All studies published time when database was established to May 2021 retrieved. This review summarizes growing confirmation for mechanisms related curcumin's physiological pharmacological effects with target proteins interaction molecular docking. The purpose provide deeper insight understandings value discovery development new drugs. Curcumin could used prevention or therapy cardiovascular disease, respiratory diseases, cancer, neurodegeneration, infection, inflammation based on cellular biochemical, regulation, suppression immunomodulation.

Язык: Английский

---