Critical Reviews in Oncology/Hematology, Год журнала: 2020, Номер 157, С. 103182 - 103182
Опубликована: Ноя. 24, 2020
Язык: Английский
Life, Год журнала: 2022, Номер 12(9), С. 1427 - 1427
Опубликована: Сен. 13, 2022
In cancer management, drug resistance remains a challenge that reduces the effectiveness of chemotherapy. Several studies have shown curcumin resensitizes cells to chemotherapeutic drugs overcome resistance. present study, we investigate potential therapeutic role in regulating proliferation drug-resistant cancers. Six drug-sensitive (MCF7, HCT116, and A549) -resistant (MCF7/TH, HCT116R, A549/ADR) cell lines were treated with followed by an analysis cytotoxicity, LDH enzyme, total reactive oxygen species, antioxidant enzymes (SOD CAT), fibrosis markers (TGF-β1 protein, fibronectin, hydroxyproline), expression cellular apoptotic (Bcl-2, Bax, Bax/Bcl-2 ratio, Annexin V, cytochrome c, caspase-8). Additionally, SIRT1 was estimated ELISA RT-PCR analysis. Curcumin treatment at doses 2.7-54.3 µM significantly reduced growth sensitive resistant as supported decreased viability increased enzyme compared controls non-treated cells. also 2.7 54.3 regulated fibrogenesis reducing fibrotic Analysis indicated caspase-8, c expression, while Bcl-2 expressions reduced. curcumin-treated μM, non-significant change ROS significant increase SOD CAT activity observed, whereas reduction respective seen higher concentrations along upregulation SIRT1. conclusion, study shows induces anticancer against concentration- time-dependent manner. The protective activities are mediated modulating oxidative stress, fibrosis, activation, inducing apoptosis. Therefore, could be tested auxiliary agent improve prognosis patients
Язык: Английский
Процитировано
31
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114955 - 114955
Опубликована: Июнь 1, 2023
Bioactive natural products (BNPs) are the marrow of medicinal plants, which secondary metabolites organisms and have been most famous drug discovery database. for their enormous number great safety in medical applications. However, BNPs troubled by poor druggability compared with synthesis drugs challenged as medicine (only a few applied clinical settings). In order to find reasonable solution improving BNPs, this review summarizes bioactive nature based on pharmacological research tries explain reasons BNPs. And then focused boosting loaded delivery systems, further concludes advantages systems improvement from perspective nature, discusses why need predicts next direction.
Язык: Английский
Процитировано
20
Laboratory Investigation, Год журнала: 2021, Номер 101(10), С. 1308 - 1317
Опубликована: Июль 19, 2021
Язык: Английский
Процитировано
37
Antioxidants, Год журнала: 2022, Номер 12(1), С. 63 - 63
Опубликована: Дек. 28, 2022
The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug resistance (MDR) mechanisms numerous cancer cell lines. In the present study, inhibition potency two curcuminoids and eleven monocarbonyl curcumin analogues against hGSTP1-1 was investigated. Demethoxycurcumin (Curcumin II) three exhibited highest inhibitory activity towards with IC50 values ranging between 5.45 ± 1.08 37.72 1.02 μM. Kinetic studies most potent inhibitors demonstrated that they function as non-competitive/mixed-type inhibitors. These compounds were also evaluated for their toxicity prostate cells DU-145. Interestingly, strongest inhibitor, (DM96), cytotoxicity an 8.60 1.07 μΜ, while rest ranged 44.59-48.52 μΜ. Structural analysis employing molecular docking, dynamics (MD) simulations, binding-free-energy calculations performed to study four According obtained computational results, DM96 lowest binding free energy, which agreement experimental data. All studied found form hydrophobic interactions residue Gln52, well hydrogen bonds nearby residues Gln65 Asn67. Additional Phe9 Val36 π-π stacking interaction contributed superior DM96. van der Waals component through shape complementarity play important role DM96-inhibitory activity. Overall, our results revealed derivative acts a strong exerts high cytotoxicity, may, therefore, be exploited suppression chemosensitization cells. This provides new insights into development safe effective GST-targeted chemosensitizers.
Язык: Английский
Процитировано
23
Life Sciences, Год журнала: 2023, Номер 332, С. 122119 - 122119
Опубликована: Сен. 21, 2023
Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity, including hepatotoxicity, can lead to interruption or discontinuation potentially effective therapy. In recent years, special attention has been paid search complementary therapies mitigate toxicity. Although there is currently a lack specific interventions prevent hepatotoxicity chemotherapy-treated patients, polyphenol compound curcumin emerged as potential strategy overcome this adverse effect. Here we review, firstly, molecular and physiological mechanisms major risk factors hepatotoxicity. We then present an overview how by targeting mechanisms. Hepatotoxicity well-described side effect cytotoxic drugs that limit their clinical application. Inflammation oxidative stress are most common involved Several studies have shown could and/or palliate liver injury, mainly due its anti-inflammatory, antioxidant, antifibrotic hypolipidemic properties. Further investigation using bioavailable formulations warranted demonstrate efficacy hepatoprotective agent patients.
Язык: Английский
Процитировано
15
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
5
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 8603 - 8620
Опубликована: Авг. 1, 2024
Chemotherapeutic drugs have some drawbacks in antineoplastic therapy, mainly containing seriously toxic side effects caused by injection and multi-drug resistance (MDR). Co-delivery with two or more via nanomicelles is a promising strategy to solve these problems. Oral chemotherapy increasingly preferred owing its potential enhance the life quality of patients.
Язык: Английский
Процитировано
5
Carbohydrate Polymers, Год журнала: 2021, Номер 277, С. 118892 - 118892
Опубликована: Ноя. 15, 2021
Язык: Английский
Процитировано
32
Frontiers in Bioscience-Landmark, Год журнала: 2022, Номер 27(9)
Опубликована: Сен. 16, 2022
Cancer progression and metastases are the leading causes of poor outcomes in patients with colon cancer. Colon cancer metastasis is a multigene, multistep, multistage complex process which target genes, microRNAs, epithelial-stromal transformation, tumour stem cells, microenvironment, various cell signalling pathways implicated Although conventional therapies have made significant advances treating colorectal cancer, they failed to improve survival outcomes. Natural compounds may more potential preventing Active natural exert their antitumor effects by inducing differentiation, promoting apoptosis, inhibiting vascular growth, regulating immunity. compounds, combined therapies, can mutant genes cellular pathways, inhibit microenvironment metastasis. The synergism therapeutics has become promising therapy for metastases.
Язык: Английский
Процитировано
20
Journal of Tissue Engineering, Год журнала: 2023, Номер 14
Опубликована: Янв. 1, 2023
Osteosarcoma is the most prevalent bone malignant tumor in children and teenagers. The defect, recurrence, metastasis after surgery severely affect life quality of patients. Clinically, grafts are implanted. Primary bioceramic scaffolds show a monomodal osteogenesis function. With advances three-dimensional printing technology materials science, while maintaining ability, become more patient-specific obtain additional anti-tumor ability with functional agents being loaded. Anti-tumor therapies include photothermal, magnetothermal, old novel chemo-, gas, photodynamic therapy. These strategies kill tumors through mechanisms to treat refractory osteosarcoma due drug resistance, some have shown potential reverse resistance inhibit metastasis. Therefore, multifunctional printed hold excellent promise for treatments. To better understand, we review background osteosarcoma, primary 3D-printed scaffolds, different prospect future.
Язык: Английский
Процитировано
13