Journal of Dental Sciences,
Год журнала:
2023,
Номер
19(1), С. 268 - 275
Опубликована: Апрель 29, 2023
Diabetes
mellitus
(DM)
and
periodontal
disease
are
both
prevalent
chronic
inflammatory
disorders
that
have
significant
health
impact.
Many
studies
pointed
out
advanced
glycation
end-products
(AGEs)
in
DM
induces
inflammaging,
which
is
a
pre-aging
hyperinflammatory
condition,
it
has
been
linked
to
greater
likelihood
developing
periodontitis.
Inflammaging
shown
be
driven
by
AGEs-induced
cell
senescence,
cytokines,
oxidative
stress,
resulting
the
degradation
of
periodontium.
Quercetin
abilities
decrease
inflammation
stress
variety
tissues,
however,
effect
diabetic
periodontitis
remains
uncertain.
Thus,
aim
this
study
was
investigate
its
impacts
on
inflammaging
We
examined
proliferation
human
gingival
fibroblasts
(HGF),
wound
healing,
IL-6
IL-8
secretions,
cellular
senescence
expression,
formation
reactive
oxygen
species
(ROS)
response
AGE
stimulation
with
without
intervention.
Following
that,
we
looked
into
NF-κβ
activity
see
if
mediate
effects
via
pro-inflammatory
signaling.
at
20
μM
below
did
not
any
impact
HGFs'
rate.
intervention
improved
AGEs-impaired
addition
attenuation
ROS
dose-dependent
pattern.
Moreover,
therapy
dose-dependently
inhibited
along
associated
secretion
phenotype
(SASP)
secretions
such
as
IL-8.
Western
blot
analysis
indicated
able
reverse
phosphorylation
p65
Iκβ
AGEs-stimulated
HGFs,
demonstrating
can
modulate
pathway.
Accumulation
AGEs
elicit
seen
increased
expression
stress.
The
results
proposed
ameliorate
improve
healing
suppression
pathway
hence,
may
promising
approach
for
treatment
diabetes-associated
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Quercetin,
a
naturally
non-toxic
flavonoid
within
the
safe
dose
range
with
antioxidant,
anti-apoptotic
and
anti-inflammatory
properties,
plays
an
important
role
in
treatment
of
aging-related
diseases.
Sirtuin
1
(SIRT1),
member
NAD+-dependent
deacetylase
enzyme
family,
is
extensively
explored
as
potential
therapeutic
target
for
attenuating
aging-induced
disorders.
SIRT1
possess
beneficial
effects
against
diseases
such
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
Depression,
Osteoporosis,
Myocardial
ischemia
(M/I)
reperfusion
(MI/R),
Atherosclerosis
(AS),
Diabetes.
Previous
studies
have
reported
that
aging
increases
tissue
susceptibility,
whereas,
regulates
cellular
senescence
multiple
processes,
including
SIRT1/Keap1/Nrf2/HO-1
SIRTI/PI3K/Akt/GSK-3β
mediated
oxidative
stress,
SIRT1/NF-κB
SIRT1/NLRP3
regulated
inflammatory
response,
SIRT1/PGC1α/eIF2α/ATF4/CHOP
SIRT1/PKD1/CREB
controlled
phosphorylation,
SIRT1-PINK1-Parkin
mitochondrial
damage,
SIRT1/FoxO
autophagy,
SIRT1/FoxG1/CREB/BDNF/Trkβ-catenin
neuroprotective
effects.
In
this
review,
we
summarized
improvement
attenuation
effect
quercetin
on
relationship
between
relevant
signaling
pathways
by
SIRT1.
Moreover,
functional
regulation
markers
function,
autophagy
apoptosis
through
was
discussed.
Finally,
prospects
extracellular
vesicles
(EVs)
loading
delivery,
SIRT1-mediated
EVs
signal
carriers
treating
diseases,
well
discussed
ferroptosis
alleviation
to
protect
via
activating
Generally,
may
serve
promising
inhibiting
reducing
responses,
restoring
dysfunction.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 712 - 712
Опубликована: Фев. 20, 2023
Due
to
rising
incidence
rates
of
liver
cancer
and
worries
about
the
toxicity
current
chemotherapeutic
medicines,
hunt
for
further
alternative
methods
treat
this
malignancy
has
escalated.
Compared
chemotherapy,
quercetin,
a
flavonoid,
is
relatively
less
harmful
normal
cells
regarded
as
an
excellent
free-radical
scavenger.
Apoptotic
cell
death
caused
by
quercetin
been
demonstrated
many
prior
studies.
It
present
in
fruits,
vegetables,
herbs.
Quercetin
targets
apoptosis,
upregulating
Bax,
caspase-3,
p21
while
downregulating
Akt,
PLK-1,
cyclin-B1,
cyclin-A,
CDC-2,
CDK-2,
Bcl-2.
Additionally,
it
reported
increase
STAT3
protein
degradation
decreasing
activation.
potential
future
chemoprevention,
based
on
substantial
research
its
anticancer
effects.
The
review
discusses
quercetin’s
mechanisms
action,
nanodelivery
strategies,
other
cellular
effects
cancer.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1000 - 1000
Опубликована: Фев. 25, 2024
Quercetin
is
a
flavonoid
with
low
molecular
weight
that
belongs
to
the
human
diet’s
phenolic
phytochemicals
and
nonenergy
constituents.
has
potent
antioxidant
capacity,
being
able
capture
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
chlorine
(ROC),
which
act
as
reducing
agents
by
chelating
transition-metal
ions.
Its
structure
five
functional
hydroxyl
groups,
work
electron
donors
are
responsible
for
capturing
free
radicals.
In
addition
its
different
pharmacological
properties
of
quercetin
have
been
described,
such
carcinostatic
properties;
antiviral,
antihypertensive,
anti-inflammatory
ability
protect
low-density
lipoprotein
(LDL)
oxidation,
inhibit
angiogenesis;
these
developed
in
this
review.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Янв. 12, 2024
Abstract
This
review
provides
an
update
on
recent
findings
from
basic,
translational,
and
clinical
studies
the
molecular
mechanisms
of
mitochondrial
dysfunction
apoptosis
hepatocytes
in
multiple
liver
diseases,
including
but
not
limited
to
alcohol-associated
disease
(ALD),
metabolic
dysfunction-associated
steatotic
(MASLD),
drug-induced
injury
(DILI).
While
ethanol-inducible
cytochrome
P450-2E1
(CYP2E1)
is
mainly
responsible
for
oxidizing
binge
alcohol
via
microsomal
ethanol
system,
it
also
metabolizing
many
xenobiotics,
pollutants,
chemicals,
drugs,
specific
diets
abundant
n-6
fatty
acids,
into
toxic
metabolites
organs,
liver,
causing
pathological
insults
through
organelles
such
as
mitochondria
endoplasmic
reticula.
Oxidative
imbalances
(oxidative
stress)
promote
covalent
modifications
lipids,
proteins,
nucleic
acids
enzymatic
non-enzymatic
mechanisms.
Excessive
changes
stimulate
various
post-translational
(PTMs)
transcription
factors,
histones.
Increased
PTMs
proteins
inactivate
enzymes
involved
reduction
oxidative
species,
acid
metabolism,
mitophagy
pathways,
leading
dysfunction,
energy
depletion,
apoptosis.
Unique
other
organelles,
control
signaling
cascades
bioenergetics
(fat
metabolism),
inflammation,
apoptosis/necrosis
hepatocytes.
When
homeostasis
shifted,
these
pathways
become
altered
or
shut
down,
likely
contributing
death
with
activation
inflammation
hepatic
stellate
cells,
fibrosis
cirrhosis.
will
encapsulate
how
contributes
hepatocyte
several
types
diseases
order
provide
recommendations
targeted
therapeutics.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 15
Опубликована: Июль 16, 2022
Alcoholic
liver
disease
(ALD)
is
a
multifaceted
process
that
involves
excessive
lipid,
reactive
oxygen
species
(ROS)
production,
unbalanced
mitochondrial
homeostasis,
and
ultimate
cell
death.
Quercetin
dietary
phytochemical
presented
in
various
fruits
vegetables,
which
has
anti-inflammatory
antioxidant
effects.
According
to
recent
advances
pharmanutritional
management,
the
effects
of
quercetin
on
processes
have
attracted
attention.
In
study,
we
explored
whether
could
attenuate
ethanol-induced
hepatocyte
pyroptosis
by
maintaining
homeostasis
studied
its
hepatoprotective
effect
underlying
mechanism.
We
chose
L02
cells
establish
an
vitro
model
with
pyroptosis.
Then,
at
approximately
80%
confluence
were
treated
(80,
40,
20
μM).
The
viability
(CCK-8)
was
used
investigate
proliferation.
Relative
assay
kits
measure
oxidative
stress
index
(
OSI=TOS/TAS
),
lipid
peroxidation
(LPO)
release,
membrane
potential
δΨm
).
morphology
mitochondria
characterized
transmission
electron
microscopy-
(TEM-)
based
analysis.
Mitochondrial
dynamics
(Mito
Tracker
Green),
mitROS
(MitoSOX
Red
Superoxide)
nuclear
DNA
(nDNA)
damage
(γH2AX)
markers
detected
immunofluorescence.
mRNA
levels
function
(including
(mtDNA)
transcription
genes
TWNK,
MTCO1,
MFND)
pyroptosis-related
RT-qPCR,
protein
NLRP3,
ASC,
caspase1,
cleaved-caspase1,
IL-18,
IL-1β,
GSDMD-N
western
blot.
results
showed
treatment
downregulated
redox
status,
droplets,
LPO
restored
damaged
potential,
repaired
mtDNA
damage,
PGC-1α
transfer,
dynamics.
gene
expressions
decreased,
effectively
inhibited
Therefore,
indicated
protected
via
scavenging
promoting
PGC-1α-mediated
cells.
Antioxidants,
Год журнала:
2023,
Номер
12(6), С. 1212 - 1212
Опубликована: Июнь 3, 2023
Reactive
oxygen
species
(ROS)
are
important
second
messengers
in
many
metabolic
processes
and
signaling
pathways.
Disruption
of
the
balance
between
ROS
generation
antioxidant
defenses
results
overproduction
subsequent
oxidative
damage
to
biomolecules
cellular
components
that
disturb
function.
Oxidative
stress
contributes
initiation
progression
liver
pathologies
such
as
ischemia-reperfusion
injury
(LIRI),
non-alcoholic
fatty
disease
(NAFLD),
hepatocellular
carcinoma
(HCC).
Therefore,
controlling
production
is
an
attractive
therapeutic
strategy
relation
their
treatment.
In
recent
years,
increasing
evidence
has
supported
effects
polyphenols
on
via
regulation
levels.
current
review,
we
summarize
polyphenols,
quercetin,
resveratrol,
curcumin,
during
conditions
induce
injury,
LIRI,
NAFLD,
HCC.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(11), С. 4999 - 5016
Опубликована: Июль 25, 2023
Abstract
Numerous
pharmacological
effects
of
quercetin
have
been
illustrated,
including
antiinflammation,
antioxidation,
and
anticancer
properties.
In
recent
years,
the
antioxidant
activity
has
extensively
reported,
in
particular,
its
impacts
on
glutathione,
enzyme
activity,
signaling
transduction
pathways,
reactive
oxygen
species
(ROS).
Quercetin
also
demonstrated
to
exert
a
striking
antiinflammatory
effect
mainly
by
inhibiting
production
cytokines,
reducing
expression
cyclooxygenase
lipoxygenase,
preserving
integrity
mast
cells.
By
regulating
oxidative
stress
inflammation,
which
are
regarded
as
two
critical
processes
involved
defense
regular
physiological
operation
biological
systems,
validated
be
effective
treating
variety
disorders.
Symptoms
these
reactions
linked
degenerative
metabolic
disorders,
syndrome,
cardiovascular,
neurodegeneration,
cancer,
nonalcoholic
fatty
liver
disease.
Despite
that
evidence
demonstrates
antioxidants
employed
prevent
excessive
inflammatory
processes,
there
still
concerns
regarding
expense,
accessibility,
side
agents.
Notably,
natural
products,
especially
those
derived
from
plants,
widely
accessible,
affordable,
generally
safe.
this
review,
abilities
active
ingredient
application
stress‐related
disorders
outlined
detail.
