Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 19, 2025
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 98, С. 105924 - 105924
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
5
Pharmaceuticals, Год журнала: 2024, Номер 17(7), С. 849 - 849
Опубликована: Июнь 28, 2024
The development and course of inflammatory bowel disease (IBD) are significantly influenced by inflammation oxidative stress. Antioxidant therapy is a promising therapeutic option to enhance the clinical results these individuals in this particular scenario. purpose study assess impact curcumin, with or without piperine, on cytokines, fecal calprotectin (CalF), stress enzymatic non-enzymatic indicators patients IBD.
Язык: Английский
Процитировано
5
Biomedical Technology, Год журнала: 2024, Номер 7, С. 32 - 45
Опубликована: Июль 16, 2024
Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through bioactive compounds, which target the multifaceted nature stroke-induced damage. However, clinical application NM is limited by challenges in bioavailability specificity. This review article presents an advanced perspective on integrating nanotechnology with create potent nanodelivery systems for ischemic treatment. We highlight pathological underpinnings stroke, including oxidative stress, inflammation, apoptosis, discuss how compounds offer targeted mitigation strategies. By incorporating platforms, such as liposomes nanoparticles, these -based can achieve enhanced targeting, solubility, controlled release, significantly improving outcomes while reducing side effects. Despite developments, translation nano-enhanced into practice faces obstacles, manufacturing scalability, regulatory approval, safety evaluations. emphasizes potential combining advance therapy, calling integrated research efforts overcome existing barriers fully realize benefits this approach.
Язык: Английский
Процитировано
5
Journal of drug targeting, Год журнала: 2024, Номер 32(10), С. 1207 - 1232
Опубликована: Авг. 6, 2024
Cancer is a leading cause of death worldwide, and imposes substantial socioeconomic burden with little impact especially on aggressive types cancer. Conventional therapies have many serious side effects including generalised systemic toxicity which limits their long-term use. Tumour resistance recurrence another main problem associated conventional therapy. Purified or extracted natural products been investigated as cost-effective cancer chemoprotective agents the potential to reverse delaying carcinogenesis. Curcumin (CUR) polyphenolic component, exhibits pharmacological activities such anti-cancer, anti-inflammatory, anti-microbial, activity against neurodegenerative diseases Alzheimer, antidiabetic (type II diabetes), anticoagulant properties, wound healing in both preclinical clinical studies. Despite these effective protective CUR has several limitations, poor aqueous solubility, low bioavailability, chemical instability, rapid metabolism short half-life time. To overcome pharmaceutical problems free CUR, novel nanomedicine strategies (including polymeric nanoparticles (NPs) poly (lactic-co-glycolic acid) (PLGA) NPs developed. These formulations improve therapeutic efficacy curcuminoids. In this review, we comprehensively summarise discuss recent
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114910 - 114910
Опубликована: Май 22, 2023
Migraine, a neurovascular condition, is chronic and lifelong disease that affects about 15% of the population worldwide. Although exact pathophysiology etiology migraine are still unclear, oxidative stress, inflammation, neuroendocrine imbalances identified as critical risk factors for attacks. Curcumin an active component polyphenolic diketone compound extracted from turmeric. promising candidate preventing controlling due to its anti‑inflammatory, antioxidative, anti-protein aggregate, analgesic effects. In present review, we have evaluated experimental clinical studies investigating impact liposomal curcumin nano-curcumin on frequency severity attacks in patients. results promising, more should be conducted this area show efficacies symptoms investigate potential mechanisms.
Язык: Английский
Процитировано
12
Journal of Functional Foods, Год журнала: 2023, Номер 108, С. 105705 - 105705
Опубликована: Авг. 5, 2023
Hepatocellular carcinoma (HCC), as a common malignancy of the liver, is second leading cause cancer-related death in world and mostly occurs patients with background chronic liver disease. Patents this represent various signs symptoms, such splenomegaly, peripheral edema, jaundice. More than 70 % HCC cases are advanced stage because lacking diagnostic systems indications early stages, therefore giving rise to high lethality rate involved patients. Against malignancy, several therapeutic methods have been recommended, like surgical resection, immunotherapy, transplantation, chemotherapeutic drugs (e.g., doxorubicin, mitomycin C, cisplatin); however, these curative modalities not created serious hope for patents. Nowadays, herbal medicine natural compounds has offered different illnesses, cancer. Among these, some components their nano-based formulations, especially curcumin (a polyphenol extract Curcuma longa), become point interest treating HCC. Hence, review aimed evaluate anticancer effects its biological potential based on current documents.
Язык: Английский
Процитировано
12
Nutrition Journal, Год журнала: 2023, Номер 22(1)
Опубликована: Дек. 11, 2023
Abstract Background Stroke is a leading cause of death worldwide, which associated with heavy economic and social burden. The purpose this study was to investigate the effects supplementation curcumin-piperine combination in patients ischemic stroke rehabilitation stage. Methods In randomized controlled trial, 66 were into two groups receiving tablets (500 mg curcumin + 5 piperine) matched placebo for 12 weeks. High-sensitivity C-reactive protein (hs-CRP), carotid intima-media thickness (CIMT), thrombosis, total antioxidant capacity (TAC), lipid profile, anthropometric indices, blood pressure, quality life assessed before after intervention. Statistical data analysis done using SPSS22 software. Results A 56 mean age 59.80 ± 4.25 years completed trial. Based on ANCOVA test, adjusted baseline values, weeks resulted significant reductions serum levels hs-CRP ( p = 0.026), cholesterol (TC) 0.009), triglycerides (TG) 0.001), CIMT 0.002), weight P waist circumference 0.024), systolic diastolic pressure < increase TAC 0.001) comparison placebo. Pain score significantly increased both groups; however, its higher group compared intervention 0.007). No changes observed between terms fibrinogen, low-density lipoprotein (LDL), high-density (HDL), indices. Conclusion Curcumin-piperine had beneficial CIMT, hs-CRP, TC, TG, TAC,
Язык: Английский
Процитировано
12
European Polymer Journal, Год журнала: 2023, Номер 196, С. 112215 - 112215
Опубликована: Июнь 10, 2023
Язык: Английский
Процитировано
11
Biomedicines, Год журнала: 2024, Номер 12(2), С. 268 - 268
Опубликована: Янв. 24, 2024
Gliomas are aggressive brain tumors with poor prognosis even after surgical removal and radio-chemotherapy, stressing the urgency to find alternative therapies. Several preclinical studies evaluating anticancer effect of curcumin in animal models glioma reported, but a systematic review meta-analysis these studies, considering different experimental conditions used, has not been made up this date. A search databases (Pubmed, Web Science, Scopus, SciELO) following PRISMA statement was conducted during November 2023 systematically identify articles assessing murine xenograft identified 15 articles, which were subdivided into 24 studies. Tumor volume before treatment or vehicle extracted efficacy evaluated by performing random effects data. Publication bias impact on assessed. Treatment decreased tumor volume. Comparing control groups, overall weighted standardized difference means −2.079 (95% CI: −2.816 −1.341; p-value < 0.001). The observed for models, types cells, administration routes, formulations. does invalidate curcumin’s effectiveness. findings suggest potential therapeutic against glioma.
Язык: Английский
Процитировано
4
Cytotechnology, Год журнала: 2025, Номер 77(2)
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0