Food Science & Nutrition,
Год журнала:
2024,
Номер
12(12), С. 9951 - 9973
Опубликована: Ноя. 7, 2024
ABSTRACT
Understanding
the
molecular
signaling
pathways
of
colorectal
cancer
(CRC)
can
be
accepted
as
first
step
in
treatment
strategy.
Permanent
mTOR
activation
stimulates
CRC
process
via
various
biological
processes.
It
supplies
survival
stem
cells,
tumorigenesis,
morbidity,
and
decreased
response
to
drugs
pathogenesis.
Therefore,
inhibition
by
numerous
bioactive
components
may
effective
against
CRC.
The
study
aims
discuss
therapeutic
capacity
polyphenols,
terpenoids,
alkaloids
on
PI3K/Akt/mTOR
pathway.
potential
effects
compounds
pathway's
upstream
downstream
targets
are
examined.
Each
component
causes
physiological
processes,
such
triggering
free
radical
production,
disruption
mitochondrial
membrane
potential,
cell
cycle
arrest,
migration,
suppression
glycolysis
through
inhibition.
As
a
result,
carcinogenesis
is
inhibited
inducing
apoptosis
autophagy.
However,
it
should
noted
that
studies
primarily
vitro
dose‐dependent
researchers.
This
raises
awareness
about
role
phenolic
treating
CRC,
contributing
their
future
use
anticancer
agents.
These
have
developed
into
food
supplementation
prevent
treat
types
including
review
has
lead
further
development
clinical
studies.
In
future,
applying
several
agents
using
advanced
drug
delivery
systems
contribute
with
3D
culture
vivo
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1642 - 1642
Опубликована: Май 27, 2024
Liver
cancer
ranks
third
globally
among
causes
of
cancer-related
deaths,
posing
a
significant
public
health
challenge.
However,
current
treatments
are
inadequate,
prompting
growing
demand
for
novel,
safe,
and
effective
therapies.
Natural
products
(NPs)
have
emerged
as
promising
candidates
in
drug
development
due
to
their
diverse
biological
activities,
low
toxicity,
minimal
side
effects.
This
paper
begins
by
reviewing
existing
treatment
methods
drugs
liver
cancer.
It
then
summarizes
the
therapeutic
effects
NPs
sourced
from
various
origins
on
Finally,
we
analyze
potential
mechanisms
treating
cancer,
including
inhibition
angiogenesis,
migration,
invasion;
regulation
cell
cycle;
induction
apoptosis,
autophagy,
pyroptosis,
ferroptosis;
influence
tumor
metabolism;
immune
regulation;
intestinal
function;
key
signaling
pathways.
systematic
review
aims
provide
comprehensive
overview
research
treatment,
offering
foundation
further
application
pharmaceuticals
functional
foods.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 263 - 263
Опубликована: Фев. 17, 2025
Background:
Thyroid
cancer
(TC)
is
the
most
prevalent
endocrine
malignancy,
and
categorized
into
well-differentiated
aggressive
anaplastic
types.
Novel
therapeutic
modalities
are
needed
for
TC.
Nanomedicine
a
promising
strategy
development
of
precision
medicine.
In
this
context,
we
investigated
use
nanogels
(NGs)
to
deliver
agents
with
different
physicochemical
properties,
specifically
hydrophilic
agent
doxorubicin
(DOX)
hydrophobic
compound
curcumin
(CUR),
in
TC
cell
lines.
Methods:
Nα-9-fluorenylmethoxycarbonyl-diphenylalanine
(Fmoc-FF)
peptide-based
NGs
loaded
DOX
CUR
were
formulated
using
solvent-switch
method.
DOX-loaded
previously
characterized.
CUR-loaded
characterized
through
rheology,
scanning
electron
microscopy
(SEM),
dynamic
light
scattering
(DLS),
nanoparticle
tracking
analysis
(NTA),
Fourier
transform
infrared
(FT-IR)
spectroscopy.
Confocal
microscopy,
q-RT-PCR,
ATP
lite
assays
performed
evaluate
uptake
delivery
DOX-
on
Results:
exhibited
mean
diameter
approximately
204.3
nm
zeta
potential
-34.6
mV,
indicative
good
stability.
vitro
release
studies
revealed
sustained
profile
over
72
h.
Functional
analyses
demonstrated
that
Fmoc-FF-loaded
internalized
They
primarily
localized
cytoplasm
rather
than
early
endosomes,
thereby
ensuring
intracellular
Furthermore,
Fmoc-FF
reduced
nuclear
kinetics
cells,
suggesting
reduction
dose-limiting
toxicity.
Comparative
similar
internalization
delayed
uptake,
highlighting
efficacy
delivering
agents.
Conclusions:
Overall,
data
suggest
represent
diverse
properties
TC,
enhancing
their
safety
warranting
further
investigation.
Theranostics,
Год журнала:
2024,
Номер
14(12), С. 4822 - 4843
Опубликована: Янв. 1, 2024
Cancer-associated
fibroblasts
(CAFs)
are
the
key
components
of
immune
barrier
in
liver
cancer.
Therefore,
gaining
a
deeper
understanding
heterogeneity
and
intercellular
communication
CAFs
holds
utmost
importance
boosting
immunotherapy
effectiveness
improving
clinical
outcomes.
Pharmaceutical Biology,
Год журнала:
2025,
Номер
63(1), С. 53 - 67
Опубликована: Янв. 10, 2025
Context
Melanoma's
aggressiveness
and
resistance
to
radiotherapy
highlight
an
urgent
need
for
innovative
treatments.
Traditional
Chinese
medicine
(TCM)
offers
a
unique
approach
through
its
'four
natures'
theory—cold,
cool,
warm,
hot.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(5), С. 628 - 656
Опубликована: Янв. 29, 2024
In
this
study,
the
pH-responsive
API-CMCS-SA
(ACS)
polymeric
nanoparticles
(NPs)
based
on
1-(3-amino-propyl)
imidazole
(API),
stearic
acid
(SA),
and
carboxymethyl
chitosan
(CMCS)
were
fabricated
for
effective
transport
of
curcumin
(CUR)
in
liver
cancer.
CUR-ACS-NPs
with
various
degrees
substitution
(DS)
employed
to
prepare
through
ultrasonic
dispersion
method.
The
effect
different
DS
NPs
formation
was
discussed.
obtained
(DSSA=12.4%)
had
high
encapsulation
rate
(more
than
85%)
uniform
particle
size
(186.2
±
1.42
nm).
showed
better
stability
other
groups.
Drug
release
from
pH-dependent,
more
90%
or
65%
CUR
released
48
h
weakly
medium
(pH
5.0
6.0,
respectively).
Additionally,
increased
intracellular
accumulation
demonstrated
anticancer
HepG2
cells
compared
prolonged
retention
time
drug,
area
under
curve
(AUC)
significantly
vivo.
vivo
antitumor
study
further
revealed
that
exhibited
capability
inhibiting
tumor
growth
lower
systemic
toxicity.
Meanwhile,
CUR,
CUR-CS-NPs,
could
be
detected
evaluated
organs,
including
tumor,
liver,
spleen,
lung,
heart,
kidney
distribution
studies.
Among
them,
reached
maximum
concentration
at
site,
indicating
tumor-targeting
properties.
short,
results
suggested
act
a
prospective
drug
system
delivery
cancer
treatment.
